Divergent roles of m6A in orchestrating brown and white adipocyte transcriptomes and systemic metabolism.
Divergent roles of m6A in orchestrating brown and white adipocyte transcriptomes and systemic metabolism. Nat Commun. 2025 Jan 09; 16(1):533.
PMID: 39788955
m6A mRNA methylation by METTL14 regulates early pancreatic cell differentiation.
m6A mRNA methylation by METTL14 regulates early pancreatic cell differentiation. EMBO J. 2024 Nov; 43(22):5445-5468.
PMID: 39322760
m6A mRNA methylation in brown fat regulates systemic insulin sensitivity via an inter-organ prostaglandin signaling axis independent of UCP1.
m6A mRNA methylation in brown fat regulates systemic insulin sensitivity via an inter-organ prostaglandin signaling axis independent of UCP1. Cell Metab. 2024 Oct 01; 36(10):2207-2227.e9.
PMID: 39255799
SUCNR1 regulates insulin secretion and glucose elevates the succinate response in people with prediabetes.
SUCNR1 regulates insulin secretion and glucose elevates the succinate response in people with prediabetes. J Clin Invest. 2024 May 07; 134(12).
PMID: 38713514
Redox regulation of m6A methyltransferase METTL3 in ß-cells controls the innate immune response in type 1 diabetes.
Redox regulation of m6A methyltransferase METTL3 in ß-cells controls the innate immune response in type 1 diabetes. Nat Cell Biol. 2024 Mar; 26(3):421-437.
PMID: 38409327
Fluorescein-based sensors to purify human a-cells for functional and transcriptomic analyses.
Fluorescein-based sensors to purify human a-cells for functional and transcriptomic analyses. Elife. 2023 Sep 21; 12.
PMID: 37732504
m 6 A mRNA Methylation Regulates Early Pancreatic ß-Cell Differentiation.
m 6 A mRNA Methylation Regulates Early Pancreatic ß-Cell Differentiation. bioRxiv. 2023 Aug 03.
PMID: 37577492
Deficiency of the metabolic enzyme SCHAD in pancreatic ß-cells promotes amino acid-sensitive hypoglycemia.
Deficiency of the metabolic enzyme SCHAD in pancreatic ß-cells promotes amino acid-sensitive hypoglycemia. J Biol Chem. 2023 08; 299(8):104986.
PMID: 37392854
NREP contributes to development of NAFLD by regulating one-carbon metabolism in primary human hepatocytes.
NREP contributes to development of NAFLD by regulating one-carbon metabolism in primary human hepatocytes. Cell Chem Biol. 2023 09 21; 30(9):1144-1155.e4.
PMID: 37354909
Excess pancreatic elastase alters acinar-ß cell communication by impairing the mechano-signaling and the PAR2 pathways.
Excess pancreatic elastase alters acinar-ß cell communication by impairing the mechano-signaling and the PAR2 pathways. Cell Metab. 2023 07 11; 35(7):1242-1260.e9.
PMID: 37339634