We study the molecular mechanisms underlying membrane protein biogenesis and quality control using biochemical, structural and cell biology approaches.
UCSF
San Francisco, CA
Postdoc - Biochemistry and Biophysics
1999
UCSF
San Francisco, CA
PHD - Biochemistry and Biophysics
1998
Bates College
Lewiston, ME
BS - Biology and Chemistry
1990
Structural basis of regulated N-glycosylation at the secretory translocon.
Structural basis of regulated N-glycosylation at the secretory translocon. Nature. 2026 Jan; 649(8097):777-784.
PMID: 41261126
Global analysis of translocon remodeling during protein synthesis at the ER.
Global analysis of translocon remodeling during protein synthesis at the ER. Nat Struct Mol Biol. 2025 Dec; 32(12):2517-2525.
PMID: 41116047
Corrigendum to: Lobectomy, segmentectomy, or wedge resection for peripheral clinical T1aN0 non-small cell lung cancer: A post hoc analysis of CALGB 140503 (Alliance)" [The Journal of Thoracic and Cardiovascular Surgery Volume 167, Issue 1, January 2024, Pages 338-347.e1].
Corrigendum to: Lobectomy, segmentectomy, or wedge resection for peripheral clinical T1aN0 non-small cell lung cancer: A post hoc analysis of CALGB 140503 (Alliance)" [The Journal of Thoracic and Cardiovascular Surgery Volume 167, Issue 1, January 2024, Pages 338-347.e1]. J Thorac Cardiovasc Surg. 2025 Apr; 169(4):1181.
PMID: 39708006
snoRNA-facilitated protein secretion revealed by transcriptome-wide snoRNA target identification.
snoRNA-facilitated protein secretion revealed by transcriptome-wide snoRNA target identification. Cell. 2025 Jan 23; 188(2):465-483.e22.
PMID: 39579764
The prolyl isomerase FKBP11 is a secretory translocon accessory factor.
The prolyl isomerase FKBP11 is a secretory translocon accessory factor. Mol Biol Cell. 2024 Nov 01; 35(11):ar135.
PMID: 39259761
Structural analysis of the dynamic ribosome-translocon complex.
Structural analysis of the dynamic ribosome-translocon complex. Elife. 2024 Jun 18; 13.
PMID: 38896445
A unifying model for membrane protein biogenesis.
A unifying model for membrane protein biogenesis. Nat Struct Mol Biol. 2024 Jul; 31(7):1009-1017.
PMID: 38811793
Secondary Analysis of the Rate of Second Primary Lung Cancer From Cancer and Leukemia Group B 140503 (Alliance) Trial of Lobar Versus Sublobar Resection for T1aN0 Non-Small-Cell Lung Cancer.
Secondary Analysis of the Rate of Second Primary Lung Cancer From Cancer and Leukemia Group B 140503 (Alliance) Trial of Lobar Versus Sublobar Resection for T1aN0 Non-Small-Cell Lung Cancer. J Clin Oncol. 2024 Apr 01; 42(10):1110-1113.
PMID: 38215351
Factors Associated with Self-reported COVID-19 Infection and Hospitalization among Patients Seeking Care at a Comprehensive Cancer Center.
Factors Associated with Self-reported COVID-19 Infection and Hospitalization among Patients Seeking Care at a Comprehensive Cancer Center. J Racial Ethn Health Disparities. 2025 Feb; 12(1):107-117.
PMID: 37917235
Examining disparities in large-scale patient-reported data capture using digital tools among cancer patients at clinical intake.
Examining disparities in large-scale patient-reported data capture using digital tools among cancer patients at clinical intake. Cancer Med. 2023 09; 12(18):19033-19046.
PMID: 37596773