Our Faculty

Antonio Bianco, MD PhD

Antonio Bianco is a physician-scientist working in the thyroid field. His studies have focused on how the systemic hormone T3 initiates or terminates critical biological steps while maintaining relatively stable levels in the circulation. As a graduate student, he discovered the molecular link between deiodination and thermogenesis, specifically that the UCP-1 gene, key for brown adipose tissue thermogenesis, is transcriptionally stimulated by T3. This finding inspired further research on how deiodinases can modify intracellular T3 levels and signaling without antecedent changes in plasma TH levels. Over the years, the work in his lab has established the importance of “local” control of TH metabolism provided by deiodinases. From a broad perspective, this work has inspired the modern paradigm that deiodinases regulate thyroid hormone signaling on a tissue-specific basis, playing critical roles in human health and disease. He also served in different administrative capacities and as President of the American Thyroid Association (2015-16).

University of Sao Paulo
Sao Paulo, Brazil
Ph.D. - Human Physiology
1988

Santa Casa School of Medicine
Sao Paulo, Brazil
M.D. - Medicine
1983

Inactivation of Type 3 Deiodinase Results in Life-long Changes in the Brown Adipose Tissue Transcriptome in the Male Mouse.
Fonseca TL, Russo SC, Luongo C, Salvatore D, Bianco AC. Inactivation of Type 3 Deiodinase Results in Life-long Changes in the Brown Adipose Tissue Transcriptome in the Male Mouse. Endocrinology. 2022 May 01; 163(5).
PMID: 35238380

The relevance of T3 in the management of hypothyroidism.
Salvatore D, Porcelli T, Ettleson MD, Bianco AC. The relevance of T3 in the management of hypothyroidism. Lancet Diabetes Endocrinol. 2022 Feb 28.
PMID: 35240052

Response to Letter to the Editor From Bonnema et al: "Comparative Effectiveness of Levothyroxine, Desiccated Thyroid Extract, and Levothyroxine + Liothyronine in Hypothyroidism".
Shakir MKM, Brooks DI, McAninch EA, Fonseca TL, Mai VQ, Bianco AC, Hoang TD. Response to Letter to the Editor From Bonnema et al: "Comparative Effectiveness of Levothyroxine, Desiccated Thyroid Extract, and Levothyroxine + Liothyronine in Hypothyroidism". J Clin Endocrinol Metab. 2022 02 17; 107(3):e1327-e1328.
PMID: 34718640

Heterozygote Advantage of the Type II deiodinase Thr92Ala Polymorphism on Intrahospital Mortality of COVID-19.
de Lima Beltrão FE, de Almeida Beltrão DC, Carvalhal G, de Lima Beltrão FE, Braga Filho JS, de Brito Oliveira J, de Jesus JDS, Machado GJR, Dos Santos Silva H, Teixeira HMP, Rodrigues JL, de Figueiredo CAV, Dos Santos Costa R, Hecht F, Bianco AC, Rodrigues Gonçalves MDC, Ramos HE. Heterozygote Advantage of the Type II deiodinase Thr92Ala Polymorphism on Intrahospital Mortality of COVID-19. J Clin Endocrinol Metab. 2022 Feb 09.
PMID: 35137147

Primary hypothyroidism and quality of life.
Hegedüs L, Bianco AC, Jonklaas J, Pearce SH, Weetman AP, Perros P. Primary hypothyroidism and quality of life. Nat Rev Endocrinol. 2022 Apr; 18(4):230-242.
PMID: 35042968

Extended Absorption of Liothyronine from Poly-Zinc-Liothyronine: Results from a Phase 1, Double-Blind, Randomized, and Controlled Study in Humans.
Dumitrescu AM, Hanlon EC, Arosemena M, Duchon O, Ettleson M, Giurcanu M, Bianco AC. Extended Absorption of Liothyronine from Poly-Zinc-Liothyronine: Results from a Phase 1, Double-Blind, Randomized, and Controlled Study in Humans. Thyroid. 2022 02; 32(2):196-205.
PMID: 34641706

Brain Fog in Hypothyroidism: Understanding the Patient's Perspective.
Ettleson MD, Raine A, Batistuzzo A, Batista SP, McAninch E, Teixeira MCTV, Jonklaas J, Laiteerapong N, Ribeiro MO, Bianco AC. Brain Fog in Hypothyroidism: Understanding the Patient's Perspective. Endocr Pract. 2022 Mar; 28(3):257-264.
PMID: 34890786

Response to Letter to the Editor from Steen Joop Bonnema: (Comparative Effectiveness of Levothyroxine, Desiccated Thyroid Extract, and Levothyroxine+Liothyronine in Hypothyroidism)".
Shakir MKM, Brooks DI, McAninch EA, Fonseca TL, Mai VQ, Bianco AC, Hoang TD. Response to Letter to the Editor from Steen Joop Bonnema: (Comparative Effectiveness of Levothyroxine, Desiccated Thyroid Extract, and Levothyroxine+Liothyronine in Hypothyroidism)". J Clin Endocrinol Metab. 2021 Oct 26.
PMID: 34718640

Comparative Effectiveness of Levothyroxine, Desiccated Thyroid Extract, and Levothyroxine+Liothyronine in Hypothyroidism.
Shakir MKM, Brooks DI, McAninch EA, Fonseca TL, Mai VQ, Bianco AC, Hoang TD. Comparative Effectiveness of Levothyroxine, Desiccated Thyroid Extract, and Levothyroxine+Liothyronine in Hypothyroidism. J Clin Endocrinol Metab. 2021 10 21; 106(11):e4400-e4413.
PMID: 34185829

Deiodinase-3 is a thyrostat to regulate podocyte homeostasis.
Agarwal S, Koh KH, Tardi NJ, Chen C, Dande RR, WerneckdeCastro JP, Sudhini YR, Luongo C, Salvatore D, Samelko B, Altintas MM, Mangos S, Bianco A, Reiser J. Deiodinase-3 is a thyrostat to regulate podocyte homeostasis. EBioMedicine. 2021 Oct; 72:103617.
PMID: 34649077

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President
American Thyroid Association
2015 - 2016

Rosalind Pitt-Rivers Medal
British Thyroid Association
2013

Membership
Association of American Physicians
2010

Membership
American Society for Clinical Investigation
2005

Van Meter Award
American Thyroid Association
2004

LATS Prize
Latin American Thyroid Society
2000

Manuel de Abreu Prize
Santa Casa School of Medicine
1983