Our Faculty

Cassandra Hayne

National Institute of Environmental Health Sciences
RTP, NC
Postdoctoral Fellowship - Biochemistry & Structural Biology
2022

University of North Carolina at Chapel Hill
Chapel Hill, NC
Ph.D. - Biochemistry
2017

University of Northern Iowa
Cedar Falls, IA
B.A./B.S. - Biochemistry & Biology
2011

The making and breaking of tRNAs by ribonucleases.
The making and breaking of tRNAs by ribonucleases. Trends Genet. 2024 Jun; 40(6):511-525.
PMID: 38641471

Author Correction: Structural basis for pre-tRNA recognition and processing by the human tRNA splicing endonuclease complex.
Author Correction: Structural basis for pre-tRNA recognition and processing by the human tRNA splicing endonuclease complex. Nat Struct Mol Biol. 2024 Feb; 31(2):390.
PMID: 38196035

New insights into RNA processing by the eukaryotic tRNA splicing endonuclease.
New insights into RNA processing by the eukaryotic tRNA splicing endonuclease. J Biol Chem. 2023 09; 299(9):105138.
PMID: 37544645

Structural basis for pre-tRNA recognition and processing by the human tRNA splicing endonuclease complex.
Structural basis for pre-tRNA recognition and processing by the human tRNA splicing endonuclease complex. Nat Struct Mol Biol. 2023 06; 30(6):824-833.
PMID: 37231153

Recent insights into the structure, function, and regulation of the eukaryotic transfer RNA splicing endonuclease complex.
Recent insights into the structure, function, and regulation of the eukaryotic transfer RNA splicing endonuclease complex. Wiley Interdiscip Rev RNA. 2022 09; 13(5):e1717.
PMID: 35156311

Cryo-EM structures of the SARS-CoV-2 endoribonuclease Nsp15 reveal insight into nuclease specificity and dynamics.
Cryo-EM structures of the SARS-CoV-2 endoribonuclease Nsp15 reveal insight into nuclease specificity and dynamics. Nat Commun. 2021 01 27; 12(1):636.
PMID: 33504779

Reconstitution of the human tRNA splicing endonuclease complex: insight into the regulation of pre-tRNA cleavage.
Reconstitution of the human tRNA splicing endonuclease complex: insight into the regulation of pre-tRNA cleavage. Nucleic Acids Res. 2020 08 20; 48(14):7609-7622.
PMID: 32476018

Cryo-EM Structures of the SARS-CoV-2 Endoribonuclease Nsp15.
Pillon MC, Frazier MN, Dillard LB, Williams JG, Kocaman S, Krahn JM, Perera L, Hayne CK, Gordon J, Stewart ZD, Sobhany M, Deterding LJ, Hsu AL, Dandey VP, Borgnia MJ, Stanley RE. Cryo-EM Structures of the SARS-CoV-2 Endoribonuclease Nsp15. bioRxiv. 2020 Aug 11.
PMID: 32803198

We FRET so You Don't Have To: New Models of the Lipoprotein Lipase Dimer.
We FRET so You Don't Have To: New Models of the Lipoprotein Lipase Dimer. Biochemistry. 2018 01 16; 57(2):241-254.
PMID: 29303250

Biochemical Analysis of the Lipoprotein Lipase Truncation Variant, LPLS447X, Reveals Increased Lipoprotein Uptake.
Biochemical Analysis of the Lipoprotein Lipase Truncation Variant, LPLS447X, Reveals Increased Lipoprotein Uptake. Biochemistry. 2017 01 24; 56(3):525-533.
PMID: 27984852

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MOSAIC K99/R00
NIGMS/NIH
2021

Graduate Research Fellowship
NSF
2013