Our Faculty

Evgeny G Izumchenko, PhD

Dr. Izumchenko received his Bachelor of Laboratory Medicine (B.Med.Lab.) and Master degree in Clinical Biochemistry (M.Med.Sc.) from Ben-Gurion University (BGU) School of Medicine, Israel, where he graduated summa cum laude from the Faculty of Health Sciences. He received his Ph.D. from Ben-Gurion University via the BGU/Fox Chase Cancer Center Partnership Graduate Research Program. He has performed thesis work in the laboratory of Dr. Erica Golemis, an internationally recognized cancer biologist, and his studies provided some of the earliest insights on the role of NEDD9 in the early stages of cancer development. He completed his first postdoctoral training with Dr. Kevin Brown and Dr. Stratford May at the University of Florida, with an NIH postdoctoral fellowship supporting his research. His studies described a novel mechanism by which dysregulation of genomic stability drives cancer development. Dr. Izumchenko joined the lab of Dr. David Sidransky at Johns Hopkins University in 2012, where he carried out seminal work in defining the clonal evolution and heterogeneity in several solid tumor types, at both the genetic and epigenetic levels. Based on his record of research accomplishments, he was invited to join the Department of Otolaryngology as an Instructor in 2016, and subsequently was promoted to the rank of Assistant Professor in May, 2017. Dr. Izumchenko joined the Department of Medicine at the University of Chicago in 2019. His research focus is on understanding the complex interplay between the genetic and epigenetic alterations in carcinogenesis and disease progression, and on exploiting this understanding for developing novel biomarkers for diagnosis and risk stratification as well as in identifying targets for therapeutic intervention. Specifically, he is interested in defining the drivers underlying the premalignant progression and early immune evasion. Dr. Izumchenko has focused his research on cancers of upper aerodigestive tract, which is a very challenging area of oncology. He is actively engaged in partnering with researchers and oncologists in academia and pharmaceutical industry worldwide, to advance discovery of biomarkers for early cancer detection and risk assessment, personalized therapy, and novel anti-cancer interventions.

Johns Hopkins University
Baltimore, MD
Postdoctoral Fellow - Cancer Research
2016

University of Florida, Department of Biochemistry and Molecular Biology
Gainesville, FL
Postdoctoral Fellow - Cancer Research
2012

Ben-Gurion University, School of Medicine
Israel
Ph.D. - Cancer Research
2010

Ben-Gurion University, Dept of Clinical Biochemistry and Pharmacology
Israel
M.Med.Sc. - Clinical Biochemistry and Pharmacology
2005

Identification of Therapeutic Targets for Amyotrophic Lateral Sclerosis Using PandaOmics - An AI-Enabled Biological Target Discovery Platform.
Pun FW, Liu BHM, Long X, Leung HW, Leung GHD, Mewborne QT, Gao J, Shneyderman A, Ozerov IV, Wang J, Ren F, Aliper A, Bischof E, Izumchenko E, Guan X, Zhang K, Lu B, Rothstein JD, Cudkowicz ME, Zhavoronkov A. Identification of Therapeutic Targets for Amyotrophic Lateral Sclerosis Using PandaOmics - An AI-Enabled Biological Target Discovery Platform. Front Aging Neurosci. 2022; 14:914017.
PMID: 35837482

The role of NSD1, NSD2, and NSD3 histone methyltransferases in solid tumors.
Topchu I, Pangeni RP, Bychkov I, Miller SA, Izumchenko E, Yu J, Golemis E, Karanicolas J, Boumber Y. The role of NSD1, NSD2, and NSD3 histone methyltransferases in solid tumors. Cell Mol Life Sci. 2022 May 09; 79(6):285.
PMID: 35532818

Development and Validation of a Decision Analytical Model for Posttreatment Surveillance for Patients With Oropharyngeal Carcinoma.
Nair V, Auger S, Kochanny S, Howard FM, Ginat D, Pasternak-Wise O, Juloori A, Koshy M, Izumchenko E, Agrawal N, Rosenberg A, Vokes EE, Skandari MR, Pearson AT. Development and Validation of a Decision Analytical Model for Posttreatment Surveillance for Patients With Oropharyngeal Carcinoma. JAMA Netw Open. 2022 04 01; 5(4):e227240.
PMID: 35416988

Hallmarks of aging-based dual-purpose disease and age-associated targets predicted using PandaOmics AI-powered discovery engine.
Pun FW, Leung GHD, Leung HW, Liu BHM, Long X, Ozerov IV, Wang J, Ren F, Aliper A, Izumchenko E, Moskalev A, de Magalhães JP, Zhavoronkov A. Hallmarks of aging-based dual-purpose disease and age-associated targets predicted using PandaOmics AI-powered discovery engine. Aging (Albany NY). 2022 03 29; 14(6):2475-2506.
PMID: 35347083

Molecular drivers of oral cavity squamous cell carcinoma in non-smoking and non-drinking patients: what do we know so far?
Uddin S, Singh A, Mishra V, Agrawal N, Gooi Z, Izumchenko E. Molecular drivers of oral cavity squamous cell carcinoma in non-smoking and non-drinking patients: what do we know so far? Oncol Rev. 2022 Feb 22; 16(1):549.
PMID: 35340886

Prospective study evaluating dynamic changes of cell-free HPV DNA in locoregional viral-associated oropharyngeal cancer treated with induction chemotherapy and response-adaptive treatment.
Rosenberg AJ, Izumchenko E, Pearson A, Gooi Z, Blair E, Karrison T, Juloori A, Ginat D, Cipriani N, Lingen M, Sloane H, Edelstein DL, Keyser K, Fredebohm J, Holtrup F, Jones FS, Haraf D, Agrawal N, Vokes EE. Prospective study evaluating dynamic changes of cell-free HPV DNA in locoregional viral-associated oropharyngeal cancer treated with induction chemotherapy and response-adaptive treatment. BMC Cancer. 2022 Jan 03; 22(1):17.
PMID: 34980038

Application of liquid biopsy as multi-functional biomarkers in head and neck cancer.
Mishra V, Singh A, Chen X, Rosenberg AJ, Pearson AT, Zhavoronkov A, Savage PA, Lingen MW, Agrawal N, Izumchenko E. Application of liquid biopsy as multi-functional biomarkers in head and neck cancer. Br J Cancer. 2022 02; 126(3):361-370.
PMID: 34876674

Severe COVID-19 infection is associated with aberrant cytokine production by infected lung epithelial cells rather than by systemic immune dysfunction.
Gajewski T, Rouhani S, Trujillo J, Pyzer A, Yu J, Fessler J, Cabanov A, Higgs E, Cron K, Zha Y, Lu Y, Bloodworth J, Abasiyanik M, Okrah S, Flood B, Hatogai K, Leung M, Pezeshk A, Kozloff L, Reschke R, Strohbehn G, Chervin CS, Kumar M, Schrantz S, Madariaga ML, Beavis K, Yeo KT, Sweis R, Segal J, Tay S, Izumchenko E, Mueller J, Chen L. Severe COVID-19 infection is associated with aberrant cytokine production by infected lung epithelial cells rather than by systemic immune dysfunction. Res Sq. 2021 Nov 24.
PMID: 34845442

Risk and response adapted de-intensified treatment for HPV-associated oropharyngeal cancer: Optima paradigm expanded experience.
Rosenberg AJ, Agrawal N, Pearson A, Gooi Z, Blair E, Cursio J, Juloori A, Ginat D, Howard A, Chin J, Kochanny S, Foster C, Cipriani N, Lingen M, Izumchenko E, Seiwert TY, Haraf D, Vokes EE. Risk and response adapted de-intensified treatment for HPV-associated oropharyngeal cancer: Optima paradigm expanded experience. Oral Oncol. 2021 11; 122:105566.
PMID: 34662771

A robust and interpretable gene signature for predicting the lymph node status of primary T1/T2 oral cavity squamous cell carcinoma.
Ghantous Y, Omar M, Broner EC, Agrawal N, Pearson AT, Rosenberg AJ, Mishra V, Singh A, El-Naaj IA, Savage PA, Sidransky D, Marchionni L, Izumchenko E. A robust and interpretable gene signature for predicting the lymph node status of primary T1/T2 oral cavity squamous cell carcinoma. Int J Cancer. 2022 02 01; 150(3):450-460.
PMID: 34569064

View All Publications

Adenoid Cystic Carcinoma Research Foundation (ACCRF) Award
Adenoid Cystic Carcinoma Research Foundation
2020

The U.S.-Israel Binational Science Foundation Award
The U.S.-Israel Binational Science Foundation
2020

University of Chicago Comprehensive Cancer Center Pilot Project Award
University of Chicago
2020

Janet D. Rowley Discovery Award
University of Chicago
2019

2019 Cancer Spotlights Award
University of Chicago
2019

2017 ALCF-IASLC Fellowship Award for the Early Detection of Lung Cancer
International Association for the Study of Lung Cancer (IASLC)
2017

Head and Neck Cancer Specialized Program of Research Excellence Pilot Grant Award
Johns Hopkins University
2016

Career Development Award (Head and Neck SPORE)
Johns Hopkins University
2016

The most cited manuscript in Cancer Prevention Research journal
American Association for Cancer Research (ACCR)
2015

Fox Chase Cancer Center Postdoctoral and Graduate Student Research Award
Fox Chase Cancer Center
2008

The Kreitman Foundation Ph.D. Fellowship
Ben-Gurion University
2007

Dean Award and Prize for Academic Achievements
Ben-Gurion University
2005

American Associates, Ben-Gurion University of the Negev (AABGU) research fellowship
Ben-Gurion University
2005