Dr. Nagele is an internationally recognized trauma anesthesiologist, researcher and educator. An authority on perioperative outcomes research, he focuses on to better predict, diagnose, prevent, and treat major cardiac events in surgical patients. He discovered that novel heart biomarkers may predict heart attacks in patients undergoing non-cardiac surgery.
He has also conducted ground-breaking work suggesting that a brief inhalation of nitrous oxide, commonly known as laughing gas, improves severe symptoms of depression and suicidal thoughts.
Preoperative Assessment of Anxiety and Depression Using Computerized Adaptive Screening Tools: A Pilot Prospective Cohort Study.
Bass V, Brown F, Beiser DG, Peterson T, Gibbons RD, Nagele P. Preoperative Assessment of Anxiety and Depression Using Computerized Adaptive Screening Tools: A Pilot Prospective Cohort Study. Anesth Analg. 2022 04 01; 134(4):853-857.
PMID: 34958316
The Importance of Definitive Trials: The VIXIE Trial.
Nagele P. The Importance of Definitive Trials: The VIXIE Trial. Anesthesiology. 2022 03 01; 136(3):403-404.
PMID: 35120197
Normalized Subendocardial Myocardial Attenuation on Coronary Computed Tomography Angiography Predicts Postoperative Adverse Cardiovascular Events: Coronary CTA VISION Substudy.
Walpot J, Massalha S, Jayasinghe P, Sadaf M, Clarkin O, Godkin L, Sharma A, Ratnayake I, Godkin K, Jia K, Hossain A, Crean AM, Chan M, Butler C, Tandon V, Nagele P, Woodard PK, Mrkobrada M, Szczeklik W, Aziz YFA, Biccard B, Devereaux PJ, Sheth T, Chow BJW. Normalized Subendocardial Myocardial Attenuation on Coronary Computed Tomography Angiography Predicts Postoperative Adverse Cardiovascular Events: Coronary CTA VISION Substudy. Circ Cardiovasc Imaging. 2022 01; 15(1):e012654.
PMID: 35041449
Preoperative Assessment of Anxiety and Depression Using Computerized Adaptive Screening Tools: A Pilot Prospective Cohort Study.
Bass V, Brown F, Beiser DG, Peterson T, Gibbons RD, Nagele P. Preoperative Assessment of Anxiety and Depression Using Computerized Adaptive Screening Tools: A Pilot Prospective Cohort Study. Anesth Analg. 2021 Dec 24.
PMID: 34958316
Evaluation of Appropriate Use of Preoperative Echocardiography before Major Abdominal Surgery: A Retrospective Cohort Study.
Tank A, Hughey R, Ward RP, Nagele P, Rubin DS. Evaluation of Appropriate Use of Preoperative Echocardiography before Major Abdominal Surgery: A Retrospective Cohort Study. Anesthesiology. 2021 11 01; 135(5):854-863.
PMID: 34543408
NT-proBNP in young healthy adults undergoing non-cardiac surgery.
Duma A, Maleczek M, Wagner C, Haslacher H, Szekeres T, Jaffe AS, Nagele P. NT-proBNP in young healthy adults undergoing non-cardiac surgery. Clin Biochem. 2021 Oct; 96:38-42.
PMID: 34265286
A phase 2 trial of inhaled nitrous oxide for treatment-resistant major depression.
Nagele P, Palanca BJ, Gott B, Brown F, Barnes L, Nguyen T, Xiong W, Salloum NC, Espejo GD, Lessov-Schlaggar CN, Jain N, Cheng WWL, Komen H, Yee B, Bolzenius JD, Janski A, Gibbons R, Zorumski CF, Conway CR. A phase 2 trial of inhaled nitrous oxide for treatment-resistant major depression. Sci Transl Med. 2021 06 09; 13(597).
PMID: 34108247
Expert consensus on peri-operative myocardial injury screening in noncardiac surgery: A literature review.
Puelacher C, Bollen Pinto B, Mills NL, Duceppe E, Popova E, Duma A, Nagele P, Omland T, Hammerer-Lercher A, Lurati Buse G. Expert consensus on peri-operative myocardial injury screening in noncardiac surgery: A literature review. Eur J Anaesthesiol. 2021 Jun 01; 38(6):600-608.
PMID: 33653981
U.S. trends in elective and emergent major abdominal surgical procedures from 2002 to 2014 in older adults.
Rubin DS, Huisingh-Scheetz M, Ferguson MK, Nagele P, Peden CJ, Lauderdale DS. U.S. trends in elective and emergent major abdominal surgical procedures from 2002 to 2014 in older adults. J Am Geriatr Soc. 2021 08; 69(8):2220-2230.
PMID: 33969889
Frequency and Outcomes of Preoperative Stress Testing in Total Hip and Knee Arthroplasty from 2004 to 2017.
Rubin DS, Hughey R, Gerlach RM, Ham SA, Ward RP, Nagele P. Frequency and Outcomes of Preoperative Stress Testing in Total Hip and Knee Arthroplasty from 2004 to 2017. JAMA Cardiol. 2021 01 01; 6(1):13-20.
PMID: 32997100
Fellow
American Heart Association
2018
NARSAD Independent Investigator Grant
Brain & Behavior Research Foundation
2016
Ziskind-Somerfeld Research Award
Society for Biological Psychiatry
2016
Mentor of the Year
Clinical Research Training Center, Washington University School of Medicine
2014
Presidential Scholar Award
American Society of Anesthesiologists
2012
Billroth Prize
Vienna Medical Society (Austria)
2011
Elmer-Zsigmond Award
International Society for Anesthetic Pharmacology
2007
Otto-Kraupp-Prize
2006
Research Starter Grant
European Society of Anaesthesiology
2005
Resident’s Research Essay Contest Award
American Society for Anesthesiology
2005