The focus of my group is on the study of the intestinal microbes and how they interact with the host. This relationship is fundamental to our health and, when perturbed, the consequences can be catastrophic. In this regard, the emergence of “new age” disorders like diabetes, obesity, metabolic syndrome, cancer and autoimmune disorders over the past century may be related to large shifts in the composite human microbiome caused by changes in the environment and life styles. In genetically susceptible individuals, these factors can potentially trigger events that disturb immune and metabolic homeostasis, initiating the development of disease. Our efforts are therefore directed towards gaining a better understanding of what factors are involved in the selection and assembly of intestinal microbes, and how they can be used to reshape the enteric microbiome to prevent and treat disease. We employ cutting edge approaches that include cultivation-dependent and –independent technologies for microbial analysis, genetically modified and gnotobiotic mouse models, metabolic and functional measurements, and advanced bioinformatic tools to investigate both the host and the microbiome.
For more information, visit my laboratory website: http://changlab.uchicago.edu/
Optimal Timing of Delivery for Pregnant Individuals With Mild Chronic Hypertension.
Optimal Timing of Delivery for Pregnant Individuals With Mild Chronic Hypertension. Obstet Gynecol. 2024 Jul 17.
PMID: 39013178
Maternal gestational diabetes mellitus associates with altered gut microbiome composition and head circumference abnormalities in male offspring.
Maternal gestational diabetes mellitus associates with altered gut microbiome composition and head circumference abnormalities in male offspring. Cell Host Microbe. 2024 Jul 10; 32(7):1192-1206.e5.
PMID: 38955186
Endoscopic Normalization and Transition of J-Pouch Phenotypes Over Time in Patients With Inflammatory Bowel Disease.
Endoscopic Normalization and Transition of J-Pouch Phenotypes Over Time in Patients With Inflammatory Bowel Disease. Inflamm Bowel Dis. 2024 Jun 25.
PMID: 38916136
Pregnancy Outcomes of Nifedipine Compared With Labetalol for Oral Treatment of Mild Chronic Hypertension.
Pregnancy Outcomes of Nifedipine Compared With Labetalol for Oral Treatment of Mild Chronic Hypertension. Obstet Gynecol. 2024 Jul 01; 144(1):126-134.
PMID: 38949541
Mean Arterial Pressure and Neonatal Outcomes in Pregnancies Complicated by Mild Chronic Hypertension.
Mean Arterial Pressure and Neonatal Outcomes in Pregnancies Complicated by Mild Chronic Hypertension. Obstet Gynecol. 2024 Jul 01; 144(1):101-108.
PMID: 38781591
Antibiotic-Induced Gut Microbiota Dysbiosis Modulates Host Transcriptome and m6A Epitranscriptome via Bile Acid Metabolism.
Antibiotic-Induced Gut Microbiota Dysbiosis Modulates Host Transcriptome and m6A Epitranscriptome via Bile Acid Metabolism. Adv Sci (Weinh). 2024 May 07; e2307981.
PMID: 38713722
A cryptic plasmid is among the most numerous genetic elements in the human gut.
A cryptic plasmid is among the most numerous genetic elements in the human gut. Cell. 2024 Feb 29; 187(5):1206-1222.e16.
PMID: 38428395
Sodium oligomannate alters gut microbiota, reduces cerebral amyloidosis and reactive microglia in a sex-specific manner.
Sodium oligomannate alters gut microbiota, reduces cerebral amyloidosis and reactive microglia in a sex-specific manner. Mol Neurodegener. 2024 Feb 17; 19(1):18.
PMID: 38365827
A novel conjugative transposon carrying an autonomously amplified plasmid.
A novel conjugative transposon carrying an autonomously amplified plasmid. mBio. 2024 Feb 14; 15(2):e0278723.
PMID: 38259081
Microbially catalyzed conjugation of GABA and tyramine to bile acids.
Microbially catalyzed conjugation of GABA and tyramine to bile acids. J Bacteriol. 2024 01 25; 206(1):e0042623.
PMID: 38174933
Takeda Distinguished Scientist Award
Takeda, Inc.
2014
National Diabetes and Digestive and Kidney Disease Advisory Council
National Institutes of Health
2013 - 2017
AGA Outstanding Mentorship award
American Gastroenterological Association
2013
AGA Academy of Educators
American Gastroenterological Association
2013
NIH Merit Award
National Institutes of Health
2008 - 2018