Dr. Weber is an expert in the biophysical properties of the tight junctions and focuses on defining mechanisms of claudin barrier regulation in health and disease.
A second focus of Dr. Weber's lab is cardiac cellular electrophysiology, with an emphasis on mechanisms of abnormal cellular calcium handling in disease.
University of Chicago Medicine
Fellowship - Gastrointestinal Pathology
2010
University of Chicago Medicine
Residency - Anatomic Pathology
2007
Loyola University Chicago, Stritch School of Medicine
MD, PhD - Physiology
2004
FUT2 non-secretor status is not associated with disease phenotype or outcomes in patients with Crohn's disease.
FUT2 non-secretor status is not associated with disease phenotype or outcomes in patients with Crohn's disease. Crohns Colitis 360. 2026 Jul; 8(3):otag094.
PMID: 42662997
Global Roll-Out and Continued Multi-Site Validation of the Artificial Intelligence Histology Instrument for Qualitative Assessment of Histopathology in Ulcerative Colitis.
Global Roll-Out and Continued Multi-Site Validation of the Artificial Intelligence Histology Instrument for Qualitative Assessment of Histopathology in Ulcerative Colitis. United European Gastroenterol J. 2026 Jul; 14(6):e70227.
PMID: 42390952
Cryo-electron tomography reveals paracellular claudin-15 pores at the tight junction.
Cryo-electron tomography reveals paracellular claudin-15 pores at the tight junction. Biophys J. 2026 08 04; 125(15):3787-3792.
PMID: 42343561
Inflammation-Induced Claudin-2 Up-Regulation Limits Pancreatitis Development by Enhancing Pancreatic Ductal Transport.
Inflammation-Induced Claudin-2 Up-Regulation Limits Pancreatitis Development by Enhancing Pancreatic Ductal Transport. Gastroenterology. 2026 Oct; 171(4):699-716.
PMID: 42142543
Glutamine-dependent changes in fibroblast-derived extracellular matrix dictate cancer cell behavior.
Glutamine-dependent changes in fibroblast-derived extracellular matrix dictate cancer cell behavior. Matrix Biol. 2026 Jun; 146:102003.
PMID: 41895622
Cryo-electron tomography reveals paracellular claudin-15 pores at the tight junction.
Cryo-electron tomography reveals paracellular claudin-15 pores at the tight junction. bioRxiv. 2026 Feb 20.
PMID: 41757056
Molecular dynamics analyses of CLDN15 pore size and charge selectivity.
Molecular dynamics analyses of CLDN15 pore size and charge selectivity. J Gen Physiol. 2026 Mar 02; 158(2).
PMID: 41677678
Colonic Tissue Expression of MAdCAM-1 Is Not Predictive of Vedolizumab Responsiveness in Inflammatory Bowel Disease.
Colonic Tissue Expression of MAdCAM-1 Is Not Predictive of Vedolizumab Responsiveness in Inflammatory Bowel Disease. Clin Transl Sci. 2025 12; 18(12):e70422.
PMID: 41277578
Tumor nutrient stress gives rise to a drug tolerant cell state in pancreatic cancer.
Tumor nutrient stress gives rise to a drug tolerant cell state in pancreatic cancer. bioRxiv. 2025 Sep 08.
PMID: 40964288
Histopathologic Evaluation and Single-cell Spatial Transcriptomics of the Colon Reveal Cellular and Molecular Abnormalities Linked to J-Pouch Failure in Patients With Inflammatory Bowel Disease.
Histopathologic Evaluation and Single-cell Spatial Transcriptomics of the Colon Reveal Cellular and Molecular Abnormalities Linked to J-Pouch Failure in Patients With Inflammatory Bowel Disease. Cell Mol Gastroenterol Hepatol. 2025; 19(10):101563.
PMID: 40571096