Our Faculty

Antonio Bianco, MD PhD

Antonio Bianco is a physician-scientist working in the thyroid field. His studies have focused on how the systemic hormone T3 initiates or terminates critical biological steps while maintaining relatively stable levels in the circulation. As a graduate student, he discovered the molecular link between deiodination and thermogenesis, specifically that the UCP-1 gene, key for brown adipose tissue thermogenesis, is transcriptionally stimulated by T3. This finding inspired further research on how deiodinases can modify intracellular T3 levels and signaling without antecedent changes in plasma TH levels. Over the years, the work in his lab has established the importance of “local” control of TH metabolism provided by deiodinases. From a broad perspective, this work has inspired the modern paradigm that deiodinases regulate thyroid hormone signaling on a tissue-specific basis, playing critical roles in human health and disease. He also served in different administrative capacities and as President of the American Thyroid Association (2015-16).

University of Sao Paulo
Sao Paulo, Brazil
Ph.D. - Human Physiology
1988

Santa Casa School of Medicine
Sao Paulo, Brazil
M.D. - Medicine
1983

Serum Thyrotropin and Triiodothyronine Levels in Levothyroxine-Treated Patients.
Serum Thyrotropin and Triiodothyronine Levels in Levothyroxine-Treated Patients. J Clin Endocrinol Metab. 2022 Dec 14.
PMID: 36515655

Different Hypothalamic Mechanisms Control Decreased Circulating Thyroid Hormone Levels in Infection and Fasting-Induced Non-Thyroidal Illness Syndrome in Male Thyroid Hormone Action Indicator Mice.
Different Hypothalamic Mechanisms Control Decreased Circulating Thyroid Hormone Levels in Infection and Fasting-Induced Non-Thyroidal Illness Syndrome in Male Thyroid Hormone Action Indicator Mice. Thyroid. 2023 01; 33(1):109-118.
PMID: 36322711

T3 levels and thyroid hormone signaling.
T3 levels and thyroid hormone signaling. Front Endocrinol (Lausanne). 2022; 13:1044691.
PMID: 36387853

Enhancing the Patient Voice: Quality of Life, Satisfaction, and Preference During Treatment of Hypothyroidism.
Enhancing the Patient Voice: Quality of Life, Satisfaction, and Preference During Treatment of Hypothyroidism. Thyroid. 2022 Oct; 32(10):1139-1141.
PMID: 36136911

Multisensory Stimulation Improves Cognition and Behavior in Adult Male Rats Born to LT4-treated Thyroidectomized Dams.
Multisensory Stimulation Improves Cognition and Behavior in Adult Male Rats Born to LT4-treated Thyroidectomized Dams. Endocrinology. 2022 09 01; 163(9).
PMID: 35914267

Suboptimal Thyroid Hormone Replacement Is Associated With Worse Hospital Outcomes.
Suboptimal Thyroid Hormone Replacement Is Associated With Worse Hospital Outcomes. J Clin Endocrinol Metab. 2022 07 14; 107(8):e3411-e3419.
PMID: 35472082

Age Worsens the Cognitive Phenotype in Mice Carrying the Thr92Ala-DIO2 Polymorphism.
Age Worsens the Cognitive Phenotype in Mice Carrying the Thr92Ala-DIO2 Polymorphism. Metabolites. 2022 Jul 08; 12(7).
PMID: 35888752

Selpercatinib-Induced Hypothyroidism Through Off-Target Inhibition of Type 2 Iodothyronine Deiodinase.
Selpercatinib-Induced Hypothyroidism Through Off-Target Inhibition of Type 2 Iodothyronine Deiodinase. JCO Precis Oncol. 2022 06; 6:e2100496.
PMID: 35704797

Heterozygote Advantage of the Type II Deiodinase Thr92Ala Polymorphism on Intrahospital Mortality of COVID-19.
Heterozygote Advantage of the Type II Deiodinase Thr92Ala Polymorphism on Intrahospital Mortality of COVID-19. J Clin Endocrinol Metab. 2022 05 17; 107(6):e2488-e2501.
PMID: 35137147

Inactivation of Type 3 Deiodinase Results in Life-long Changes in the Brown Adipose Tissue Transcriptome in the Male Mouse.
Inactivation of Type 3 Deiodinase Results in Life-long Changes in the Brown Adipose Tissue Transcriptome in the Male Mouse. Endocrinology. 2022 05 01; 163(5).
PMID: 35238380

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President
American Thyroid Association
2015 - 2016

Rosalind Pitt-Rivers Medal
British Thyroid Association
2013

Membership
Association of American Physicians
2010

Membership
American Society for Clinical Investigation
2005

Van Meter Award
American Thyroid Association
2004

LATS Prize
Latin American Thyroid Society
2000

Manuel de Abreu Prize
Santa Casa School of Medicine
1983