Dr. Claud is a physician scientist who intended to be a full time clinician but discovered a passion for answering questions through laboratory investigation. She is committed to the questions being explored in her laboratory but also to encouraging medical students and trainees to consider research as an essential and feasible means of improving patient care.
Dr. Claud is a Professor in the Department of Pediatrics, Section of Neonatology, and the Department of Medicine, Section of Gastroenterology. She received her combined undergraduate and medical degree at Northwestern University through the six year Honors Program in Medical Education, and then completed her Residency in Pediatrics at Children’s Memorial Hospital in Chicago. After spending 18 months in rural Kenya as a missionary physician, she returned to Chicago to complete her Neonatology Fellowship at Children’s Memorial Hospital.
Following her clinical fellowship she was recruited to Harvard Medical School where she held a clinical position at The Boston Children’s Hospital and completed a research fellowship at Massachusetts General Hospital. She joined the faculty of the University of Chicago in 2004. She is NIH funded to investigate the role of microbes in intestinal development of the preterm infant and leads the MIND (Microbiome in Neonatal Development) cohort. The interaction between the intestine and its resident microbiota is a complex relationship with risk and benefit for the host. Perturbations in environmental cues or altered patterns of microbial selection can affect health and increase risk of disease in susceptible individuals. The simple microbial communities and limited environmental variation of the preterm infant provide a unique model in which to investigate microbial perturbations. Her laboratory utilizes state-of-the-art experimental approaches including: 16S rRNA and shotgun metagenomic analyses of the microbiome, gnotobiotic mouse models, rodent models of Neonatal Necrotizing Enterocolitis, as well as cell culture models of immature and mature intestine to investigate the health impact of the microbiome on health outcomes of preterm infants.
She is co-director of the Basic Science Track within the Scholarship and Discovery Program of the Pritzker School of Medicine and Faculty Co-Chair Pritzker School of Medicine Summer Research Program. She is also Director of Neonatology Research and a member of the Faculty Leadership Cabinet for the Duchossois Family Institute.
Massachusetts General Hospital
Boston, MA
Research Fellowship
2003
Children's Memorial Hospital
Chicago, IL
Fellowship - Neonatology
2000
Children's Memorial Hospital
Chicago, IL
Internship and Residency - Pediatrics
1993
Northwestern Feinberg School of Medicine
Chicago, IL
MD - Medicine
1990
Northwestern University
Evanston, IL
BS - Medicine
1988
Early preterm infant microbiome impacts adult learning.
Lu J, Lu L, Yu Y, Oliphant K, Drobyshevsky A, Claud EC. Early preterm infant microbiome impacts adult learning. Sci Rep. 2022 02 28; 12(1):3310.
PMID: 35228616
The Role of Childhood Asthma in Obesity Development: A Nationwide US Multicohort Study.
Stratakis N, Garcia E, Chandran A, Hsu T, Alshawabkeh A, Aris IM, Aschner JL, Breton C, Burbank A, Camargo CA, Carroll KN, Chen Z, Claud EC, Dabelea D, Dunlop AL, Elliott AJ, Ferrara A, Ganiban JM, Gern JE, Gold DR, Gower WA, Hertz-Picciotto I, Karagas MR, Karr CJ, Lester B, Leve LD, Litonjua AA, Ludena Y, McEvoy CT, Miller RL, Mueller NT, O'Connor TG, Oken E, O'Shea TM, Perera F, Stanford JB, Rivera-Spoljaric K, Rundle A, Trasande L, Wright RJ, Zhang Y, Zhu Y, Berhane K, Gilliland F, Chatzi L. The Role of Childhood Asthma in Obesity Development: A Nationwide US Multicohort Study. Epidemiology. 2022 01 01; 33(1):131-140.
PMID: 34561347
The Role of Childhood Asthma in Obesity Development: A Nationwide U.S. Multi-cohort Study.
Stratakis N, Garcia E, Chandran A, Hsu T, Alshawabkeh A, Aris IM, Aschner JL, Breton C, Burbank A, Camargo CA, Carroll KN, Chen Z, Claud EC, Dabelea D, Dunlop AL, Elliott AJ, Ferrara A, Ganiban JM, Gern JE, Gold DR, Gower WA, Hertz-Picciotto I, Karagas MR, Karr CJ, Lester B, Leve LD, Litonjua AA, Ludena Y, McEvoy CT, Miller RL, Mueller NT, O'Connor TG, Oken E, O'Shea TM, Perera F, Stanford JB, Rivera-Spoljaric K, Rundle A, Trasande L, Wright RJ, Zhang Y, Zhu Y, Berhane K, Gilliland F, Chatzi L. The Role of Childhood Asthma in Obesity Development: A Nationwide U.S. Multi-cohort Study. Epidemiology. 2021 Sep 20.
PMID: 34561347
The microbiome, guard or threat to infant health.
Walls Castellanos M, Claud EC. The microbiome, guard or threat to infant health. Trends Mol Med. 2021 12; 27(12):1175-1186.
PMID: 34518093
The human gut microbiome and health inequities.
Amato KR, Arrieta MC, Azad MB, Bailey MT, Broussard JL, Bruggeling CE, Claud EC, Costello EK, Davenport ER, Dutilh BE, Swain Ewald HA, Ewald P, Hanlon EC, Julion W, Keshavarzian A, Maurice CF, Miller GE, Preidis GA, Segurel L, Singer B, Subramanian S, Zhao L, Kuzawa CW. The human gut microbiome and health inequities. Proc Natl Acad Sci U S A. 2021 06 22; 118(25).
PMID: 34161260
Epigenome - A mediator for host-microbiome crosstalk.
Peery RC, Pammi M, Claud E, Shen L. Epigenome - A mediator for host-microbiome crosstalk. Semin Perinatol. 2021 10; 45(6):151455.
PMID: 34246487
Effect of Antibiotic Use Within First 48 Hours of Life on the Preterm Infant Microbiome: A Randomized Clinical Trial.
Kim CS, Grady N, Derrick M, Yu Y, Oliphant K, Lu J, Claud EC. Effect of Antibiotic Use Within First 48 Hours of Life on the Preterm Infant Microbiome: A Randomized Clinical Trial. JAMA Pediatr. 2021 03 01; 175(3):303-305.
PMID: 33196773
Necrotizing enterocolitis intestinal barrier function protection by antenatal dexamethasone and surfactant-D in a rat model.
Lu L, Lu J, Yu Y, Claud E. Necrotizing enterocolitis intestinal barrier function protection by antenatal dexamethasone and surfactant-D in a rat model. Pediatr Res. 2021 10; 90(4):768-775.
PMID: 33469185
Bacteroidota and Lachnospiraceae integration into the gut microbiome at key time points in early life are linked to infant neurodevelopment.
Oliphant K, Ali M, D'Souza M, Hughes PD, Sulakhe D, Wang AZ, Xie B, Yeasin R, Msall ME, Andrews B, Claud EC. Bacteroidota and Lachnospiraceae integration into the gut microbiome at key time points in early life are linked to infant neurodevelopment. Gut Microbes. 2021 Jan-Dec; 13(1):1997560.
PMID: 34839801
Childhood Development and the Microbiome-The Intestinal Microbiota in Maintenance of Health and Development of Disease During Childhood Development.
Ronan V, Yeasin R, Claud EC. Childhood Development and the Microbiome-The Intestinal Microbiota in Maintenance of Health and Development of Disease During Childhood Development. Gastroenterology. 2021 01; 160(2):495-506.
PMID: 33307032
The Inaugural Peter Huttenlocher Award for Scholarly Excellence
The University of Chicago
2018
Elected to American Pediatrics Society
2014
The George M Eisenberg Foundation for Charities Excellence in Pediatrics Award
The University of Chicago
2014
March of Dimes Basil O’Connor Starter Scholar Award
2009 - 2011
Elected to Society for Pediatric Research
2005
Frederick M. Kenny Award in Pediatric Research
1997
Alpha Omega Alpha
1989
Honors Program in Medical Education
Northwestern University
1984 - 1990