Our lab aims to understand how natural selection has contributed to the evolution of our species and to which extent past selection events impact present-day susceptibility to disease. Specifically, our group studies the genetic basis of differences in immune response among different individuals and human populations as well as the phenotypic evolution of immune responses in primates. Most projects in the lab are multidisciplinary and combine the use of cutting edge genomic techniques with immunological and evolutionary genetic tools.
University of Chicago
Chicago
Post-doc - Functional Genomics
2011
University of Paris VII
Paris
PhD - Population Genetics
2008
Lusófona University
Lisbon
Master - Biotechnological Engineering
2003
Human alveolar macrophage metabolism is compromised during Mycobacterium tuberculosis infection.
Human alveolar macrophage metabolism is compromised during Mycobacterium tuberculosis infection. Front Immunol. 2022; 13:1044592.
PMID: 36776396
GATA4 controls regionalization of tissue immunity and commensal-driven immunopathology.
GATA4 controls regionalization of tissue immunity and commensal-driven immunopathology. Immunity. 2023 01 10; 56(1):43-57.e10.
PMID: 36630917
Neonatal imprinting of alveolar macrophages via neutrophil-derived 12-HETE.
Neonatal imprinting of alveolar macrophages via neutrophil-derived 12-HETE. Nature. 2023 Feb; 614(7948):530-538.
PMID: 36599368
Evolution of immune genes is associated with the Black Death.
Evolution of immune genes is associated with the Black Death. Nature. 2022 Nov; 611(7935):312-319.
PMID: 36261521
Aberrant T-cell exhaustion in severe combined immunodeficiency survivors with poor T-cell reconstitution after transplantation.
Aberrant T-cell exhaustion in severe combined immunodeficiency survivors with poor T-cell reconstitution after transplantation. J Allergy Clin Immunol. 2023 01; 151(1):260-271.
PMID: 35987350
Mitochondrial cyclophilin D promotes disease tolerance by licensing NK cell development and IL-22 production against influenza virus.
Mitochondrial cyclophilin D promotes disease tolerance by licensing NK cell development and IL-22 production against influenza virus. Cell Rep. 2022 06 21; 39(12):110974.
PMID: 35732121
Synchrony and idiosyncrasy in the gut microbiome of wild baboons.
Synchrony and idiosyncrasy in the gut microbiome of wild baboons. Nat Ecol Evol. 2022 07; 6(7):955-964.
PMID: 35654895
High molecular weight DNA extraction strategies for long-read sequencing of complex metagenomes.
High molecular weight DNA extraction strategies for long-read sequencing of complex metagenomes. Mol Ecol Resour. 2022 Jul; 22(5):1786-1802.
PMID: 35068060
Lack of evidence for intergenerational inheritance of immune resistance to infections.
Lack of evidence for intergenerational inheritance of immune resistance to infections. Nat Immunol. 2022 02; 23(2):203-207.
PMID: 35058614
Agonism and grooming behaviour explain social status effects on physiology and gene regulation in rhesus macaques.
Agonism and grooming behaviour explain social status effects on physiology and gene regulation in rhesus macaques. Philos Trans R Soc Lond B Biol Sci. 2022 02 28; 377(1845):20210132.
PMID: 35000435