My research lab focuses on developing novel computational methods to better understand the complex interactions between immune cells, their environment, and the microbiome. Our goal is to uncover clinically relevant insights and pave the way for new diagnostics and therapies that can improve human health.
Rare variant contribution to the heritability of coronary artery disease.
Rare variant contribution to the heritability of coronary artery disease. Nat Commun. 2024 Oct 09; 15(1):8741.
PMID: 39384761
Evaluating the use of blood pressure polygenic risk scores across race/ethnic background groups.
Evaluating the use of blood pressure polygenic risk scores across race/ethnic background groups. Nat Commun. 2023 06 02; 14(1):3202.
PMID: 37268629
Gut commensal bacteria enhance pathogenesis of a tumorigenic murine retrovirus.
Gut commensal bacteria enhance pathogenesis of a tumorigenic murine retrovirus. Cell Rep. 2022 09 13; 40(11):111341.
PMID: 36103821
Integration of tumor extrinsic and intrinsic features associates with immunotherapy response in non-small cell lung cancer.
Integration of tumor extrinsic and intrinsic features associates with immunotherapy response in non-small cell lung cancer. Nat Commun. 2022 07 13; 13(1):4053.
PMID: 35831288
Privacy preserving validation for multiomic prediction models.
Ahmed T, Carty MA, Wenric S, Dry JR, Salahudeen AA, Khan AA, Lefkofsky E, Stumpe MC, Pelossof R. Privacy preserving validation for multiomic prediction models. Brief Bioinform. 2022 05 13; 23(3).
PMID: 35388408
Mendelian randomization supports bidirectional causality between telomere length and clonal hematopoiesis of indeterminate potential.
Nakao T, Bick AG, Taub MA, Zekavat SM, Uddin MM, Niroula A, Carty CL, Lane J, Honigberg MC, Weinstock JS, Pampana A, Gibson CJ, Griffin GK, Clarke SL, Bhattacharya R, Assimes TL, Emery LS, Stilp AM, Wong Q, Broome J, Laurie CA, Khan AT, Smith AV, Blackwell TW, Codd V, Nelson CP, Yoneda ZT, Peralta JM, Bowden DW, Irvin MR, Boorgula M, Zhao W, Yanek LR, Wiggins KL, Hixson JE, Gu CC, Peloso GM, Roden DM, Reupena MS, Hwu CM, DeMeo DL, North KE, Kelly S, Musani SK, Bis JC, Lloyd-Jones DM, Johnsen JM, Preuss M, Tracy RP, Peyser PA, Qiao D, Desai P, Curran JE, Freedman BI, Tiwari HK, Chavan S, Smith JA, Smith NL, Kelly TN, Hidalgo B, Cupples LA, Weeks DE, Hawley NL, Minster RL. Mendelian randomization supports bidirectional causality between telomere length and clonal hematopoiesis of indeterminate potential. Sci Adv. 2022 Apr 08; 8(14):eabl6579.
PMID: 35385311
A pan-cancer organoid platform for precision medicine.
A pan-cancer organoid platform for precision medicine. Cell Rep. 2021 07 27; 36(4):109429.
PMID: 34320344
Improved integration of single-cell transcriptome and surface protein expression by LinQ-View.
Improved integration of single-cell transcriptome and surface protein expression by LinQ-View. Cell Rep Methods. 2021 08 23; 1(4):100056.
PMID: 35475142
Innate-like self-reactive B cells infiltrate human renal allografts during transplant rejection.
Innate-like self-reactive B cells infiltrate human renal allografts during transplant rejection. Nat Commun. 2021 07 16; 12(1):4372.
PMID: 34272370
Validation of a liquid biopsy assay with molecular and clinical profiling of circulating tumor DNA.
Finkle JD, Boulos H, Driessen TM, Lo C, Blidner RA, Hafez A, Khan AA, Lozac'hmeur A, McKinnon KE, Perera J, Zhu W, Dowlati A, White KP, Tell R, Beaubier N. Validation of a liquid biopsy assay with molecular and clinical profiling of circulating tumor DNA. NPJ Precis Oncol. 2021 Jul 02; 5(1):63.
PMID: 34215841