Our Faculty

Evgeny G Izumchenko, PhD

Dr. Izumchenko received his Bachelor of Laboratory Medicine (B.Med.Lab.) and Master degree in Clinical Biochemistry (M.Med.Sc.) from Ben-Gurion University (BGU) School of Medicine, Israel, where he graduated summa cum laude from the Faculty of Health Sciences. He received his Ph.D. from Ben-Gurion University via the BGU/Fox Chase Cancer Center Partnership Graduate Research Program. He has performed thesis work in the laboratory of Dr. Erica Golemis, an internationally recognized cancer biologist, and his studies provided some of the earliest insights on the role of NEDD9 in the early stages of cancer development. He completed his first postdoctoral training with Dr. Kevin Brown and Dr. Stratford May at the University of Florida, with an NIH postdoctoral fellowship supporting his research. His studies described a novel mechanism by which dysregulation of genomic stability drives cancer development. Dr. Izumchenko joined the lab of Dr. David Sidransky at Johns Hopkins University in 2012, where he carried out seminal work in defining the clonal evolution and heterogeneity in several solid tumor types, at both the genetic and epigenetic levels. Based on his record of research accomplishments, he was invited to join the Department of Otolaryngology as an Instructor in 2016, and subsequently was promoted to the rank of Assistant Professor in May, 2017. Dr. Izumchenko joined the Department of Medicine at the University of Chicago in 2019. His research focus is on understanding the complex interplay between the genetic and epigenetic alterations in carcinogenesis and disease progression, and on exploiting this understanding for developing novel biomarkers for diagnosis and risk stratification as well as in identifying targets for therapeutic intervention. Specifically, he is interested in defining the drivers underlying the premalignant progression and early immune evasion. Dr. Izumchenko has focused his research on cancers of upper aerodigestive tract, which is a very challenging area of oncology. He is actively engaged in partnering with researchers and oncologists in academia and pharmaceutical industry worldwide, to advance discovery of biomarkers for early cancer detection and risk assessment, personalized therapy, and novel anti-cancer interventions.

Johns Hopkins University
Baltimore, MD
Postdoctoral Fellow - Cancer Research
2016

University of Florida, Department of Biochemistry and Molecular Biology
Gainesville, FL
Postdoctoral Fellow - Cancer Research
2012

Ben-Gurion University, School of Medicine
Israel
Ph.D. - Cancer Research
2010

Ben-Gurion University, Dept of Clinical Biochemistry and Pharmacology
Israel
M.Med.Sc. - Clinical Biochemistry and Pharmacology
2005

Sensitive detection and quantification of SARS-CoV-2 in saliva.
Abasiyanik MF, Flood B, Lin J, Ozcan S, Rouhani SJ, Pyzer A, Trujillo J, Zhen C, Wu P, Jumic S, Wang A, Gajewski TF, Wang P, Hartley M, Ameti B, Niemiec R, Fernando M, Mishra V, Savage P, Aydogan B, Bethel C, Matushek S, Beavis KG, Agrawal N, Segal J, Tay S, Izumchenko E. Sensitive detection and quantification of SARS-CoV-2 in saliva. Sci Rep. 2021 06 14; 11(1):12425.
PMID: 34127708

Neoantigen evolution in head and neck cancer progression: where do we go from here?
Rosenberg AJ, Izumchenko E. Neoantigen evolution in head and neck cancer progression: where do we go from here? Oncotarget. 2021 Jun 08; 12(12):1124-1125.
PMID: 34136081

Ultrasensitive detection of tumor-specific mutations in saliva of patients with oral cavity squamous cell carcinoma.
Shanmugam A, Hariharan AK, Hasina R, Nair JR, Katragadda S, Irusappan S, Ravichandran A, Veeramachaneni V, Bettadapura R, Bhati M, Ramaswamy V, Rao VUS, Bagadia RK, Manjunath A, Manjunath NML, Solomon MC, Maji S, Bahadur U, Bettegowda C, Papadopoulos N, Lingen MW, Hariharan R, Gupta V, Agrawal N, Izumchenko E. Ultrasensitive detection of tumor-specific mutations in saliva of patients with oral cavity squamous cell carcinoma. Cancer. 2021 May 15; 127(10):1576-1589.
PMID: 33405231

Sensitive detection and quantification of SARS-CoV-2 in saliva.
Abasiyanik MF, Flood B, Lin J, Ozcan S, Rouhani SJ, Pyzer A, Trujillo J, Zhen C, Wu P, Jumic S, Wang A, Gajewski TF, Wang P, Hartley M, Ameti B, Niemiec R, Fernando M, Aydogan B, Bethel C, Matushek S, Beavis KG, Agrawal N, Segal J, Tay S, Izumchenko E. Sensitive detection and quantification of SARS-CoV-2 in saliva. medRxiv. 2020 Dec 07.
PMID: 33330880

In vitro and in vivo efficacy of the novel oral proteasome inhibitor NNU546 in multiple myeloma.
Zhou H, Lei M, Wang W, Guo M, Wang J, Zhang H, Qiao L, Feng H, Liu Z, Chen L, Hou J, Wang X, Gu C, Zhao B, Izumchenko E, Yang Y, Zhu Y. In vitro and in vivo efficacy of the novel oral proteasome inhibitor NNU546 in multiple myeloma. Aging (Albany NY). 2020 11 16; 12(22):22949-22974.
PMID: 33203800

TMPRSS2, a SARS-CoV-2 internalization protease is downregulated in head and neck cancer patients.
Sacconi A, Donzelli S, Pulito C, Ferrero S, Spinella F, Morrone A, Rigoni M, Pimpinelli F, Ensoli F, Sanguineti G, Pellini R, Agrawal N, Izumchenko E, Ciliberto G, Giannì A, Muti P, Strano S, Blandino G. TMPRSS2, a SARS-CoV-2 internalization protease is downregulated in head and neck cancer patients. J Exp Clin Cancer Res. 2020 Sep 23; 39(1):200.
PMID: 32967703

Concurrent Targeting of Potential Cancer Stem Cells Regulating Pathways Sensitizes Lung Adenocarcinoma to Standard Chemotherapy.
Shibata M, Ooki A, Inokawa Y, Sadhukhan P, Ugurlu MT, Izumchenko E, Munari E, Bogina G, Rudin CM, Gabrielson E, Singh A, Hoque MO. Concurrent Targeting of Potential Cancer Stem Cells Regulating Pathways Sensitizes Lung Adenocarcinoma to Standard Chemotherapy. Mol Cancer Ther. 2020 10; 19(10):2175-2185.
PMID: 32847981

GULP1 regulates the NRF2-KEAP1 signaling axis in urothelial carcinoma.
Hayashi M, Guida E, Inokawa Y, Goldberg R, Reis LO, Ooki A, Pilli M, Sadhukhan P, Woo J, Choi W, Izumchenko E, Gonzalez LM, Marchionni L, Zhavoronkov A, Brait M, Bivalacqua T, Baras A, Netto GJ, Koch W, Singh A, Hoque MO. GULP1 regulates the NRF2-KEAP1 signaling axis in urothelial carcinoma. Sci Signal. 2020 08 18; 13(645).
PMID: 32817372

WHSC1 monomethylates histone H1 and induces stem-cell like features in squamous cell carcinoma of the head and neck.
Saloura V, Vougiouklakis T, Bao R, Kim S, Baek S, Zewde M, Bernard B, Burkitt K, Nigam N, Izumchenko E, Dohmae N, Hamamoto R, Nakamura Y. WHSC1 monomethylates histone H1 and induces stem-cell like features in squamous cell carcinoma of the head and neck. Neoplasia. 2020 08; 22(8):283-293.
PMID: 32497898

Molecular biology of oral cavity squamous cell carcinoma.
Hsu PJ, Yan K, Shi H, Izumchenko E, Agrawal N. Molecular biology of oral cavity squamous cell carcinoma. Oral Oncol. 2020 03; 102:104552.
PMID: 31918173

View All Publications

Adenoid Cystic Carcinoma Research Foundation (ACCRF) Award
Adenoid Cystic Carcinoma Research Foundation
2020

The U.S.-Israel Binational Science Foundation Award
The U.S.-Israel Binational Science Foundation
2020

University of Chicago Comprehensive Cancer Center Pilot Project Award
University of Chicago
2020

Janet D. Rowley Discovery Award
University of Chicago
2019

2019 Cancer Spotlights Award
University of Chicago
2019

2017 ALCF-IASLC Fellowship Award for the Early Detection of Lung Cancer
International Association for the Study of Lung Cancer (IASLC)
2017

Head and Neck Cancer Specialized Program of Research Excellence Pilot Grant Award
Johns Hopkins University
2016

Career Development Award (Head and Neck SPORE)
Johns Hopkins University
2016

The most cited manuscript in Cancer Prevention Research journal
American Association for Cancer Research (ACCR)
2015

Fox Chase Cancer Center Postdoctoral and Graduate Student Research Award
Fox Chase Cancer Center
2008

The Kreitman Foundation Ph.D. Fellowship
Ben-Gurion University
2007

Dean Award and Prize for Academic Achievements
Ben-Gurion University
2005

American Associates, Ben-Gurion University of the Negev (AABGU) research fellowship
Ben-Gurion University
2005