Dr. Dulin’s laboratory investigates the signaling mechanisms of TGF-beta-induced myofibroblast differentiation as related to pathogenesis of pulmonary fibrosis, using cell culture and animal models of the disease. His studies have described the critical role for serum response factor (SRF) in myofibroblast differentiation and pulmonary fibrosis, as well as the control of this pathway by actin and microtubule dynamics. The other direction of Dr. Dulin research relates to the basic studies on the biological function of the regulators of G protein signaling (RGS) proteins, focusing on RGS3 member of the family. His group has shown that RGS3 regulates the signaling mediated by heterotrimeric Gi and Gq proteins, as well as non-canonically of TGF-beta signaling. Together with Dr. Anne Sperling, they established the role of RGS3 in control of T cell migration and T cell – mediated inflammation, using knock-down and knockout approaches. His current studies focus on the function of endogenous RGS3 as related to cancer cell growth, migration and EMT.
Dr. Dulin's NIH Commons ID is NDULIN
LRRC8A-containing anion channels promote glioblastoma proliferation via a WNK1/mTORC2-dependent mechanism.
LRRC8A-containing anion channels promote glioblastoma proliferation via a WNK1/mTORC2-dependent mechanism. bioRxiv. 2025 Feb 06.
PMID: 39975357
Ga12 and Ga13 proteins are required for transforming growth factor-ß-induced myofibroblast differentiation.
Ga12 and Ga13 proteins are required for transforming growth factor-ß-induced myofibroblast differentiation. Biochem J. 2024 12 18; 481(24):1937-1948.
PMID: 39621448
Critical role of Ga12 and Ga13 proteins in TGF-ß-induced myofibroblast differentiation.
Critical role of Ga12 and Ga13 proteins in TGF-ß-induced myofibroblast differentiation. bioRxiv. 2024 May 30.
PMID: 38854083
Anoctamin-1 is induced by TGF-ß and contributes to lung myofibroblast differentiation.
Anoctamin-1 is induced by TGF-ß and contributes to lung myofibroblast differentiation. Am J Physiol Lung Cell Mol Physiol. 2024 01 01; 326(1):L111-L123.
PMID: 38084409
Anoctamin-1 is induced by TGF-beta and contributes to lung myofibroblast differentiation.
Anoctamin-1 is induced by TGF-beta and contributes to lung myofibroblast differentiation. bioRxiv. 2023 Nov 09.
PMID: 37333255
Memory Precursors and Short-Lived Effector T cell Subsets Have Different Sensitivities to TGFß.
Memory Precursors and Short-Lived Effector T cell Subsets Have Different Sensitivities to TGFß. Int J Mol Sci. 2023 Feb 15; 24(4).
PMID: 36835342
Identification of a Cardiac Glycoside Exhibiting Favorable Brain Bioavailability and Potency for Reducing Levels of the Cellular Prion Protein.
Identification of a Cardiac Glycoside Exhibiting Favorable Brain Bioavailability and Potency for Reducing Levels of the Cellular Prion Protein. Int J Mol Sci. 2022 Nov 26; 23(23).
PMID: 36499150
Calcium-Activated Chloride Channel ANO1/TMEM16A: Regulation of Expression and Signaling.
Calcium-Activated Chloride Channel ANO1/TMEM16A: Regulation of Expression and Signaling. Front Physiol. 2020; 11:590262.
PMID: 33250781
Na,K-ATPase as a target for endogenous cardiotonic steroids: What's the evidence?
Na,K-ATPase as a target for endogenous cardiotonic steroids: What's the evidence? Genes Dis. 2021 May; 8(3):259-271.
PMID: 33997173
Glutamine Metabolism Is Required for Collagen Protein Synthesis in Lung Fibroblasts.
Glutamine Metabolism Is Required for Collagen Protein Synthesis in Lung Fibroblasts. Am J Respir Cell Mol Biol. 2019 11; 61(5):597-606.
PMID: 30973753