Antonio Bianco is a physician-scientist working in the thyroid field. His studies have focused on how the systemic hormone T3 initiates or terminates critical biological steps while maintaining relatively stable levels in the circulation. As a graduate student, he discovered the molecular link between deiodination and thermogenesis, specifically that the UCP-1 gene, key for brown adipose tissue thermogenesis, is transcriptionally stimulated by T3. This finding inspired further research on how deiodinases can modify intracellular T3 levels and signaling without antecedent changes in plasma TH levels. Over the years, the work in his lab has established the importance of “local” control of TH metabolism provided by deiodinases. From a broad perspective, this work has inspired the modern paradigm that deiodinases regulate thyroid hormone signaling on a tissue-specific basis, playing critical roles in human health and disease. He also served in different administrative capacities and as President of the American Thyroid Association (2015-16).
University of Sao Paulo
Sao Paulo, Brazil
Ph.D. - Human Physiology
1988
Santa Casa School of Medicine
Sao Paulo, Brazil
M.D. - Medicine
1983
Sustained Pituitary T3 Production Explains the T4-mediated TSH Feedback Mechanism.
Sustained Pituitary T3 Production Explains the T4-mediated TSH Feedback Mechanism. Endocrinology. 2023 Nov 02; 164(12).
PMID: 37864846
A cross-sectional analysis of cardiovascular and bone healthcare utilization during treatment with thyroid hormone.
A cross-sectional analysis of cardiovascular and bone healthcare utilization during treatment with thyroid hormone. J Clin Endocrinol Metab. 2023 Oct 25.
PMID: 37878964
Localized T3 production modifies the transcriptome and promotes the hepatocyte-like lineage in iPSC-derived hepatic organoids.
Localized T3 production modifies the transcriptome and promotes the hepatocyte-like lineage in iPSC-derived hepatic organoids. JCI Insight. 2023 Oct 19.
PMID: 37856222
Gene polymorphisms and thyroid hormone signaling: implication for the treatment of hypothyroidism.
Gene polymorphisms and thyroid hormone signaling: implication for the treatment of hypothyroidism. Endocrine. 2023 Sep 23.
PMID: 37740833
Emerging Therapies in Hypothyroidism.
Emerging Therapies in Hypothyroidism. Annu Rev Med. 2023 Sep 22.
PMID: 37738506
The D2D3 form of uPAR acts as an immunotoxin and may cause diabetes and kidney disease.
The D2D3 form of uPAR acts as an immunotoxin and may cause diabetes and kidney disease. Sci Transl Med. 2023 09 20; 15(714):eabq6492.
PMID: 37729431
The Effects of Patient Characteristics on the Management of Subclinical Hypothyroidism: A Survey of Faculty and Trainees.
The Effects of Patient Characteristics on the Management of Subclinical Hypothyroidism: A Survey of Faculty and Trainees. Endocr Pract. 2023 Oct; 29(10):787-793.
PMID: 37549880
Levothyroxine Treatment Adequacy and Formulation Changes in Patients with Hypothyroidism: A Retrospective Study of Real-World Data from the United States.
Levothyroxine Treatment Adequacy and Formulation Changes in Patients with Hypothyroidism: A Retrospective Study of Real-World Data from the United States. Thyroid. 2023 08; 33(8):940-949.
PMID: 37335236
Are We Restoring Thyroid Hormone Signaling in Levothyroxine-Treated Patients With Residual Symptoms of Hypothyroidism?
Are We Restoring Thyroid Hormone Signaling in Levothyroxine-Treated Patients With Residual Symptoms of Hypothyroidism? Endocr Pract. 2023 Jul; 29(7):581-588.
PMID: 37419565
Demographic, healthcare access, and dietary factors associated with thyroid hormone treatments for hypothyroidism.
Demographic, healthcare access, and dietary factors associated with thyroid hormone treatments for hypothyroidism. J Clin Endocrinol Metab. 2023 Jun 16.
PMID: 37327351
President
American Thyroid Association
2015 - 2016
Rosalind Pitt-Rivers Medal
British Thyroid Association
2013
Membership
Association of American Physicians
2010
Membership
American Society for Clinical Investigation
2005
Van Meter Award
American Thyroid Association
2004
LATS Prize
Latin American Thyroid Society
2000
Manuel de Abreu Prize
Santa Casa School of Medicine
1983