A highly skilled interventional cardiologist, Jonathan D. Paul, MD, uses minimally invasive, catheter-based techniques to diagnose and treat cardiovascular diseases. In particular, he provides care for patients with coronary artery disease, pulmonary hypertension, peripheral vascular disease, aortic disease and structural heart disease.
Dr. Paul specializes in the treatment of both acute and chronic pulmonary embolism, using a variety of advanced tools and techniques. In collaboration with other physicians across UChicago Medicine, Dr. Paul established a comprehensive venous thromboembolic diseases (VTE) program, which offers a unique approach to the diagnosis, treatment and long-term follow up for patients with deep vein thrombosis (DVT), pulmonary embolism (PE) and chronic thromboembolic pulmonary hypertension (CTEPH).
In addition to his clinical pursuits, Dr. Paul is actively researching new methods for treating acute and chronic DVT and PE, and gaining a better understanding how different therapies for acute pulmonary embolism (i.e. minimally invasive vs. conservative) affect long-term outcomes. He currently serves as principal investigator or co-investigator on a number of clinical trials.
Assessment of Catheter-Directed Thrombolysis and Histotripsy Treatment for Deep Vein Thrombosis.
Assessment of Catheter-Directed Thrombolysis and Histotripsy Treatment for Deep Vein Thrombosis. J Vasc Interv Radiol. 2025 Jun; 36(6):1051-1061.e5.
PMID: 39890017
Use of Onyx Frontier™ for intracranial stenting in stroke patients: A multicenter retrospective study.
Use of Onyx Frontier™ for intracranial stenting in stroke patients: A multicenter retrospective study. Interv Neuroradiol. 2024 Oct 21; 15910199241286922.
PMID: 39429004
Prevalence of Coronary Microvascular Dysfunction and Epicardial Spasm in Patients With Angina and Myocardial Bridge.
Prevalence of Coronary Microvascular Dysfunction and Epicardial Spasm in Patients With Angina and Myocardial Bridge. J Soc Cardiovasc Angiogr Interv. 2024 Sep; 3(9):102196.
PMID: 39575216
The association of antiplatelet agents with mortality among patients with non-COVID-19 community-acquired pneumonia: a systematic review and meta-analysis.
The association of antiplatelet agents with mortality among patients with non-COVID-19 community-acquired pneumonia: a systematic review and meta-analysis. Res Pract Thromb Haemost. 2024 Jul; 8(5):102526.
PMID: 39262648
Heparin Dose Intensity and Organ Support-Free Days in Patients Hospitalized for COVID-19.
Heparin Dose Intensity and Organ Support-Free Days in Patients Hospitalized for COVID-19. JACC Adv. 2024 Mar; 3(3):100780.
PMID: 38938844
Effects of inflammation on thrombosis and outcomes in COVID-19: secondary analysis of the ATTACC/ACTIV-4a trial.
Effects of inflammation on thrombosis and outcomes in COVID-19: secondary analysis of the ATTACC/ACTIV-4a trial. Res Pract Thromb Haemost. 2023 Oct; 7(7):102203.
PMID: 37854455
Unplanned 30-Day Readmissions after Management of Submassive and Massive Acute Pulmonary Embolism: Catheter-Directed versus Systemic Thrombolysis.
Unplanned 30-Day Readmissions after Management of Submassive and Massive Acute Pulmonary Embolism: Catheter-Directed versus Systemic Thrombolysis. J Vasc Interv Radiol. 2023 01; 34(1):116-123.e14.
PMID: 36167297
(More than) doubling down: Effective fibrinolysis at a reduced rt-PA dose for catheter-directed thrombolysis combined with histotripsy.
(More than) doubling down: Effective fibrinolysis at a reduced rt-PA dose for catheter-directed thrombolysis combined with histotripsy. PLoS One. 2022; 17(1):e0261567.
PMID: 34982784
Assessment of histological characteristics, imaging markers, and rt-PA susceptibility of ex vivo venous thrombi.
Assessment of histological characteristics, imaging markers, and rt-PA susceptibility of ex vivo venous thrombi. Sci Rep. 2021 11 23; 11(1):22805.
PMID: 34815441
Clot Degradation Under the Action of Histotripsy Bubble Activity and a Lytic Drug.
Clot Degradation Under the Action of Histotripsy Bubble Activity and a Lytic Drug. IEEE Trans Ultrason Ferroelectr Freq Control. 2021 09; 68(9):2942-2952.
PMID: 33460375