GAURAV A. UPADHYAY, MD, FACC, FHRS is an expert in cardiac rhythm devices and Associate Professor at the University of Chicago Medicine. He is Vice Chief of Cardiology, Promotions & Appointments. He is the Director of the Pacing & Defibrillation Device Clinic and also Director of the Heart Station, overseeing ambulatory monitoring and ECGs Dr. Upadhyay’s clinical research interests include elucidating mechanisms and approaches for conduction system pacing (CSP), device optimization strategies for cardiac resynchronization therapy (CRT) in heart failure, autonomic modulation for syncope and arrhythmia, and large database analysis for catheter ablation of arrhythmias including atrial fibrillation.
Paralleling his focus on patient care, Dr. Upadhyay is an active clinical investigator. An invited national and international speaker, he has authored or delivered over 300 manuscripts, editorials, book chapters, and abstracts. He is also deeply committed to teaching, and seeks out opportunities to collaborate and engage trainees in teaching at the bedside as well as in transforming models of care.
EDUCATION
Medical Degree: University of Chicago Pritzker School of Medicine
Program in Clinical Effectiveness: Harvard T. H. Chan School of Public Health
Residency: Massachusetts General Hospital, Harvard Medical School
Cardiology Fellowship: Massachusetts General Hospital, Harvard Medical School
Electrophysiology Fellowship: Massachusetts General Hospital, Harvard Medical School
Leadless Atrial Pacing Targeting Bachmann's Bundle for Atrial Resynchronization.
Leadless Atrial Pacing Targeting Bachmann's Bundle for Atrial Resynchronization. JACC Case Rep. 2025 Jul 23; 30(20):104083.
PMID: 40377514
Cardioneural Ablation for Functional Bradycardia and Vasovagal Syncope: Outcomes From the U.S. Multicenter CNA Registry.
Cardioneural Ablation for Functional Bradycardia and Vasovagal Syncope: Outcomes From the U.S. Multicenter CNA Registry. JACC Clin Electrophysiol. 2025 Aug; 11(8):1683-1695.
PMID: 40392665
Left bundle branch area pacing compared with biventricular pacing for cardiac resynchronization therapy in patients with left ventricular ejection fraction =50%: Results from the International Collaborative LBBAP Study (I-CLAS).
Left bundle branch area pacing compared with biventricular pacing for cardiac resynchronization therapy in patients with left ventricular ejection fraction =50%: Results from the International Collaborative LBBAP Study (I-CLAS). Heart Rhythm. 2025 Aug; 22(8):2028-2037.
PMID: 40288475
Left Septal Recordings in HBP Versus LBBAP: Highlighting the Need for a Modified Nomenclature.
Left Septal Recordings in HBP Versus LBBAP: Highlighting the Need for a Modified Nomenclature. JACC Clin Electrophysiol. 2025 Jun; 11(6):1388-1392.
PMID: 40272317
Echocardiographic response from left bundle branch area pacing optimized cardiac resynchronization therapy (LOT-CRT) vs traditional CRT.
Echocardiographic response from left bundle branch area pacing optimized cardiac resynchronization therapy (LOT-CRT) vs traditional CRT. Heart Rhythm. 2025 Oct; 22(10):2616-2624.
PMID: 40254116
Association of air pollution with ventricular arrhythmias and physical activity: A natural experiment from US wildfires.
Association of air pollution with ventricular arrhythmias and physical activity: A natural experiment from US wildfires. Heart Rhythm. 2025 Aug; 22(8):e374-e379.
PMID: 40107401
Performance of an active fixation stylet-driven lead in left bundle branch area pacing: Results from INSIGHT-LBBA.
Performance of an active fixation stylet-driven lead in left bundle branch area pacing: Results from INSIGHT-LBBA. Heart Rhythm. 2025 Aug; 22(8):2047-2054.
PMID: 39914662
Importance of Prolonged QRS Duration in Detecting Complete Conduction Block-Reply.
Importance of Prolonged QRS Duration in Detecting Complete Conduction Block-Reply. JAMA Cardiol. 2024 Dec 01; 9(12):1172.
PMID: 39292492
Comparing outcomes after pulmonary vein isolation in patients with systolic and diastolic heart failure.
Comparing outcomes after pulmonary vein isolation in patients with systolic and diastolic heart failure. Heart Rhythm O2. 2024 Aug; 5(8):529-537.
PMID: 39263616
Procedural and Intermediate-term Results of the Electroanatomical-guided Cardioneuroablation for the Treatment of Supra-Hisian Second- or Advanced-degree Atrioventricular Block: the PIRECNA multicentre registry.
Procedural and Intermediate-term Results of the Electroanatomical-guided Cardioneuroablation for the Treatment of Supra-Hisian Second- or Advanced-degree Atrioventricular Block: the PIRECNA multicentre registry. Europace. 2024 Jul 02; 26(7).
PMID: 38954426