In feats of dynamic self-organization, visceral organ tissues transform into specific shapes that are vital for their function. The convergence of quantitative microscopy, computation, and genetic tools now enables access to the dynamic and mechanical processes by which tissues sculpt complex visceral organ shapes. Our lab addresses the collective cell behaviors and mechanical interactions between mesodermal and epithelial tissue layers that link genes to geometry. We combine whole-organ live imaging, genetic perturbations, computational microscopy, and analytic approaches from soft matter physics.
https://mitchelllab.uchicago.edu/
University of California
Santa Barbara
pdoc - Quantitative developmental biology
2024
University of Chicago
PhD - Physics
2018
University of Chicago
MS - Physics
2013
Protocol for 3D surface texture modeling and quantitative spectral decomposition analysis in Drosophila border cell clusters.
Protocol for 3D surface texture modeling and quantitative spectral decomposition analysis in Drosophila border cell clusters. STAR Protoc. 2024 09 20; 5(3):103048.
PMID: 39068652
Learning a conserved mechanism for early neuroectoderm morphogenesis.
Learning a conserved mechanism for early neuroectoderm morphogenesis. ArXiv. 2024 May 28.
PMID: 38855544
Learning a conserved mechanism for early neuroectoderm morphogenesis.
Learning a conserved mechanism for early neuroectoderm morphogenesis. bioRxiv. 2023 Dec 23.
PMID: 38187670
TubULAR: tracking in toto deformations of dynamic tissues via constrained maps.
TubULAR: tracking in toto deformations of dynamic tissues via constrained maps. Nat Methods. 2023 Dec; 20(12):1980-1988.
PMID: 38057529
Septins regulate border cell surface geometry, shape, and motility downstream of Rho in Drosophila.
Septins regulate border cell surface geometry, shape, and motility downstream of Rho in Drosophila. Dev Cell. 2023 08 07; 58(15):1399-1413.e5.
PMID: 37329886
Geometric control of myosin II orientation during axis elongation.
Geometric control of myosin II orientation during axis elongation. Elife. 2023 01 30; 12.
PMID: 36715100
Controlling the shape and topology of two-component colloidal membranes.
Controlling the shape and topology of two-component colloidal membranes. Proc Natl Acad Sci U S A. 2022 08 09; 119(32):e2204453119.
PMID: 35914159
Active Microphase Separation in Mixtures of Microtubules and Tip-Accumulating Molecular Motors.
Active Microphase Separation in Mixtures of Microtubules and Tip-Accumulating Molecular Motors. Phys Rev X. 2022 Jul-Sep; 12(3).
PMID: 36643940
Visceral organ morphogenesis via calcium-patterned muscle constrictions.
Visceral organ morphogenesis via calcium-patterned muscle constrictions. Elife. 2022 05 20; 11.
PMID: 35593701
Real-space origin of topological band gaps, localization, and reentrant phase transitions in gyroscopic metamaterials.
Real-space origin of topological band gaps, localization, and reentrant phase transitions in gyroscopic metamaterials. Phys Rev E. 2021 Aug; 104(2-2):025007.
PMID: 34525529