My lab focuses on computational immunology and machine learning, with an emphasis on building predictive models of human immunology. We develop computational methods to understand immune responses across scales by analyzing both the molecular programs within immune cells and their interactions with the tissue microenvironment. Our goal is to uncover clinically relevant insights and pave the way for new diagnostics and therapies that can improve human health.
Spatial proximity sequencing maps developmental dynamics in the germinal center.
Spatial proximity sequencing maps developmental dynamics in the germinal center. Cell. 2026 Sep 17; 189(19):6153-6169.e5.
PMID: 42462709
AI-guided CRISPR screening reveals therapeutic targets in psoriasis.
AI-guided CRISPR screening reveals therapeutic targets in psoriasis. Nat Commun. 2026 Jul 06; 17(1).
PMID: 42409798
Deep peptide recognition profiling decodes TCR specificity and enables disease-associated antigen discovery.
Deep peptide recognition profiling decodes TCR specificity and enables disease-associated antigen discovery. Nat Biotechnol. 2026 May 13.
PMID: 42129507
Hybrid Computer Vision Model to Predict Lung Cancer in Diverse Populations.
Hybrid Computer Vision Model to Predict Lung Cancer in Diverse Populations. JCO Clin Cancer Inform. 2026 03; 10:e2500041.
PMID: 41855447
Virtual Cells Need Context, Not Just Scale.
Virtual Cells Need Context, Not Just Scale. bioRxiv. 2026 Feb 09.
PMID: 41727131
DecoderTCR: Compositional Pretraining and Entropy-Guided Decoding for TCR-pMHC Interactions.
DecoderTCR: Compositional Pretraining and Entropy-Guided Decoding for TCR-pMHC Interactions. bioRxiv. 2026 Feb 06.
PMID: 41676505
Integrating Polygenic Risk Improves Generative Forecasting of Disease Trajectories.
Integrating Polygenic Risk Improves Generative Forecasting of Disease Trajectories. Pac Symp Biocomput. 2026; 31:600-611.
PMID: 41758172
Large language models identify causal genes in complex trait GWAS.
Large language models identify causal genes in complex trait GWAS. Pac Symp Biocomput. 2026; 31:480-493.
PMID: 41758162
Recommendations for responsible use of population descriptors in polygenic risk score development.
Recommendations for responsible use of population descriptors in polygenic risk score development. Nat Genet. 2025 Dec; 57(12):2962-2971.
PMID: 41286102
Spatial Proximity Sequencing Maps Developmental Dynamics in the Germinal Center.
Spatial Proximity Sequencing Maps Developmental Dynamics in the Germinal Center. bioRxiv. 2025 Oct 28.
PMID: 41280071