Our Faculty

Eugene B. Chang, MD

The focus of my group is on the study of the intestinal microbes and how they interact with the host. This relationship is fundamental to our health and, when perturbed, the consequences can be catastrophic. In this regard, the emergence of “new age” disorders like diabetes, obesity, metabolic syndrome, cancer and autoimmune disorders over the past century may be related to large shifts in the composite human microbiome caused by changes in the environment and life styles. In genetically susceptible individuals, these factors can potentially trigger events that disturb immune and metabolic homeostasis, initiating the development of disease. Our efforts are therefore directed towards gaining a better understanding of what factors are involved in the selection and assembly of intestinal microbes, and how they can be used to reshape the enteric microbiome to prevent and treat disease. We employ cutting edge approaches that include cultivation-dependent and –independent technologies for microbial analysis, genetically modified and gnotobiotic mouse models, metabolic and functional measurements, and advanced bioinformatic tools to investigate both the host and the microbiome.



For more information, visit my laboratory website: http://changlab.uchicago.edu/

Gut microbiota-driven brain Aß amyloidosis in mice requires microglia.
Dodiya HB, Lutz HL, Weigle IQ, Patel P, Michalkiewicz J, Roman-Santiago CJ, Zhang CM, Liang Y, Srinath A, Zhang X, Xia J, Olszewski M, Zhang X, Schipma MJ, Chang EB, Tanzi RE, Gilbert JA, Sisodia SS. Gut microbiota-driven brain Aß amyloidosis in mice requires microglia. J Exp Med. 2022 01 03; 219(1).
PMID: 34854884

KLF2 regulates neutrophil activation and thrombosis in cardiac hypertrophy and heart failure progression.
Tang X, Wang P, Zhang R, Watanabe I, Chang E, Vinayachandran V, Nayak L, Lapping S, Liao S, Madera A, Sweet DR, Luo J, Fei J, Jeong HW, Adams RH, Zhang T, Liao X, Jain MK. KLF2 regulates neutrophil activation and thrombosis in cardiac hypertrophy and heart failure progression. J Clin Invest. 2021 Nov 18.
PMID: 34793333

A Multifunctional Neutralizing Antibody-Conjugated Nanoparticle Inhibits and Inactivates SARS-CoV-2.
Cai X, Chen M, Prominski A, Lin Y, Ankenbruck N, Rosenberg J, Nguyen M, Shi J, Tomatsidou A, Randall G, Missiakas D, Fung J, Chang EB, Penaloza-MacMaster P, Tian B, Huang J. A Multifunctional Neutralizing Antibody-Conjugated Nanoparticle Inhibits and Inactivates SARS-CoV-2. Adv Sci (Weinh). 2021 Nov 10; e2103240.
PMID: 34761549

Chrysanthemum morifolium Flower Extract Ameliorates Obesity-Induced Inflammation and Increases the Muscle Mitochondria Content and AMPK/SIRT1 Activities in Obese Rats.
Lee Y, Lee J, Lee MS, Chang E, Kim Y. Chrysanthemum morifolium Flower Extract Ameliorates Obesity-Induced Inflammation and Increases the Muscle Mitochondria Content and AMPK/SIRT1 Activities in Obese Rats. Nutrients. 2021 Oct 19; 13(10).
PMID: 34684660

The Gut Microbiome and Inflammatory Bowel Diseases.
Shan Y, Lee M, Chang EB. The Gut Microbiome and Inflammatory Bowel Diseases. Annu Rev Med. 2021 Sep 23.
PMID: 34555295

High-Fat Diet Alters the Retinal Transcriptome in the Absence of Gut Microbiota.
Dao D, Xie B, Nadeem U, Xiao J, Movahedan A, D'Souza M, Leone V, Hariprasad SM, Chang EB, Sulakhe D, Skondra D. High-Fat Diet Alters the Retinal Transcriptome in the Absence of Gut Microbiota. Cells. 2021 08 18; 10(8).
PMID: 34440888

Gnotobiotic Operations and Assembly for Development of Germ-Free Animal Model of Laser-Induced Choroidal Neovascularization.
Movahedan A, Barba H, Spedale M, Deng N, Arvans D, Nadeem U, Leone V, Chang EB, Theriault B, Skondra D. Gnotobiotic Operations and Assembly for Development of Germ-Free Animal Model of Laser-Induced Choroidal Neovascularization. Transl Vis Sci Technol. 2021 08 02; 10(9):14.
PMID: 34388237

Epithelial wound healing in inflammatory bowel diseases: the next therapeutic frontier.
Liu CY, Cham CM, Chang EB. Epithelial wound healing in inflammatory bowel diseases: the next therapeutic frontier. Transl Res. 2021 10; 236:35-51.
PMID: 34126257

Early-Life Microbial Restitution Reduces Colitis Risk Promoted by Antibiotic-Induced Gut Dysbiosis in Interleukin 10-/- Mice.
Miyoshi J, Miyoshi S, Delmont TO, Cham C, Lee STM, Sakatani A, Yang K, Shan Y, Kennedy M, Kiefl E, Yousef M, Crosson S, Sogin M, Antonopoulos DA, Eren AM, Leone V, Chang EB. Early-Life Microbial Restitution Reduces Colitis Risk Promoted by Antibiotic-Induced Gut Dysbiosis in Interleukin 10-/- Mice. Gastroenterology. 2021 09; 161(3):940-952.e15.
PMID: 34111469

Gut microbiota as a transducer of dietary cues to regulate host circadian rhythms and metabolism.
Choi H, Rao MC, Chang EB. Gut microbiota as a transducer of dietary cues to regulate host circadian rhythms and metabolism. Nat Rev Gastroenterol Hepatol. 2021 10; 18(10):679-689.
PMID: 34002082

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Takeda Distinguished Scientist Award
Takeda, Inc.
2014

National Diabetes and Digestive and Kidney Disease Advisory Council
National Institutes of Health
2013 - 2017

AGA Outstanding Mentorship award
American Gastroenterological Association
2013

AGA Academy of Educators
American Gastroenterological Association
2013

NIH Merit Award
National Institutes of Health
2008 - 2018