Antonio Bianco is a physician-scientist working in the thyroid field. His studies have focused on how the systemic hormone T3 initiates or terminates critical biological steps while maintaining relatively stable levels in the circulation. As a graduate student, he discovered the molecular link between deiodination and thermogenesis, specifically that the UCP-1 gene, key for brown adipose tissue thermogenesis, is transcriptionally stimulated by T3. This finding inspired further research on how deiodinases can modify intracellular T3 levels and signaling without antecedent changes in plasma TH levels. Over the years, the work in his lab has established the importance of “local” control of TH metabolism provided by deiodinases. From a broad perspective, this work has inspired the modern paradigm that deiodinases regulate thyroid hormone signaling on a tissue-specific basis, playing critical roles in human health and disease. He also served in different administrative capacities and as President of the American Thyroid Association (2015-16).
University of Sao Paulo
Sao Paulo, Brazil
Ph.D. - Human Physiology
1988
Santa Casa School of Medicine
Sao Paulo, Brazil
M.D. - Medicine
1983
Optimizing the treatment of hypothyroidism.
Optimizing the treatment of hypothyroidism. Nat Rev Endocrinol. 2024 Jul; 20(7):379-380.
PMID: 38684871
The Musashi-1-type 2 deiodinase pathway regulates astrocyte proliferation.
The Musashi-1-type 2 deiodinase pathway regulates astrocyte proliferation. J Biol Chem. 2024 Jun 13; 300(7):107477.
PMID: 38879014
Thr92Ala-DIO2 heterozygosity is associated with skeletal muscle mass and myosteatosis in patients with COVID-19.
Thr92Ala-DIO2 heterozygosity is associated with skeletal muscle mass and myosteatosis in patients with COVID-19. Eur Thyroid J. 2024 Jun 01.
PMID: 38869458
Genetic Background Strongly Influences the Impact of Carrying the Thr92Ala-DIO2 Polymorphism in the Male Mouse.
Genetic Background Strongly Influences the Impact of Carrying the Thr92Ala-DIO2 Polymorphism in the Male Mouse. Endocrinology. 2024 May 27; 165(7).
PMID: 38836615
TSH Trajectories During Levothyroxine Treatment in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) Cohort.
TSH Trajectories During Levothyroxine Treatment in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) Cohort. J Clin Endocrinol Metab. 2024 May 23.
PMID: 38780968
A Scholarly Dialog on Recent Trends in National Institutes of Health's Funding for the Thyroid Field.
A Scholarly Dialog on Recent Trends in National Institutes of Health's Funding for the Thyroid Field. Thyroid. 2024 May 02.
PMID: 38661525
Thyroid hormone homeostasis in levothyroxine-treated patients: Findings from ELSA-Brasil.
Thyroid hormone homeostasis in levothyroxine-treated patients: Findings from ELSA-Brasil. J Clin Endocrinol Metab. 2024 Mar 20.
PMID: 38506164
A Cross-Sectional Analysis of Cardiovascular and Bone Health Care Utilization During Treatment With Thyroid Hormone.
A Cross-Sectional Analysis of Cardiovascular and Bone Health Care Utilization During Treatment With Thyroid Hormone. J Clin Endocrinol Metab. 2024 Feb 20; 109(3):e1143-e1150.
PMID: 37878964
Impaired T3 uptake and action in MCT8-deficient cerebral organoids underlie Allan-Herndon-Dudley syndrome.
Impaired T3 uptake and action in MCT8-deficient cerebral organoids underlie Allan-Herndon-Dudley syndrome. JCI Insight. 2024 Feb 20; 9(7).
PMID: 38376950
Editorial: (Re)defining hypothyroidism: the key to patient-centered treatment.
Editorial: (Re)defining hypothyroidism: the key to patient-centered treatment. Front Endocrinol (Lausanne). 2024; 15:1369723.
PMID: 38379867
President
American Thyroid Association
2015 - 2016
Rosalind Pitt-Rivers Medal
British Thyroid Association
2013
Membership
Association of American Physicians
2010
Membership
American Society for Clinical Investigation
2005
Van Meter Award
American Thyroid Association
2004
LATS Prize
Latin American Thyroid Society
2000
Manuel de Abreu Prize
Santa Casa School of Medicine
1983