Shortly after the discovery of antibiotics in the early to mid 20th century, bacteria have developed resistance to them. Now, antibiotics that were once considered medical miracles have been relegated to obscurity by wide spread resistance. Even the most advanced broad spectrum antibiotics are failing because of resistance. Our current path of new drug discovery followed by development of resistant bacteria is resulting in ever increasing antibiotic resistance, meanwhile infections and deaths caused by drug resistant pathogens only rises.
Before humans learned to use antibiotics, the healthy bacteria living with us (our microbiome) were in a constant state of competition and cooperation. In this state, healthy bacteria competed against harmful ones and prevented infection. When antibiotics are introduced, the healthy bacteria are killed, drug resistant harmful bacteria bloom, and they cause deadly infections.
Guided by an ever growing understanding of the human microbiome, I am working to restore and defend the beneficial bacteria of the microbiome. This strategy will restore the microbiome back to health and add to the arsenal in our fight against antibiotic resistant infections.
University of Chicago
Chicago, IL
- Adult and Pediatric Infectious Disease Fellowship
2023
Indiana University
Indianapolis, IN
- Internal Medicine and Pediatrics Residency
2019
Indiana University
Indianapolis, IN
MD - Medicine
2015
Colorado State University
Fort Collins, CO
BS - Microbiology/Biochemistry
2011
Fecal metabolite profiling identifies liver transplant recipients at risk for postoperative infection.
Fecal metabolite profiling identifies liver transplant recipients at risk for postoperative infection. Cell Host Microbe. 2024 Jan 10; 32(1):117-130.e4.
PMID: 38103544
Bifidobacteria metabolize lactulose to optimize gut metabolites and prevent systemic infection in patients with liver disease.
Bifidobacteria metabolize lactulose to optimize gut metabolites and prevent systemic infection in patients with liver disease. Nat Microbiol. 2023 Nov; 8(11):2033-2049.
PMID: 37845315
Immunomodulatory fecal metabolites are associated with mortality in COVID-19 patients with respiratory failure.
Immunomodulatory fecal metabolites are associated with mortality in COVID-19 patients with respiratory failure. Nat Commun. 2022 11 03; 13(1):6615.
PMID: 36329015
Translating Microbiome Research From and To the Clinic.
Translating Microbiome Research From and To the Clinic. Annu Rev Microbiol. 2022 09 08; 76:435-460.
PMID: 35655344
Cancer, transplant, and immunocompromising conditions were not significantly associated with severe illness or death in hospitalized COVID-19 patients.
Cancer, transplant, and immunocompromising conditions were not significantly associated with severe illness or death in hospitalized COVID-19 patients. J Clin Virol. 2021 07; 140:104850.
PMID: 34022753
Community-acquired Coinfection in Coronavirus Disease 2019: A Retrospective Observational Experience.
Community-acquired Coinfection in Coronavirus Disease 2019: A Retrospective Observational Experience. Clin Infect Dis. 2021 04 26; 72(8):1450-1452.
PMID: 32604413
Notes from the Field: Cronobacter sakazakii Meningitis in a Full-Term Neonate Fed Exclusively with Breast Milk - Indiana, 2018.
Notes from the Field: Cronobacter sakazakii Meningitis in a Full-Term Neonate Fed Exclusively with Breast Milk - Indiana, 2018. MMWR Morb Mortal Wkly Rep. 2018 Nov 09; 67(44):1248-1249.
PMID: 30408018
Apical Lung Herniation Associated with Continuous Positive Airway Pressure in a 4-Year-Old Girl.
Apical Lung Herniation Associated with Continuous Positive Airway Pressure in a 4-Year-Old Girl. J Clin Sleep Med. 2016 11 15; 12(11):1565-1566.
PMID: 27397657
Reply to Sun et al.: Deposition of organic nitrogen.
Reply to Sun et al.: Deposition of organic nitrogen. Proc Natl Acad Sci U S A. 2016 08 02; 113(31):E4435.
PMID: 27439877
Evaluation of the Impact of National HIV Testing Day - United States, 2011-2014.
Evaluation of the Impact of National HIV Testing Day - United States, 2011-2014. MMWR Morb Mortal Wkly Rep. 2016 Jun 24; 65(24):613-8.
PMID: 27336946
Fellow
American Academy of Pediatrics
2022
Alpha Omega Alpha
2014