My research integrates neurobiology and endocrinology to delineate intracellular mechanisms that customize thyroid hormone action during human brain development and function. We use human iPSCs-derived models, transgenic mice, multi-omics, in vivo, confocal fluorescence microscopy, and molecular and biochemical assays to help understand the clinical findings that abnormal maternal/perinatal thyroid hormone levels correlate with neurodevelopment.
University Miguel Hernandez
PhD - Neuroscience
2018
University Miguel Hernandez
MSc - Neuroscience
2014
University of Alicante
BS - Biology
2012
Thyroid hormone promotes fetal neurogenesis.
Thyroid hormone promotes fetal neurogenesis. JCI Insight. 2025 Oct 08; 10(19).
PMID: 40906530
Thyroid Hormone Promotes Fetal Neurogenesis.
Thyroid Hormone Promotes Fetal Neurogenesis. bioRxiv. 2025 May 14.
PMID: 40463237
Overnutrition directly impairs thyroid hormone biosynthesis and utilization, causing hypothyroidism, despite remarkable thyroidal adaptations.
Overnutrition directly impairs thyroid hormone biosynthesis and utilization, causing hypothyroidism, despite remarkable thyroidal adaptations. bioRxiv. 2025 Apr 15.
PMID: 40236234
FVB But Not B6 Mice Carrying the Thr92Ala-Dio2 Polymorphism Have Impaired Thyroid Hormonogenesis and Goiter.
FVB But Not B6 Mice Carrying the Thr92Ala-Dio2 Polymorphism Have Impaired Thyroid Hormonogenesis and Goiter. Endocrinology. 2025 Mar 24; 166(5).
PMID: 40085762
Variable transduction of thyroid hormone signaling in structures of the mouse brain.
Variable transduction of thyroid hormone signaling in structures of the mouse brain. Proc Natl Acad Sci U S A. 2025 Feb 11; 122(6):e2415970122.
PMID: 39903117
Integrative Protocol for Generation of iPSC-Derived 3D Human Hepatic Organoids.
Integrative Protocol for Generation of iPSC-Derived 3D Human Hepatic Organoids. J Vis Exp. 2024 Dec 06; (214).
PMID: 39714036
Thyroid Hormone and Alzheimer Disease: Bridging Epidemiology to Mechanism.
Thyroid Hormone and Alzheimer Disease: Bridging Epidemiology to Mechanism. Endocrinology. 2024 Aug 27; 165(10).
PMID: 39276028
Mapping Thyroid Hormone Action in the Human Brain.
Mapping Thyroid Hormone Action in the Human Brain. Thyroid. 2024 07; 34(7):815-826.
PMID: 38757586
Impaired T3 uptake and action in MCT8-deficient cerebral organoids underlie Allan-Herndon-Dudley syndrome.
Impaired T3 uptake and action in MCT8-deficient cerebral organoids underlie Allan-Herndon-Dudley syndrome. JCI Insight. 2024 Feb 20; 9(7).
PMID: 38376950
Localized T3 production modifies the transcriptome and promotes the hepatocyte-like lineage in iPSC-derived hepatic organoids.
Localized T3 production modifies the transcriptome and promotes the hepatocyte-like lineage in iPSC-derived hepatic organoids. JCI Insight. 2023 12 08; 8(23).
PMID: 37856222
Emerging Group Leader Award
International Society for Neurochemistry
2025