Our Faculty

Eugene B. Chang, MD

The focus of my group is on the study of the intestinal microbes and how they interact with the host. This relationship is fundamental to our health and, when perturbed, the consequences can be catastrophic. In this regard, the emergence of “new age” disorders like diabetes, obesity, metabolic syndrome, cancer and autoimmune disorders over the past century may be related to large shifts in the composite human microbiome caused by changes in the environment and life styles. In genetically susceptible individuals, these factors can potentially trigger events that disturb immune and metabolic homeostasis, initiating the development of disease. Our efforts are therefore directed towards gaining a better understanding of what factors are involved in the selection and assembly of intestinal microbes, and how they can be used to reshape the enteric microbiome to prevent and treat disease. We employ cutting edge approaches that include cultivation-dependent and –independent technologies for microbial analysis, genetically modified and gnotobiotic mouse models, metabolic and functional measurements, and advanced bioinformatic tools to investigate both the host and the microbiome.



For more information, visit my laboratory website: http://changlab.uchicago.edu/

Microbial Colonization of Germ-Free Mice Restores Neointimal Hyperplasia Development After Arterial Injury.
Chen EB, Shapiro KE, Wun K, Kuntz T, Theriault BR, Nooromid MJ, Leone VA, Harris KG, Jiang Q, Spedale M, Xiong L, Gilbert JA, Chang EB, Ho KJ. Microbial Colonization of Germ-Free Mice Restores Neointimal Hyperplasia Development After Arterial Injury. J Am Heart Assoc. 2020 Mar 03; 9(5):e013496.
PMID: 32089055

Microbiota composition modulates inflammation and neointimal hyperplasia after arterial angioplasty.
Cason CA, Kuntz TM, Chen EB, Wun K, Nooromid MJ, Xiong L, Gottel NR, Harris KG, Morton TC, Avram MJ, Chang EB, Gilbert JA, Ho KJ. Microbiota composition modulates inflammation and neointimal hyperplasia after arterial angioplasty. J Vasc Surg. 2020 Feb 04.
PMID: 32035769

TGR5 signaling mitigates parenteral nutrition-associated liver disease.
Willis KA, Gomes CK, Rao P, Micic D, Moran ER, Stephenson E, Puchowicz M, Al Abdallah Q, Mims TS, Gosain A, Yin D, Talati AJ, Chang EB, Han JC, Pierre JF. TGR5 signaling mitigates parenteral nutrition-associated liver disease. Am J Physiol Gastrointest Liver Physiol. 2020 Feb 01; 318(2):G322-G335.
PMID: 31905022

Aerobic capacity attainment and reasons for cardiopulmonary exercise test termination in people with cancer: a descriptive, retrospective analysis from a single laboratory.
Santa Mina D, Au D, Papadopoulos E, O'Neill M, Diniz C, Dolan L, Lipton J, Chang E, Jones JM. Aerobic capacity attainment and reasons for cardiopulmonary exercise test termination in people with cancer: a descriptive, retrospective analysis from a single laboratory. Support Care Cancer. 2020 Jan 04.
PMID: 31900621

Intersection of the Gut Microbiome and Circadian Rhythms in Metabolism.
Frazier K, Chang EB. Intersection of the Gut Microbiome and Circadian Rhythms in Metabolism. Trends Endocrinol Metab. 2020 Jan; 31(1):25-36.
PMID: 31677970

Western Diet Promotes Intestinal Colonization by Collagenolytic Microbes and Promotes Tumor Formation After Colorectal Surgery.
Gaines S, van Praagh JB, Williamson AJ, Jacobson RA, Hyoju S, Zaborin A, Mao J, Koo HY, Alpert L, Bissonnette M, Weichselbaum R, Gilbert J, Chang E, Hyman N, Zaborina O, Shogan BD, Alverdy JC. Western Diet Promotes Intestinal Colonization by Collagenolytic Microbes and Promotes Tumor Formation After Colorectal Surgery. Gastroenterology. 2019 Oct 23.
PMID: 31655031

Regional Diversity of the Gastrointestinal Microbiome.
Martinez-Guryn K, Leone V, Chang EB. Regional Diversity of the Gastrointestinal Microbiome. Cell Host Microbe. 2019 09 11; 26(3):314-324.
PMID: 31513770

Development, implementation, and effects of a cancer center's exercise-oncology program.
Santa Mina D, Au D, Auger LE, Alibhai SMH, Matthew AG, Sabiston CM, Oh P, Ritvo PG, Chang EB, Jones JM. Development, implementation, and effects of a cancer center's exercise-oncology program. Cancer. 2019 Oct 01; 125(19):3437-3447.
PMID: 31206630

Responsible stewardship for communicating microbiome research to the press and public.
Shan Y, Segre JA, Chang EB. Responsible stewardship for communicating microbiome research to the press and public. Nat Med. 2019 06; 25(6):872-874.
PMID: 31133694

Challenges in IBD Research: Preclinical Human IBD Mechanisms.
Pizarro TT, Stappenbeck TS, Rieder F, Rosen MJ, Colombel JF, Donowitz M, Towne J, Mazmanian SK, Faith JJ, Hodin RA, Garrett WS, Fichera A, Poritz LS, Cortes CJ, Shtraizent N, Honig G, Snapper SB, Hurtado-Lorenzo A, Salzman NH, Chang EB. Challenges in IBD Research: Preclinical Human IBD Mechanisms. Inflamm Bowel Dis. 2019 05 16; 25(Suppl 2):S5-S12.
PMID: 31095706

View All Publications

Takeda Distinguished Scientist Award
Takeda, Inc.
2014

National Diabetes and Digestive and Kidney Disease Advisory Council
National Institutes of Health
2013 - 2017

AGA Outstanding Mentorship award
American Gastroenterological Association
2013

AGA Academy of Educators
American Gastroenterological Association
2013

NIH Merit Award
National Institutes of Health
2008 - 2018