My lab studies how populations of neurons implement decision making and motor control. We record and manipulate the activity of hundreds or thousands of neurons in mouse cortex, then use sophisticated analyses to understand how these areas compute variables that the animal needs in order to behave. With calcium imaging, we can identify each neuron's cell type, layer, or projection pattern, and use this information to better understand inter-area communication and the organization of computation within cortex. With optogenetics, we can close the causal loop to determine if the activity is necessary or the roles of cell types in computation. Finally, with pharmacological manipulations, we can begin to understand how psychiatric drugs drive their behavioral effects.
Cold Spring Harbor Laboratory
Cold Spring Harbor, NY
- Neuroscience
2018
Stanford University
Stanford, CA
PhD - Neuroscience
2011
Stanford University
Stanford, CA
BS - Symbolic Systems
2005
Reach-dependent reorientation of rotational dynamics in motor cortex.
Reach-dependent reorientation of rotational dynamics in motor cortex. Nat Commun. 2024 Aug 15; 15(1):7007.
PMID: 39143078
Microstimulation of human somatosensory cortex evokes task-dependent, spatially patterned responses in motor cortex.
Microstimulation of human somatosensory cortex evokes task-dependent, spatially patterned responses in motor cortex. Nat Commun. 2023 11 10; 14(1):7270.
PMID: 37949923
A deep learning framework for inference of single-trial neural population dynamics from calcium imaging with subframe temporal resolution.
A deep learning framework for inference of single-trial neural population dynamics from calcium imaging with subframe temporal resolution. Nat Neurosci. 2022 12; 25(12):1724-1734.
PMID: 36424431
The implications of categorical and category-free mixed selectivity on representational geometries.
The implications of categorical and category-free mixed selectivity on representational geometries. Curr Opin Neurobiol. 2022 12; 77:102644.
PMID: 36332415
BRICseq Bridges Brain-wide Interregional Connectivity to Neural Activity and Gene Expression in Single Animals.
BRICseq Bridges Brain-wide Interregional Connectivity to Neural Activity and Gene Expression in Single Animals. Cell. 2020 Dec 23; 183(7):2040.
PMID: 33357401
Neural population dynamics in motor cortex are different for reach and grasp.
Neural population dynamics in motor cortex are different for reach and grasp. Elife. 2020 11 17; 9.
PMID: 33200745
BRICseq Bridges Brain-wide Interregional Connectivity to Neural Activity and Gene Expression in Single Animals.
BRICseq Bridges Brain-wide Interregional Connectivity to Neural Activity and Gene Expression in Single Animals. Cell. 2020 07 09; 182(1):177-188.e27.
PMID: 32619423
Publisher Correction: Development of an optogenetic toolkit for neural circuit dissection in squirrel monkeys.
Publisher Correction: Development of an optogenetic toolkit for neural circuit dissection in squirrel monkeys. Sci Rep. 2019 Dec 05; 9(1):18775.
PMID: 31801956
Single-trial neural dynamics are dominated by richly varied movements.
Single-trial neural dynamics are dominated by richly varied movements. Nat Neurosci. 2019 10; 22(10):1677-1686.
PMID: 31551604
Accurate Estimation of Neural Population Dynamics without Spike Sorting.
Accurate Estimation of Neural Population Dynamics without Spike Sorting. Neuron. 2019 07 17; 103(2):292-308.e4.
PMID: 31171448
McKnight Foundation Allison Doupe Fellowship
Cold Spring Harbor Laboratory
2015 - 2015
Simons Collaboration on the Global Brain postdoctoral fellowship
Cold Spring Harbor Laboratory
2015 - 2018
Swartz Postdoctoral Fellowship
Cold Spring Harbor Laboratory
2013 - 2015
NSF GRFP
Stanford University
2006 - 2010