The focus of my group is on the study of the intestinal microbes and how they interact with the host. This relationship is fundamental to our health and, when perturbed, the consequences can be catastrophic. In this regard, the emergence of “new age” disorders like diabetes, obesity, metabolic syndrome, cancer and autoimmune disorders over the past century may be related to large shifts in the composite human microbiome caused by changes in the environment and life styles. In genetically susceptible individuals, these factors can potentially trigger events that disturb immune and metabolic homeostasis, initiating the development of disease. Our efforts are therefore directed towards gaining a better understanding of what factors are involved in the selection and assembly of intestinal microbes, and how they can be used to reshape the enteric microbiome to prevent and treat disease. We employ cutting edge approaches that include cultivation-dependent and –independent technologies for microbial analysis, genetically modified and gnotobiotic mouse models, metabolic and functional measurements, and advanced bioinformatic tools to investigate both the host and the microbiome.
For more information, visit my laboratory website: http://changlab.uchicago.edu/
Imbalanced gut microbiota predicts and drives the progression of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis in a fast-food diet mouse model.
Imbalanced gut microbiota predicts and drives the progression of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis in a fast-food diet mouse model. bioRxiv. 2023 Jan 09.
PMID: 36712061
Gut microbiota modulates bleomycin-induced acute lung injury response in mice.
Gut microbiota modulates bleomycin-induced acute lung injury response in mice. Respir Res. 2022 Dec 10; 23(1):337.
PMID: 36496380
Effects of Vitamin D Supplementation on Adipose Tissue Inflammation and NF-?B/AMPK Activation in Obese Mice Fed a High-Fat Diet.
Effects of Vitamin D Supplementation on Adipose Tissue Inflammation and NF-?B/AMPK Activation in Obese Mice Fed a High-Fat Diet. Int J Mol Sci. 2022 Sep 18; 23(18).
PMID: 36142842
Outcomes of Ileoanal Pouch Anastomosis in Pediatric Ulcerative Colitis Are Worse in the Modern Era: A Time Trend Analysis Outcomes Following Ileal Pouch-Anal Anastomosis in Pediatric Ulcerative Colitis.
Outcomes of Ileoanal Pouch Anastomosis in Pediatric Ulcerative Colitis Are Worse in the Modern Era: A Time Trend Analysis Outcomes Following Ileal Pouch-Anal Anastomosis in Pediatric Ulcerative Colitis. Inflamm Bowel Dis. 2022 09 01; 28(9):1386-1394.
PMID: 35040964
Absence of Gut Microbiota Is Associated with RPE/Choroid Transcriptomic Changes Related to Age-Related Macular Degeneration Pathobiology and Decreased Choroidal Neovascularization.
Absence of Gut Microbiota Is Associated with RPE/Choroid Transcriptomic Changes Related to Age-Related Macular Degeneration Pathobiology and Decreased Choroidal Neovascularization. Int J Mol Sci. 2022 Aug 26; 23(17).
PMID: 36077073
Atypical behavioral and thermoregulatory circadian rhythms in mice lacking a microbiome.
Atypical behavioral and thermoregulatory circadian rhythms in mice lacking a microbiome. Sci Rep. 2022 08 25; 12(1):14491.
PMID: 36008471
High-Fat Diet Alters the Retinal Pigment Epithelium and Choroidal Transcriptome in the Absence of Gut Microbiota.
High-Fat Diet Alters the Retinal Pigment Epithelium and Choroidal Transcriptome in the Absence of Gut Microbiota. Cells. 2022 06 30; 11(13).
PMID: 35805160
High-fat diet disrupts REG3? and gut microbial rhythms promoting metabolic dysfunction.
High-fat diet disrupts REG3? and gut microbial rhythms promoting metabolic dysfunction. Cell Host Microbe. 2022 06 08; 30(6):809-823.e6.
PMID: 35439436
The regulatory role of N<sup>6</sup> -methyladenosine modification in the interaction between host and microbes.
The regulatory role of N<sup>6</sup> -methyladenosine modification in the interaction between host and microbes. Wiley Interdiscip Rev RNA. 2022 11; 13(6):e1725.
PMID: 35301791
Histopathology of Colectomy Specimens Predicts Endoscopic Pouch Phenotype in Patients with Ulcerative Colitis.
Histopathology of Colectomy Specimens Predicts Endoscopic Pouch Phenotype in Patients with Ulcerative Colitis. Dig Dis Sci. 2022 08; 67(8):4020-4031.
PMID: 35288827
Takeda Distinguished Scientist Award
Takeda, Inc.
2014
National Diabetes and Digestive and Kidney Disease Advisory Council
National Institutes of Health
2013 - 2017
AGA Outstanding Mentorship award
American Gastroenterological Association
2013
AGA Academy of Educators
American Gastroenterological Association
2013
NIH Merit Award
National Institutes of Health
2008 - 2018