Our Faculty

Joseph A. Piccirilli, PhD

Structural basis for promiscuity in ligand recognition by yjdF riboswitch.
Structural basis for promiscuity in ligand recognition by yjdF riboswitch. Cell Discov. 2024 Apr 02; 10(1):37.
PMID: 38565535

Structure-guided aminoacylation and assembly of chimeric RNAs.
Structure-guided aminoacylation and assembly of chimeric RNAs. bioRxiv. 2024 Mar 03.
PMID: 38464152

Post-Transcriptional Methylation of Mitochondrial-tRNA Differentially Contributes to Mitochondrial Pathology.
Post-Transcriptional Methylation of Mitochondrial-tRNA Differentially Contributes to Mitochondrial Pathology. bioRxiv. 2023 Dec 10.
PMID: 38106193

Genome-Wide Profiling of tRNA Using an Unexplored Reverse Transcriptase with High Processivity.
Genome-Wide Profiling of tRNA Using an Unexplored Reverse Transcriptase with High Processivity. bioRxiv. 2023 Dec 09.
PMID: 38106225

Crystal structure of a cap-independent translation enhancer RNA.
Crystal structure of a cap-independent translation enhancer RNA. Nucleic Acids Res. 2023 09 08; 51(16):8891-8907.
PMID: 37548413

Reinvestigating the Synthesis and Characterization of Ethyl 3-[5-(2-Ethoxycarbonyl-1-methylvinyloxy)-1-methyl-1H-indol-3-yl]-but-2-enoate.
Reinvestigating the Synthesis and Characterization of Ethyl 3-[5-(2-Ethoxycarbonyl-1-methylvinyloxy)-1-methyl-1H-indol-3-yl]-but-2-enoate. ACS Omega. 2023 Sep 05; 8(35):31941-31945.
PMID: 37692243

Rapid Kinetics of Pistol Ribozyme: Insights into Limits to RNA Catalysis.
Rapid Kinetics of Pistol Ribozyme: Insights into Limits to RNA Catalysis. Biochemistry. 2023 07 04; 62(13):2079-2092.
PMID: 37294744

A general and efficient approach to synthesize the phosphoramidites of 5'-18O labeled purine nucleosides.
A general and efficient approach to synthesize the phosphoramidites of 5'-18O labeled purine nucleosides. Nucleosides Nucleotides Nucleic Acids. 2023; 42(11):930-943.
PMID: 37233721

Dissociative Transition State in Hepatitis Delta Virus Ribozyme Catalysis.
Dissociative Transition State in Hepatitis Delta Virus Ribozyme Catalysis. J Am Chem Soc. 2023 02 08; 145(5):2830-2839.
PMID: 36706353

Demethylation of dimethyl phosphonate esters with sodium ethanethiolate: Improved synthesis of 5'-methylene substituted 2',5'-deoxyribonucleotides.
Demethylation of dimethyl phosphonate esters with sodium ethanethiolate: Improved synthesis of 5'-methylene substituted 2',5'-deoxyribonucleotides. Nucleosides Nucleotides Nucleic Acids. 2023; 42(7):538-546.
PMID: 36629008

View All Publications