The Torcasso Lab investigates spatial patterns of disease within the native tissue environment, bridging scientific discovery and clinical application. Focusing on tumor–immune interactions, we develop and apply computational methods to analyze high-dimensional spatial proteomic and transcriptomic data, uncovering how cellular organization and communication drive disease progression and therapeutic response. By integrating AI with spatial omics, we seek to identify spatial biomarkers and gain mechanistic insight into the function and dysfunction of the tumor–immune microenvironment. In close partnership with clinical collaborators, we aim to understand how the spatial context of immune and stromal cells shapes cancer evolution and treatment resistance.
Spatial statistics infer structured immune signatures in primary prostate cancer.
Spatial statistics infer structured immune signatures in primary prostate cancer. Cancer Immunol Res. 2026 Sep 11.
PMID: 42726512
Correcting Axial Length-Related Magnification Errors in Optical Coherence Tomography Angiography Improves Machine Learning Classification Performance in High Myopia.
Correcting Axial Length-Related Magnification Errors in Optical Coherence Tomography Angiography Improves Machine Learning Classification Performance in High Myopia. Clin Exp Ophthalmol. 2026 Sep 01.
PMID: 42680594
Autoreactive antibody production by intrarenal B cells in mouse kidney allograft rejection.
Autoreactive antibody production by intrarenal B cells in mouse kidney allograft rejection. bioRxiv. 2026 Jun 19.
PMID: 42368011
High-dimensional spatial proteomics and novel machine learning pipeline identifies disease specific renal damage states.
High-dimensional spatial proteomics and novel machine learning pipeline identifies disease specific renal damage states. bioRxiv. 2026 Jan 15.
PMID: 41648405
Virtual multiplex immunofluorescence identifies lymphocyte subsets predictive of response to neoadjuvant therapy.
Virtual multiplex immunofluorescence identifies lymphocyte subsets predictive of response to neoadjuvant therapy. Ther Adv Med Oncol. 2025; 17:17588359251379411.
PMID: 41142474
Spatially organized lymphocytic microenvironments in high grade primary prostate tumors.
Spatially organized lymphocytic microenvironments in high grade primary prostate tumors. bioRxiv. 2025 Sep 21.
PMID: 41000797
Immune cell quantification of in situ inflammation partitions human lupus nephritis into mechanistic subtypes.
Immune cell quantification of in situ inflammation partitions human lupus nephritis into mechanistic subtypes. J Clin Invest. 2025 11 03; 135(21).
PMID: 40906524
Pseudo-spectral angle mapping for pixel and cell classification in highly multiplexed immunofluorescence images.
Pseudo-spectral angle mapping for pixel and cell classification in highly multiplexed immunofluorescence images. J Med Imaging (Bellingham). 2024 Nov; 11(6):067502.
PMID: 39664650
BRWD1 establishes epigenetic states for germinal center initiation, maintenance, and function.
BRWD1 establishes epigenetic states for germinal center initiation, maintenance, and function. bioRxiv. 2024 Apr 28.
PMID: 38712068
Towards standardising retinal OCT angiography image analysis with open-source toolbox OCTAVA.
Towards standardising retinal OCT angiography image analysis with open-source toolbox OCTAVA. Sci Rep. 2024 03 12; 14(1):5979.
PMID: 38472220