Our Faculty

Long Chi Nguyen

Long completed his medical training in Vietnam and graduated as valedictorian position. He completed his PhD degree in Japan at Tohoku University and is currently a Pathways to Independence Instructor at the University of Chicago with a main focus in breast cancer. Long is broadly interested in how hypoxia in the tumor microenvironment reprograms tumor cells which causes therapeutic resistance and promotes metastasis. His goal now is to elucidate the role of metastasis drivers in reprogramming the tumor microenvironment and assess its therapeutic potential, particularly for patients with triple negative breast cancer. His aspiration is to pursue a tenure-track position in academia in the United States, with a particular focus on becoming a part of an advancing translational research team dedicated to cancer.

Tohoku University Graduate School of Medicine
Sendai, Japan
PhD - Medical Science
2020

Hue University of Medicine and Pharmacy
Vietnam
MD - Odonto-Stomatology
2015

Heme regulates protein interactions and phosphorylation of BACH2 intrinsically disordered region in humoral response.
Heme regulates protein interactions and phosphorylation of BACH2 intrinsically disordered region in humoral response. iScience. 2025 Jan 17; 28(1):111529.
PMID: 39758820

Direct inhibition of tumor hypoxia response with synthetic transcriptional repressors.
Direct inhibition of tumor hypoxia response with synthetic transcriptional repressors. Nat Chem Biol. 2025 Feb; 21(2):247-255.
PMID: 39215099

Nonmonotone invasion landscape by noise-aware control of metastasis activator levels.
Nonmonotone invasion landscape by noise-aware control of metastasis activator levels. Nat Chem Biol. 2023 07; 19(7):887-899.
PMID: 37231268

Young researchers series #8.
Young researchers series #8. Trends Cell Biol. 2023 04; 33(4):273-276.
PMID: 36710232

SARS-CoV-2 Diverges from Other Betacoronaviruses in Only Partially Activating the IRE1a/XBP1 Endoplasmic Reticulum Stress Pathway in Human Lung-Derived Cells.
SARS-CoV-2 Diverges from Other Betacoronaviruses in Only Partially Activating the IRE1a/XBP1 Endoplasmic Reticulum Stress Pathway in Human Lung-Derived Cells. mBio. 2022 10 26; 13(5):e0241522.
PMID: 36125275

SARS-CoV-2 diverges from other betacoronaviruses in only partially activating the IRE1a/XBP1 ER stress pathway in human lung-derived cells.
SARS-CoV-2 diverges from other betacoronaviruses in only partially activating the IRE1a/XBP1 ER stress pathway in human lung-derived cells. bioRxiv. 2022 Jun 13.
PMID: 35821981

mTORC1-independent translation control in mammalian cells by methionine adenosyltransferase 2A and S-adenosylmethionine.
mTORC1-independent translation control in mammalian cells by methionine adenosyltransferase 2A and S-adenosylmethionine. J Biol Chem. 2022 07; 298(7):102084.
PMID: 35636512

Cannabidiol inhibits SARS-CoV-2 replication through induction of the host ER stress and innate immune responses.
Cannabidiol inhibits SARS-CoV-2 replication through induction of the host ER stress and innate immune responses. Sci Adv. 2022 Feb 25; 8(8):eabi6110.
PMID: 35050692

Limited inhibition of multiple nodes in a driver network blocks metastasis.
Limited inhibition of multiple nodes in a driver network blocks metastasis. Elife. 2021 05 11; 10.
PMID: 33973518

Cannabidiol Inhibits SARS-CoV-2 Replication and Promotes the Host Innate Immune Response.
Cannabidiol Inhibits SARS-CoV-2 Replication and Promotes the Host Innate Immune Response. bioRxiv. 2021 Mar 10.
PMID: 33758843

View All Publications

Susan G. Komen Career Transition Award
University of Chicago
2024 - 2029

Sigal Fellowship (Immuno-Oncology)
University of Chicago
2023 - 2024

AACR scholar-in-training award
American Association for Cancer Research
2023

Valedictorian
Hue University of Medicine and Pharmacy
2015