Howard J. Halpern, MD, PhD, specializes in medical imaging techniques. He is an expert in very low frequency-imaging-electron paramagnetic resonance (VLF-I-EPR). This technique enables measurement of changes in oxygen content in tumor tissues--a key determinant of response to radiation therapy.
Dr. Halpern is the co-author of a textbook on free radical biology. He serves as the principal investigator for the Oversight Committee for the Laboratory Training of Radiation Oncology Residents.
University of Wisconsin
Madison, Wisconsin
PhD - High Energy Physics
1976
University of Miami
Miami, Florida
MD - Medicine
061980
Direct measurement and imaging of redox status with electron paramagnetic resonance (EPR).
Direct measurement and imaging of redox status with electron paramagnetic resonance (EPR). Antioxid Redox Signal. 2023 Jan 21.
PMID: 36680741
An iterative reconstruction algorithm without system matrix for EPR imaging.
An iterative reconstruction algorithm without system matrix for EPR imaging. J Magn Reson. 2022 11; 344:107307.
PMID: 36308904
The optimal 18F-fluoromisonidazole PET threshold to define tumor hypoxia in preclinical squamous cell carcinomas using pO2 electron paramagnetic resonance imaging as reference truth.
The optimal 18F-fluoromisonidazole PET threshold to define tumor hypoxia in preclinical squamous cell carcinomas using pO2 electron paramagnetic resonance imaging as reference truth. Eur J Nucl Med Mol Imaging. 2022 Oct; 49(12):4014-4024.
PMID: 35792927
Estimating the mechanical energy of histotripsy bubble clouds with high frame rate imaging.
Estimating the mechanical energy of histotripsy bubble clouds with high frame rate imaging. Phys Med Biol. 2021 08 05; 66(16).
PMID: 34271560
A balanced total-variation-Chambolle-Pock algorithm for EPR imaging.
A balanced total-variation-Chambolle-Pock algorithm for EPR imaging. J Magn Reson. 2021 07; 328:107009.
PMID: 34058712
Improving Tumor Hypoxia Location in 18F-Misonidazole PET with Dynamic Contrast-enhanced MRI Using Quantitative Electron Paramagnetic Resonance Partial Oxygen Pressure Images.
Improving Tumor Hypoxia Location in 18F-Misonidazole PET with Dynamic Contrast-enhanced MRI Using Quantitative Electron Paramagnetic Resonance Partial Oxygen Pressure Images. Radiol Imaging Cancer. 2021 03; 3(2):e200104.
PMID: 33817651
Development of a PET/EPRI combined imaging system for assessing tumor hypoxia.
Development of a PET/EPRI combined imaging system for assessing tumor hypoxia. J Instrum. 2021 Mar; 16(3).
PMID: 33868448
Small Animal IMRT Using 3D-Printed Compensators.
Small Animal IMRT Using 3D-Printed Compensators. Int J Radiat Oncol Biol Phys. 2021 06 01; 110(2):551-565.
PMID: 33373659
Going Low in a World Going High: The Physiologic Use of Lower Frequency Electron Paramagnetic Resonance.
Going Low in a World Going High: The Physiologic Use of Lower Frequency Electron Paramagnetic Resonance. Appl Magn Reson. 2020 Oct; 51(9-10):887-907.
PMID: 33776216
Predictors of pressure injury development in critically ill adults: A retrospective cohort study.
Sala JJ, Mayampurath A, Solmos S, Vonderheid SC, Banas M, D'Souza A, LaFond C. Predictors of pressure injury development in critically ill adults: A retrospective cohort study. Intensive Crit Care Nurs. 2021 Feb; 62:102924.
PMID: 12768596