The focus of my group is on the study of the intestinal microbes and how they interact with the host. This relationship is fundamental to our health and, when perturbed, the consequences can be catastrophic. In this regard, the emergence of “new age” disorders like diabetes, obesity, metabolic syndrome, cancer and autoimmune disorders over the past century may be related to large shifts in the composite human microbiome caused by changes in the environment and life styles. In genetically susceptible individuals, these factors can potentially trigger events that disturb immune and metabolic homeostasis, initiating the development of disease. Our efforts are therefore directed towards gaining a better understanding of what factors are involved in the selection and assembly of intestinal microbes, and how they can be used to reshape the enteric microbiome to prevent and treat disease. We employ cutting edge approaches that include cultivation-dependent and –independent technologies for microbial analysis, genetically modified and gnotobiotic mouse models, metabolic and functional measurements, and advanced bioinformatic tools to investigate both the host and the microbiome.
For more information, visit my laboratory website: http://changlab.uchicago.edu/
A metagenome-assembled genome inventory for children reveals early-life gut bacteriome and virome dynamics.
A metagenome-assembled genome inventory for children reveals early-life gut bacteriome and virome dynamics. Cell Host Microbe. 2024 Dec 11; 32(12):2212-2230.e8.
PMID: 39591974
Correction: Sodium oligomannate alters gut microbiota, reduces cerebral amyloidosis and reactive microglia in a sex-specific manner.
Correction: Sodium oligomannate alters gut microbiota, reduces cerebral amyloidosis and reactive microglia in a sex-specific manner. Mol Neurodegener. 2024 Oct 10; 19(1):70.
PMID: 39390529
Noninvasive, microbiome-based diagnosis of inflammatory bowel disease.
Noninvasive, microbiome-based diagnosis of inflammatory bowel disease. Nat Med. 2024 Dec; 30(12):3555-3567.
PMID: 39367251
Effects of Antihypertensive Therapy During Pregnancy on Postpartum Blood Pressure Control.
Effects of Antihypertensive Therapy During Pregnancy on Postpartum Blood Pressure Control. Obstet Gynecol. 2024 Oct 01; 144(4):536-542.
PMID: 39265175
Microbiota-dependent early-life programming of gastrointestinal motility.
Microbiota-dependent early-life programming of gastrointestinal motility. iScience. 2024 Oct 18; 27(10):110895.
PMID: 39351201
A Comparative Analysis of Clinical Symptoms and Modified Pouchitis Disease Activity Index Among Endoscopic Phenotypes of the J Pouch in Patients With Inflammatory Bowel Disease.
A Comparative Analysis of Clinical Symptoms and Modified Pouchitis Disease Activity Index Among Endoscopic Phenotypes of the J Pouch in Patients With Inflammatory Bowel Disease. Crohns Colitis 360. 2024 Jul; 6(3):otae045.
PMID: 39347443
Diet outperforms microbial transplant to drive microbiome recovery post-antibiotics.
Diet outperforms microbial transplant to drive microbiome recovery post-antibiotics. bioRxiv. 2024 Aug 01.
PMID: 39211181
Optimal Timing of Delivery for Pregnant Individuals With Mild Chronic Hypertension.
Optimal Timing of Delivery for Pregnant Individuals With Mild Chronic Hypertension. Obstet Gynecol. 2024 Sep 01; 144(3):386-393.
PMID: 39013178
Maternal gestational diabetes mellitus associates with altered gut microbiome composition and head circumference abnormalities in male offspring.
Maternal gestational diabetes mellitus associates with altered gut microbiome composition and head circumference abnormalities in male offspring. Cell Host Microbe. 2024 Jul 10; 32(7):1192-1206.e5.
PMID: 38955186
Endoscopic Normalization and Transition of J-Pouch Phenotypes Over Time in Patients With Inflammatory Bowel Disease.
Endoscopic Normalization and Transition of J-Pouch Phenotypes Over Time in Patients With Inflammatory Bowel Disease. Inflamm Bowel Dis. 2024 Jun 25.
PMID: 38916136
Takeda Distinguished Scientist Award
Takeda, Inc.
2014
National Diabetes and Digestive and Kidney Disease Advisory Council
National Institutes of Health
2013 - 2017
AGA Outstanding Mentorship award
American Gastroenterological Association
2013
AGA Academy of Educators
American Gastroenterological Association
2013
NIH Merit Award
National Institutes of Health
2008 - 2018