The de Wit laboratory investigates the subjective, behavioral and physiological effects of drugs of abuse in healthy human volunteers. Some studies are designed to identify individual differences and risk factors for excessive use, and others to determine the effects of drugs on mood, psychomotor and cognitive performance, and brain activity. Another major interest is the study of conditioned drug effects, or cues, that influence future drug use.
Concordia University
Montreal Canada
PhD - Experimental Psychology
1981
University of Calgary
Calgary Canada
BA - Psychology
1969
Development of the MDMA-Assisted Psychotherapy Side Effects Tool (M-SET): a Delphi study.
Development of the MDMA-Assisted Psychotherapy Side Effects Tool (M-SET): a Delphi study. BMJ Open. 2026 May 11; 16(5):e105630.
PMID: 42114863
Acute and delayed effects of THC on memories of stress in healthy adults.
Acute and delayed effects of THC on memories of stress in healthy adults. Psychopharmacology (Berl). 2026 Apr 15.
PMID: 41984202
Co-Use of Alcohol and Cannabis: How Are They Related?
Co-Use of Alcohol and Cannabis: How Are They Related? Am J Psychiatry. 2026 Feb 01; 183(2):96-97.
PMID: 41620813
Reward-related neural activity after low doses of LSD in participants with depressed mood.
Reward-related neural activity after low doses of LSD in participants with depressed mood. J Psychopharmacol. 2026 Sep; 40(9):1368-1380.
PMID: 41529826
Effects of Psilocybin on Religious and Spiritual Attitudes and Behaviors in Clergy from Various Major World Religions, by Griffiths et al.
Effects of Psilocybin on Religious and Spiritual Attitudes and Behaviors in Clergy from Various Major World Religions, by Griffiths et al. Psychedelic Med (New Rochelle). 2025 Dec; 3(4):211-212.
PMID: 41869008
m-DASC: Measuring Subjective Effects of Very Low Doses of Psychedelic Drugs.
m-DASC: Measuring Subjective Effects of Very Low Doses of Psychedelic Drugs. Psychedelic Med (New Rochelle). 2026 Mar; 4(1):81-88.
PMID: 42130780
Methamphetamine Modulates Functional Connectivity Signatures of Sustained Attention and Arousal.
Methamphetamine Modulates Functional Connectivity Signatures of Sustained Attention and Arousal. Biol Psychiatry Cogn Neurosci Neuroimaging. 2026 Aug; 11(8):976-986.
PMID: 41297882
The effect of methamphetamine and 3,4-methylenedioxymethamphetamine on peripheral endocannabinoid concentrations: a study in healthy adults.
The effect of methamphetamine and 3,4-methylenedioxymethamphetamine on peripheral endocannabinoid concentrations: a study in healthy adults. Psychopharmacology (Berl). 2026 Feb; 243(2):413-426.
PMID: 41051544
The empathogen 3,4-methylenedioxymethamphetamine, but not methamphetamine, increases feelings of global trust.
The empathogen 3,4-methylenedioxymethamphetamine, but not methamphetamine, increases feelings of global trust. J Psychopharmacol. 2026 Sep; 40(9):1361-1367.
PMID: 40958371
?9-Tetrahydrocannabinol Alters Limbic and Frontal Functional Brain Connectomes Among Young Adult Cannabis Users.
?9-Tetrahydrocannabinol Alters Limbic and Frontal Functional Brain Connectomes Among Young Adult Cannabis Users. Biol Psychiatry Cogn Neurosci Neuroimaging. 2026 May; 11(5):580-589.
PMID: 40957507
Lifetime Achievement Award
Research Society on Alcoholism
2020
John F. Lemieux Medal for Distinguished Alumni
Concordia University, Montreal
2020
Distinguished Achievement Award
European Behavioural Pharmacology Society
2019
Distinguished Lecturer, Elizabeth Fitzgerald Sporar Endowment Distinguished Initiatives in Addiction
University of Texas
2016
Marian W. Fischman Memorial Lectureship Award
College of Problems on Drug Dependence
2009
Solvay Award for Outstanding Basic Psychopharmacological Research in Affective Disorders
American Psychological Association
1999