Antonio Bianco is a physician-scientist working in the thyroid field. His studies have focused on how the systemic hormone T3 initiates or terminates critical biological steps while maintaining relatively stable levels in the circulation. As a graduate student, he discovered the molecular link between deiodination and thermogenesis, specifically that the UCP-1 gene, key for brown adipose tissue thermogenesis, is transcriptionally stimulated by T3. This finding inspired further research on how deiodinases can modify intracellular T3 levels and signaling without antecedent changes in plasma TH levels. Over the years, the work in his lab has established the importance of “local” control of TH metabolism provided by deiodinases. From a broad perspective, this work has inspired the modern paradigm that deiodinases regulate thyroid hormone signaling on a tissue-specific basis, playing critical roles in human health and disease. He also served in different administrative capacities and as President of the American Thyroid Association (2015-16).
University of Sao Paulo
Sao Paulo, Brazil
Ph.D. - Human Physiology
1988
Santa Casa School of Medicine
Sao Paulo, Brazil
M.D. - Medicine
1983
Thyroid hormone homeostasis in levothyroxine-treated patients: Findings from ELSA-Brasil.
Thyroid hormone homeostasis in levothyroxine-treated patients: Findings from ELSA-Brasil. J Clin Endocrinol Metab. 2024 Mar 20.
PMID: 38506164
Impaired T3 uptake and action in MCT8-deficient cerebral organoids underlie Allan-Herndon-Dudley syndrome.
Impaired T3 uptake and action in MCT8-deficient cerebral organoids underlie Allan-Herndon-Dudley syndrome. JCI Insight. 2024 Feb 20; 9(7).
PMID: 38376950
A Cross-Sectional Analysis of Cardiovascular and Bone Health Care Utilization During Treatment With Thyroid Hormone.
A Cross-Sectional Analysis of Cardiovascular and Bone Health Care Utilization During Treatment With Thyroid Hormone. J Clin Endocrinol Metab. 2024 Feb 20; 109(3):e1143-e1150.
PMID: 37878964
Editorial: (Re)defining hypothyroidism: the key to patient-centered treatment.
Editorial: (Re)defining hypothyroidism: the key to patient-centered treatment. Front Endocrinol (Lausanne). 2024; 15:1369723.
PMID: 38379867
Localized T3 production modifies the transcriptome and promotes the hepatocyte-like lineage in iPSC-derived hepatic organoids.
Localized T3 production modifies the transcriptome and promotes the hepatocyte-like lineage in iPSC-derived hepatic organoids. JCI Insight. 2023 Dec 08; 8(23).
PMID: 37856222
Demographic, Healthcare Access, and Dietary Factors Associated With Thyroid Hormone Treatments for Hypothyroidism.
Demographic, Healthcare Access, and Dietary Factors Associated With Thyroid Hormone Treatments for Hypothyroidism. J Clin Endocrinol Metab. 2023 Nov 17; 108(12):e1614-e1623.
PMID: 37327351
Sustained Pituitary T3 Production Explains the T4-mediated TSH Feedback Mechanism.
Sustained Pituitary T3 Production Explains the T4-mediated TSH Feedback Mechanism. Endocrinology. 2023 11 02; 164(12).
PMID: 37864846
A cross-sectional analysis of cardiovascular and bone healthcare utilization during treatment with thyroid hormone.
A cross-sectional analysis of cardiovascular and bone healthcare utilization during treatment with thyroid hormone. J Clin Endocrinol Metab. 2023 Oct 25.
PMID: 37878964
Gene polymorphisms and thyroid hormone signaling: implication for the treatment of hypothyroidism.
Gene polymorphisms and thyroid hormone signaling: implication for the treatment of hypothyroidism. Endocrine. 2023 Sep 23.
PMID: 37740833
Emerging Therapies in Hypothyroidism.
Emerging Therapies in Hypothyroidism. Annu Rev Med. 2024 Jan 29; 75:307-319.
PMID: 37738506
President
American Thyroid Association
2015 - 2016
Rosalind Pitt-Rivers Medal
British Thyroid Association
2013
Membership
Association of American Physicians
2010
Membership
American Society for Clinical Investigation
2005
Van Meter Award
American Thyroid Association
2004
LATS Prize
Latin American Thyroid Society
2000
Manuel de Abreu Prize
Santa Casa School of Medicine
1983