Our Faculty

Jason Maclean, PhD

The primary focus of our group is to apply a diversity of analytical tools, including network science approaches to corticalcircuit dynamics in order to: 1) establish the higher-order cellular and synaptic mechanisms that propagate spikes, 2) to build improved encoding and decoding models of single-trial circuit activity in behaving mammals, and 3) to compare and contrast sensory and motor areas of neocortex.

University of Manitoba
Winnipeg CANADA
PhD - Neurophysiology

Sequential addition of neuronal stem cell temporal cohorts generates a feed-forward circuit in the Drosophila larval nerve cord.
Wang YW, Wreden CC, Levy M, Meng JL, Marshall ZD, MacLean J, Heckscher E. Sequential addition of neuronal stem cell temporal cohorts generates a feed-forward circuit in the Drosophila larval nerve cord. Elife. 2022 06 20; 11.
PMID: 35723253

Validating markerless pose estimation with 3D X-ray radiography.
Moore DD, Walker JD, MacLean JN, Hatsopoulos NG. Validating markerless pose estimation with 3D X-ray radiography. J Exp Biol. 2022 05 01; 225(9).
PMID: 35466360

Chronic wireless neural population recordings with common marmosets.
Walker JD, Pirschel F, Sundiang M, Niekrasz M, MacLean JN, Hatsopoulos NG. Chronic wireless neural population recordings with common marmosets. Cell Rep. 2021 07 13; 36(2):109379.
PMID: 34260919

Cyclic transitions between higher order motifs underlie sustained asynchronous spiking in sparse recurrent networks.
Bojanek K, Zhu Y, MacLean J. Cyclic transitions between higher order motifs underlie sustained asynchronous spiking in sparse recurrent networks. PLoS Comput Biol. 2020 09; 16(9):e1007409.
PMID: 32997658

Network Analysis of Murine Cortical Dynamics Implicates Untuned Neurons in Visual Stimulus Coding.
Levy M, Sporns O, MacLean JN. Network Analysis of Murine Cortical Dynamics Implicates Untuned Neurons in Visual Stimulus Coding. Cell Rep. 2020 04 14; 31(2):107483.
PMID: 32294431

A platform for semiautomated voluntary training of common marmosets for behavioral neuroscience.
Walker JD, Pirschel F, Gidmark N, MacLean JN, Hatsopoulos NG. A platform for semiautomated voluntary training of common marmosets for behavioral neuroscience. J Neurophysiol. 2020 04 01; 123(4):1420-1426.
PMID: 32130092

Recurrent interactions can explain the variance in single trial responses.
Kotekal S, MacLean JN. Recurrent interactions can explain the variance in single trial responses. PLoS Comput Biol. 2020 01; 16(1):e1007591.
PMID: 31999693

Functional triplet motifs underlie accurate predictions of single-trial responses in populations of tuned and untuned V1 neurons.
Dechery JB, MacLean JN. Functional triplet motifs underlie accurate predictions of single-trial responses in populations of tuned and untuned V1 neurons. PLoS Comput Biol. 2018 05; 14(5):e1006153.
PMID: 29727448

Editorial: Spontaneous Activity in Sensory Systems.
Imaizumi K, Ruthazer ES, MacLean JN, Lee CC. Editorial: Spontaneous Activity in Sensory Systems. Front Neural Circuits. 2018; 12:27.
PMID: 29651239

Ensemble stacking mitigates biases in inference of synaptic connectivity.
Chambers B, Levy M, Dechery JB, MacLean JN. Ensemble stacking mitigates biases in inference of synaptic connectivity. Netw Neurosci. 2018; 2(1):60-85.
PMID: 29911678

View All Publications