Our lab aims to understand how natural selection has contributed to the evolution of our species and to which extent past selection events impact present-day susceptibility to disease. Specifically, our group studies the genetic basis of differences in immune response among different individuals and human populations as well as the phenotypic evolution of immune responses in primates. Most projects in the lab are multidisciplinary and combine the use of cutting edge genomic techniques with immunological and evolutionary genetic tools.
University of Chicago
Chicago
Post-doc - Functional Genomics
2011
University of Paris VII
Paris
PhD - Population Genetics
2008
Lusófona University
Lisbon
Master - Biotechnological Engineering
2003
Author Correction: Evolution of immune genes is associated with the Black Death.
Author Correction: Evolution of immune genes is associated with the Black Death. Nature. 2025 Jan 15.
PMID: 39814901
ß-Glucan reprograms neutrophils to promote disease tolerance against influenza A virus.
ß-Glucan reprograms neutrophils to promote disease tolerance against influenza A virus. Nat Immunol. 2025 Jan 08.
PMID: 39779870
Molecular profiles of blood from numerous species that differ in sensitivity to acute inflammation.
Molecular profiles of blood from numerous species that differ in sensitivity to acute inflammation. Mol Med. 2024 Dec 28; 30(1):280.
PMID: 39730996
Impact of disease-associated chromatin accessibility QTLs across immune cell types and contexts.
Impact of disease-associated chromatin accessibility QTLs across immune cell types and contexts. medRxiv. 2024 Dec 12.
PMID: 39711700
Widespread gene-environment interactions shape the immune response to SARS-CoV-2 infection in hospitalized COVID-19 patients.
Widespread gene-environment interactions shape the immune response to SARS-CoV-2 infection in hospitalized COVID-19 patients. bioRxiv. 2024 Dec 04.
PMID: 39677792
BCG vaccination alters the epigenetic landscape of progenitor cells in human bone marrow to influence innate immune responses.
BCG vaccination alters the epigenetic landscape of progenitor cells in human bone marrow to influence innate immune responses. Immunity. 2024 09 10; 57(9):2095-2107.e8.
PMID: 39153479
A female-biased gene expression signature of dominance in cooperatively breeding meerkats.
A female-biased gene expression signature of dominance in cooperatively breeding meerkats. Mol Ecol. 2024 Nov; 33(21):e17467.
PMID: 39021304
High-throughput screen identifies non inflammatory small molecule inducers of trained immunity.
High-throughput screen identifies non inflammatory small molecule inducers of trained immunity. Proc Natl Acad Sci U S A. 2024 Jul 16; 121(29):e2400413121.
PMID: 38976741
Sustained IFN signaling is associated with delayed development of SARS-CoV-2-specific immunity.
Sustained IFN signaling is associated with delayed development of SARS-CoV-2-specific immunity. Nat Commun. 2024 May 16; 15(1):4177.
PMID: 38755196
A host-directed oxadiazole compound potentiates antituberculosis treatment via zinc poisoning in human macrophages and in a mouse model of infection.
A host-directed oxadiazole compound potentiates antituberculosis treatment via zinc poisoning in human macrophages and in a mouse model of infection. PLoS Biol. 2024 Apr; 22(4):e3002259.
PMID: 38683873