Howard J. Halpern, MD, PhD, specializes in medical imaging techniques. He is an expert in very low frequency-imaging-electron paramagnetic resonance (VLF-I-EPR). This technique enables measurement of changes in oxygen content in tumor tissues--a key determinant of response to radiation therapy.
Dr. Halpern is the co-author of a textbook on free radical biology. He serves as the principal investigator for the Oversight Committee for the Laboratory Training of Radiation Oncology Residents.
University of Wisconsin
Madison, Wisconsin
PhD - High Energy Physics
1976
University of Miami
Miami, Florida
MD - Medicine
061980
Letting Biology Validate the EPR Imaging of Tumor pO2.
Letting Biology Validate the EPR Imaging of Tumor pO2. Adv Exp Med Biol. 2026; 1498:53-58.
PMID: 41577900
A Novel Approach to In Vivo EPR Spectroscopy for Repeatable Assessments of Oxygenation Levels in Tumors at Any Depth: Preliminary Feasibility Studies Utilizing a Multisite Oxygen Sensor Inside HDR Brachytherapy Needles.
A Novel Approach to In Vivo EPR Spectroscopy for Repeatable Assessments of Oxygenation Levels in Tumors at Any Depth: Preliminary Feasibility Studies Utilizing a Multisite Oxygen Sensor Inside HDR Brachytherapy Needles. Adv Exp Med Biol. 2026; 1498:23-35.
PMID: 41577898
A novel high order directional total variation algorithm of EPR imaging for fast scan.
A novel high order directional total variation algorithm of EPR imaging for fast scan. J Xray Sci Technol. 2026 Jan; 34(1):27-38.
PMID: 41032658
Compensator-based small animal IMRT enables conformal preclinical dose painting: application to tumor hypoxia.
Compensator-based small animal IMRT enables conformal preclinical dose painting: application to tumor hypoxia. Sci Rep. 2025 Jul 03; 15(1):23833.
PMID: 40610660
Accurate image reconstruction from reduced data in pulsed electron paramagnetic resonance imaging.
Accurate image reconstruction from reduced data in pulsed electron paramagnetic resonance imaging. J Magn Reson. 2025 Sep; 378:107920.
PMID: 40614312
Retrospective analysis and IMRT replanning of a 3D-CRT murine dose painting study for preclinical oxygen-guided radiotherapy.
Retrospective analysis and IMRT replanning of a 3D-CRT murine dose painting study for preclinical oxygen-guided radiotherapy. Sci Rep. 2025 May 22; 15(1):17755.
PMID: 40404740
Tumor Hypoxia Assessment: In Vivo 3D Oxygen Imaging Through Electron Paramagnetic Resonance.
Tumor Hypoxia Assessment: In Vivo 3D Oxygen Imaging Through Electron Paramagnetic Resonance. J Vis Exp. 2025 02 14; (216).
PMID: 40029823
An analytic, moment-based method to estimate orthopositronium lifetimes in positron annihilation lifetime spectroscopy measurements.
An analytic, moment-based method to estimate orthopositronium lifetimes in positron annihilation lifetime spectroscopy measurements. Bioalgorithms Medsyst. 2024 Sep 29; 20(Spec Issue):40-48.
PMID: 41585326
Directional TV algorithm for image reconstruction from sparse-view projections in EPR imaging.
Directional TV algorithm for image reconstruction from sparse-view projections in EPR imaging. Phys Med Biol. 2024 05 30; 69(11).
PMID: 38729205
Validation of the design of a high-sensitivity and high-resolution PET system for a preclinical PET/EPR hybrid scanner.
Validation of the design of a high-sensitivity and high-resolution PET system for a preclinical PET/EPR hybrid scanner. Nucl Instrum Methods Phys Res A. 2024 Jun; 1063.
PMID: 38736647