The Wang Lab is focused on designing new chemical probes or drug-like molecules for the treatment of diseases and novel chemical genetic methods for drug discovery and mechanistic studies in RNA biology. We have two major research directions based on the functions of chemical probes: (1) New molecules and mechanisms that control RNA splicing and RNA degradation, and (2) Chimeric small- and macro-molecules that recruit new functions on RNAs.
Scripps Research Institute
La Jolla, CA, USA
Post-Doc - Chemical Biology
2019
Johns Hopkins University
Baltimore, MD, USA
Post-Doc - Chemical Biology
2014
University of Maryland
College Park, MD, USA
Ph.D. - Chemistry
2011
Peking University
Beijing, China
B.S. - Chemistry
2006
Chemical-guided SHAPE sequencing (cgSHAPE-seq) informs the binding site of RNA-degrading chimeras targeting SARS-CoV-2 5' untranslated region.
Chemical-guided SHAPE sequencing (cgSHAPE-seq) informs the binding site of RNA-degrading chimeras targeting SARS-CoV-2 5' untranslated region. Nat Commun. 2025 Jan 08; 16(1):483.
PMID: 39779694
Cellular Target Deconvolution of Small Molecules Using a Selection-Based Genetic Screening Platform.
Cellular Target Deconvolution of Small Molecules Using a Selection-Based Genetic Screening Platform. ACS Cent Sci. 2022 Oct 26; 8(10):1424-1434.
PMID: 36313155
Recognition of single-stranded nucleic acids by small-molecule splicing modulators.
Recognition of single-stranded nucleic acids by small-molecule splicing modulators. Nucleic Acids Res. 2021 08 20; 49(14):7870-7883.
PMID: 34283224
Parkinson’s Foundation Impact Award
Parkinson's Foundation
2023 - 2024
NIH Maximizing Investigators' Research Award (MIRA)
NIH/NIGMS
2022 - 2027