I am an endocrinologist/ diabetologist with a particular interest in technology driven solutions to complex management issues in diabetes. I am a past president of the American Diabetes Association (2019) and a Laureate of the Lincoln Academy of Illinois (https://lincolnacademyillinois.org/). My clinic focuses on type 1, type 2 diabetes, all forms of monogenic diabetes, transplant-related diabetes, cystic fibrosis-related diabetes, complications of diabetes and associated rare and atypical forms of diabetes and hypoglycemia. We incorporate all aspects of diabetes technology including insulin pumps and continuous glucose monitors locally and for use in telemedicine applications. Our diabetes team includes nurses, registered dietician-diabetes educators, pharmacists, podiatrists and a "Health and Wellness" team embedded in the clinic supported by the Department of Psychiatry. The Kovler Diabetes Center is more fully described at https://www.uchicagomedicine.org/conditions-services/diabetes.
One of the most exciting translational research areas is our diabetes genetics clinic associated with multiple research studies. We are the leading group in the United States for monogenic diabetes, helping to diagnose and manage patients with all forms of neonatal and MODY-type diabetes. Patients and referring physicians frequently reach us through our website: http://monogenicdiabetes.uchicago.edu. We have formed the Predict consortium to improve the diagnosis and treatment of monogenic diabetes We are also leading a study on new forms of atypical diabetes: https://www.atypicaldiabetesnetwork.org/. We also offer multiple research studies for early prevention and intervention in newly diagnosed Type 1 diabetes and are helping to understand polyautoimmunities that include T1D https://precisiont1d.uchicago.edu/.
Gain-of-function mutation in SKAP2 leads to type 1 diabetes and broader autoimmunity through hyperactive integrin signaling in myeloid cells.
Gain-of-function mutation in SKAP2 leads to type 1 diabetes and broader autoimmunity through hyperactive integrin signaling in myeloid cells. bioRxiv. 2026 Apr 06.
PMID: 41993266
Approach to the Patient: Mitochondrial Diabetes: Contemporary Cases and a Precision Medicine Approach.
Approach to the Patient: Mitochondrial Diabetes: Contemporary Cases and a Precision Medicine Approach. J Clin Endocrinol Metab. 2026 Mar 17; 111(4):1175-1186.
PMID: 41472381
Monogenic Type 1 Diabetes: A High Yield Pool in Which to Discover New Mechanisms and Candidate Therapeutics for Type 1 Diabetes.
Monogenic Type 1 Diabetes: A High Yield Pool in Which to Discover New Mechanisms and Candidate Therapeutics for Type 1 Diabetes. Cold Spring Harb Perspect Med. 2026 02 02; 16(2).
PMID: 39694696
Obstructive Sleep Apnea, Resting Heart Rate, and Glycemic Variability in Adults With Maturity-Onset Diabetes of the Young.
Obstructive Sleep Apnea, Resting Heart Rate, and Glycemic Variability in Adults With Maturity-Onset Diabetes of the Young. Diabetes. 2026 01 01; 75(1):215-222.
PMID: 41232044
Creation and Evaluation of a Research Participant Portal for the University of Chicago Monogenic Diabetes Registry.
Creation and Evaluation of a Research Participant Portal for the University of Chicago Monogenic Diabetes Registry. J Diabetes Sci Technol. 2025 Dec 11; 19322968251399666.
PMID: 41383073
Sleep patterns in adults and children with less common forms of diabetes.
Sleep patterns in adults and children with less common forms of diabetes. Front Endocrinol (Lausanne). 2025; 16:1388995.
PMID: 41158621
Antibody-Positive Type 1 Diabetes in a Family With a Pathogenic HNF1A-MODY Variant and Variable Age of Onset.
Antibody-Positive Type 1 Diabetes in a Family With a Pathogenic HNF1A-MODY Variant and Variable Age of Onset. JCEM Case Rep. 2025 Nov; 3(11):luaf229.
PMID: 41064662
Advancing Monogenic Diabetes Research and Clinical Care by Creating a Data Commons: The Precision Diabetes Consortium (PREDICT).
Advancing Monogenic Diabetes Research and Clinical Care by Creating a Data Commons: The Precision Diabetes Consortium (PREDICT). J Diabetes Sci Technol. 2026 May; 20(3):1034-1040.
PMID: 39781649
Monogenic Type 1 Diabetes: A High Yield Pool in Which to Discover New Mechanisms and Candidate Therapeutics for Type 1 Diabetes.
Monogenic Type 1 Diabetes: A High Yield Pool in Which to Discover New Mechanisms and Candidate Therapeutics for Type 1 Diabetes. Cold Spring Harb Perspect Med. 2024 Dec 18.
PMID: 39694696
Clinical Characteristics and Remission Monitoring of 6q24-Related Transient Neonatal Diabetes.
Clinical Characteristics and Remission Monitoring of 6q24-Related Transient Neonatal Diabetes. Pediatr Diabetes. 2024; 2024:3624339.
PMID: 40302951