Dr. Drummond is an Associate Professor of Biochemistry & Molecular Biology and Human Genetics. His group studies how cells respond to stress at the molecular level, focusing on formation and dissolution of large assemblies of proteins and RNA during and after stresses such as heat shock. Drummond's lab uses a wide range of techniques, including in vivo imaging, in vitro reconstitution and mechanistic biochemistry, quantitative proteomics, and molecular evolutionary analyses. Because many features of stress-triggered assembly processes are shared across eukaryotes, including humans, the group employs budding yeast, Saccharomyces cerevisiae, as a model organism.
Harvard University
Cambridge, MA
- Systems biology
2011
California Institute of Technology
Pasadena, CA
Ph.D. - Computation and neural systems
2006
Princeton University
Princeton, NJ
B.S.E. - Mechanical and aerospace engineering
1995
Chaperones directly and efficiently disperse stress-triggered biomolecular condensates.
Chaperones directly and efficiently disperse stress-triggered biomolecular condensates. Mol Cell. 2022 02 17; 82(4):741-755.e11.
PMID: 35148816
Author Correction: Reversible amyloids of pyruvate kinase couple cell metabolism and stress granule disassembly.
Author Correction: Reversible amyloids of pyruvate kinase couple cell metabolism and stress granule disassembly. Nat Cell Biol. 2022 Jan; 24(1):123.
PMID: 34702981
Reversible amyloids of pyruvate kinase couple cell metabolism and stress granule disassembly.
Reversible amyloids of pyruvate kinase couple cell metabolism and stress granule disassembly. Nat Cell Biol. 2021 10; 23(10):1085-1094.
PMID: 34616026
Daily Cycles of Reversible Protein Condensation in Cyanobacteria.
Daily Cycles of Reversible Protein Condensation in Cyanobacteria. Cell Rep. 2020 08 18; 32(7):108032.
PMID: 32814039
Transient intracellular acidification regulates the core transcriptional heat shock response.
Transient intracellular acidification regulates the core transcriptional heat shock response. Elife. 2020 08 07; 9.
PMID: 32762843
Live Cell Measurement of the Intracellular pH of Yeast by Flow Cytometry Using a Genetically-Encoded Fluorescent Reporter.
Live Cell Measurement of the Intracellular pH of Yeast by Flow Cytometry Using a Genetically-Encoded Fluorescent Reporter. Bio Protoc. 2020 Jun 20; 10(12):e3653.
PMID: 33659323
Cellular sensing by phase separation: Using the process, not just the products.
Cellular sensing by phase separation: Using the process, not just the products. J Biol Chem. 2019 05 03; 294(18):7151-7159.
PMID: 30877200
An Escherichia coli Nitrogen Starvation Response Is Important for Mutualistic Coexistence with Rhodopseudomonas palustris.
An Escherichia coli Nitrogen Starvation Response Is Important for Mutualistic Coexistence with Rhodopseudomonas palustris. Appl Environ Microbiol. 2018 07 15; 84(14).
PMID: 29728387
Stress-Triggered Phase Separation Is an Adaptive, Evolutionarily Tuned Response.
Stress-Triggered Phase Separation Is an Adaptive, Evolutionarily Tuned Response. Cell. 2017 03 09; 168(6):1028-1040.e19.
PMID: 28283059
Heat Shock Factor 1: From Fire Chief to Crowd-Control Specialist.
Heat Shock Factor 1: From Fire Chief to Crowd-Control Specialist. Mol Cell. 2016 07 07; 63(1):1-2.
PMID: 27392142
Pew Scholar in the Biomedical Sciences
Pew Charitable Trusts
2012 - 2016
Sloan Research Fellow
Alfred P. Sloan Foundation
2012 - 2014
Bauer Fellow
Harvard University
2006 - 2011