Dr. Lin leads a research laboratory focused on the function, regulation, and therapeutic targeting of enzymes that control protein post-translational modifications (PTMs). Following the sequencing of the human genome, one of the major remaining challenges in biology and medicine is to understand the function of all proteins. Importantly, proteins are not always expressed, and even when expressed, their activity is highly regulated—often modulated by cellular stress and signaling cues. This regulation is essential to nearly all aspects of cell signaling.
Dr. Lin’s research emphasizes that to fully understand a protein’s role, it is critical to investigate how its activity is controlled. The lab, therefore, concentrates on elucidating both the function and regulation of PTM enzymes. Building on these insights, Dr. Lin’s team develops small molecule inhibitors targeting these enzymes, with the goal of advancing novel therapeutics for human diseases, including cancer, autoimmune disorders, and neurodegenerative conditions.
Columbia University
New York City
PhD - bio-organic chemistry
2003
Tsinghua University
Beijing
BS - Chemistry
1998
Myristoylation of TMEM106B by NMT1/2 regulates TMEM106B trafficking and turnover.
Myristoylation of TMEM106B by NMT1/2 regulates TMEM106B trafficking and turnover. J Biol Chem. 2025 May 30; 110322.
PMID: 40451428
SMAD2 S-palmitoylation promotes its linker region phosphorylation and TH17 cell differentiation in a mouse model of multiple sclerosis.
SMAD2 S-palmitoylation promotes its linker region phosphorylation and TH17 cell differentiation in a mouse model of multiple sclerosis. Sci Signal. 2025 May 27; 18(888):eadr2008.
PMID: 40424363
SIRT2-mediated ACSS2 K271 deacetylation suppresses lipogenesis under nutrient stress.
SIRT2-mediated ACSS2 K271 deacetylation suppresses lipogenesis under nutrient stress. Elife. 2025 May 07; 13.
PMID: 40331334
Antibiotic target discovery by integrated phenotypic and activity-based profiling of electrophilic fragments.
Antibiotic target discovery by integrated phenotypic and activity-based profiling of electrophilic fragments. Cell Chem Biol. 2025 Mar 20; 32(3):434-448.e9.
PMID: 40020665
Loss of Diphthamide Increases DNA Replication Stress in Mammalian Cells by Modulating the Translation of RRM1.
Loss of Diphthamide Increases DNA Replication Stress in Mammalian Cells by Modulating the Translation of RRM1. ACS Cent Sci. 2024 Oct 23; 10(10):1835-1847.
PMID: 39463834
A Mitochondria-Targeting SIRT3 Inhibitor with Activity against Diffuse Large B Cell Lymphoma.
A Mitochondria-Targeting SIRT3 Inhibitor with Activity against Diffuse Large B Cell Lymphoma. J Med Chem. 2024 Sep 12; 67(17):15428-15437.
PMID: 39191393
MAVS Cys508 palmitoylation promotes its aggregation on the mitochondrial outer membrane and antiviral innate immunity.
MAVS Cys508 palmitoylation promotes its aggregation on the mitochondrial outer membrane and antiviral innate immunity. Proc Natl Acad Sci U S A. 2024 Aug 20; 121(34):e2403392121.
PMID: 39141356
Sirt2 inhibition improves gut epithelial barrier integrity and protects mice from colitis.
Sirt2 inhibition improves gut epithelial barrier integrity and protects mice from colitis. Proc Natl Acad Sci U S A. 2024 Apr 30; 121(18):e2319833121.
PMID: 38648480
GS-441524-Diphosphate-Ribose Derivatives as Nanomolar Binders and Fluorescence Polarization Tracers for SARS-CoV-2 and Other Viral Macrodomains.
GS-441524-Diphosphate-Ribose Derivatives as Nanomolar Binders and Fluorescence Polarization Tracers for SARS-CoV-2 and Other Viral Macrodomains. ACS Chem Biol. 2024 05 17; 19(5):1093-1105.
PMID: 38646883
NLRP3 Cys126 palmitoylation by ZDHHC7 promotes inflammasome activation.
NLRP3 Cys126 palmitoylation by ZDHHC7 promotes inflammasome activation. Cell Rep. 2024 04 23; 43(4):114070.
PMID: 38583156