Dr. Nagele is an internationally recognized trauma anesthesiologist, researcher and educator. An authority on perioperative outcomes research, he focuses on to better predict, diagnose, prevent, and treat major cardiac events in surgical patients. He discovered that novel heart biomarkers may predict heart attacks in patients undergoing non-cardiac surgery.
He has also conducted ground-breaking work suggesting that a brief inhalation of nitrous oxide, commonly known as laughing gas, improves severe symptoms of depression and suicidal thoughts.
Purposeful Drug Repurposing.
Purposeful Drug Repurposing. JAMA Psychiatry. 2025 May 14.
PMID: 40366672
Cardiac Events after Electroconvulsive Therapy: Reply.
Cardiac Events after Electroconvulsive Therapy: Reply. Anesthesiology. 2025 Jun 01; 142(6):1191.
PMID: 40358351
Nitrous oxide activates layer 5 prefrontal neurons via SK2 channel inhibition for antidepressant effect.
Nitrous oxide activates layer 5 prefrontal neurons via SK2 channel inhibition for antidepressant effect. Nat Commun. 2025 Apr 03; 16(1):2999.
PMID: 40180931
Nitrous Oxide activates layer 5 prefrontal neurons via SK2 channel inhibition for antidepressant effect.
Nitrous Oxide activates layer 5 prefrontal neurons via SK2 channel inhibition for antidepressant effect. Res Sq. 2024 Nov 15.
PMID: 39606485
Management of Depression and Anxiety in Perioperative Medicine.
Management of Depression and Anxiety in Perioperative Medicine. Anesthesiology. 2024 Oct 01; 141(4):765-778.
PMID: 39136627
Nitrous Oxide Alters Functional Connectivity in Medial Limbic Structures in Treatment-Resistant Major Depression.
Nitrous Oxide Alters Functional Connectivity in Medial Limbic Structures in Treatment-Resistant Major Depression. medRxiv. 2024 Aug 17.
PMID: 39185528
Nitrous Oxide Reduced Suicidal Ideation in Treatment-Resistant Major Depression in Exploratory Analysis.
Nitrous Oxide Reduced Suicidal Ideation in Treatment-Resistant Major Depression in Exploratory Analysis. J Clin Psychiatry. 2023 08 16; 84(5).
PMID: 37585253
Treatments for major depression.
Treatments for major depression. Lancet. 2023 06 24; 401(10394):2111.
PMID: 37355289
Rare missense variants in the SH3 domain of PSTPIP1 are associated with hidradenitis suppurativa.
Rare missense variants in the SH3 domain of PSTPIP1 are associated with hidradenitis suppurativa. HGG Adv. 2023 04 13; 4(2):100187.
PMID: 37013170
Colonels and generals, chairs and deans: How the military educates its leaders and what we can learn in academic medicine.
Colonels and generals, chairs and deans: How the military educates its leaders and what we can learn in academic medicine. Front Health Serv. 2023; 3:1075543.
PMID: 36926510
Fellow
American Association for the Advancement of Science
2022
Austrian Cross of Honor for Science and Arts
Republic of Austria
2021
FAER Academy of Research Mentors in Anesthesiology (elected)
FAER
2019
Fellow
American Heart Association
2018
NARSAD Independent Investigator Grant
Brain & Behavior Research Foundation
2016
Ziskind-Somerfeld Research Award
Society for Biological Psychiatry
2016
Mentor of the Year
Clinical Research Training Center, Washington University School of Medicine
2014
Presidential Scholar Award
American Society of Anesthesiologists
2012
Billroth Prize
Vienna Medical Society (Austria)
2011
Elmer-Zsigmond Award
International Society for Anesthetic Pharmacology
2007
Otto-Kraupp-Prize
2006
Research Starter Grant
European Society of Anaesthesiology
2005
Resident’s Research Essay Contest Award
American Society for Anesthesiology
2005