The Moskowitz laboratory is devoted to the genetic, genomic and molecular study of gene regulatory networks. A single overarching theme governs work in the Moskowitz laboratory: that understanding essential gene regulatory networks will unveil the molecular logic governing biological processes, and that understanding network disruption will inform the molecular basis underlying disease. We have recently pioneered approaches to identify non-coding RNAs as markers and modulators of enhancer function (Yang and Nadadur et al, 2017). The Moskowitz laboratory has focused on two areas of cardiac biology: (1) cardiac conduction with respect to cardiac arrhythmias and (2) cardiac development with respect to Congenital Heart Disease (CHD). In cardiac development, we investigate the genetic, genomic and developmental landscape of cardiac morphogenesis. We have identified an essential role for Hedgehog signaling in the cardiac development and congenital heart disease and contributed to a paradigm shift in the understanding of cardiac septation (e.g. Hoffmann et al., 2009; Xie et al., 2012; Zhou et al., 2017). We have recently identified a surprising and novel role for Hedgehog signaling in maintaining cardiac progenitor status and preventing premature differentiation (Rowton et al., 2018). In cardiac rhythm, we investigate the molecular mechanisms underlying the genetic basis of cardiac arrhythmias. We have defined the first molecular networks and linking GWAS loci in cardiac conduction (Arnolds et al, 2012), the first molecular network in Atrial Fibrillation, the most common arrhythmia world-wide (Nadadur et al., 2016) and the functional genomic mechanisms underlying genetic associations (Van den Boogaard et al., 2014).
Harvard Medical School
Boston, MA
Fellowship - Genetics
2006
Children's Hospital
Boston, MA
Fellowship - Congenital Heart Disease
2001
Brigham and Women’s Hospital
Boston, MA
Residency - Pathology
2000
University of Wisconsin, School of Medicine
Madison, WI
M.D./Ph.D. - Biochemistry
1998
Marine Biological Laboratory
Woods Hole, MA
- Embryology
1994
Wesleyan University
Middletown, CT
B.A. - Biochemistry/Molecular Biology
1988
A Genomic Link From Heart Failure to Atrial Fibrillation Risk: FOG2 Modulates a TBX5/GATA4-Dependent Atrial Gene Regulatory Network.
A Genomic Link From Heart Failure to Atrial Fibrillation Risk: FOG2 Modulates a TBX5/GATA4-Dependent Atrial Gene Regulatory Network. Circulation. 2024 Apr 09; 149(15):1205-1230.
PMID: 38189150
Tbx5 maintains atrial identity in post-natal cardiomyocytes by regulating an atrial-specific enhancer network.
Tbx5 maintains atrial identity in post-natal cardiomyocytes by regulating an atrial-specific enhancer network. Nat Cardiovasc Res. 2023 Oct; 2(10):881-898.
PMID: 38344303
An Anterior Second Heart Field Enhancer Regulates the Gene Regulatory Network of the Cardiac Outflow Tract.
An Anterior Second Heart Field Enhancer Regulates the Gene Regulatory Network of the Cardiac Outflow Tract. Circulation. 2023 11 21; 148(21):1705-1722.
PMID: 37772400
The cGAS-STING pathway is dispensable in a mouse model of LMNA-cardiomyopathy despite nuclear envelope rupture.
The cGAS-STING pathway is dispensable in a mouse model of LMNA-cardiomyopathy despite nuclear envelope rupture. bioRxiv. 2023 Aug 28.
PMID: 37693381
Single-cell genomics improves the discovery of risk variants and genes of atrial fibrillation.
Single-cell genomics improves the discovery of risk variants and genes of atrial fibrillation. Nat Commun. 2023 08 17; 14(1):4999.
PMID: 37591828
ETV2 primes hematoendothelial gene enhancers prior to hematoendothelial fate commitment.
ETV2 primes hematoendothelial gene enhancers prior to hematoendothelial fate commitment. Cell Rep. 2023 06 27; 42(6):112665.
PMID: 37330911
Tbx5 maintains atrial identity by regulating an atrial enhancer network.
Tbx5 maintains atrial identity by regulating an atrial enhancer network. bioRxiv. 2023 Apr 22.
PMID: 37131696
Frem1 activity is regulated by Sonic hedgehog signaling in the cranial neural crest mesenchyme during midfacial morphogenesis.
Frem1 activity is regulated by Sonic hedgehog signaling in the cranial neural crest mesenchyme during midfacial morphogenesis. Dev Dyn. 2023 04; 252(4):483-494.
PMID: 36495293
Transcriptional Dysregulation Underlies Both Monogenic Arrhythmia Syndrome and Common Modifiers of Cardiac Repolarization.
Transcriptional Dysregulation Underlies Both Monogenic Arrhythmia Syndrome and Common Modifiers of Cardiac Repolarization. Circulation. 2023 03 07; 147(10):824-840.
PMID: 36524479
Hedgehog signaling activates a mammalian heterochronic gene regulatory network controlling differentiation timing across lineages.
Hedgehog signaling activates a mammalian heterochronic gene regulatory network controlling differentiation timing across lineages. Dev Cell. 2022 09 26; 57(18):2181-2203.e9.
PMID: 36108627
Fellow of the American Heart Association
American Heart Association
2015
American Society of Clinical Investigation
American Society of Clinical Investigation
2014
Established Investigator Award
American Heart Association
2013
Louis N. and Arnold M. Katz Basic Research Prize
American Heart Association
2006