We study the molecular mechanisms underlying membrane protein biogenesis and quality control using biochemical, structural and cell biology approaches.
UCSF
San Francisco, CA
Postdoc - Biochemistry and Biophysics
1999
UCSF
San Francisco, CA
PHD - Biochemistry and Biophysics
1998
Bates College
Lewiston, ME
BS - Biology and Chemistry
1990
Structural basis of regulated N-glycosylation at the secretory translocon.
Structural basis of regulated N-glycosylation at the secretory translocon. Nature. 2025 Nov 19.
PMID: 41261126
Global analysis of translocon remodeling during protein synthesis at the ER.
Global analysis of translocon remodeling during protein synthesis at the ER. Nat Struct Mol Biol. 2025 Oct 20.
PMID: 41116047
snoRNA-facilitated protein secretion revealed by transcriptome-wide snoRNA target identification.
snoRNA-facilitated protein secretion revealed by transcriptome-wide snoRNA target identification. Cell. 2025 Jan 23; 188(2):465-483.e22.
PMID: 39579764
The prolyl isomerase FKBP11 is a secretory translocon accessory factor.
The prolyl isomerase FKBP11 is a secretory translocon accessory factor. Mol Biol Cell. 2024 Nov 01; 35(11):ar135.
PMID: 39259761
Structural analysis of the dynamic ribosome-translocon complex.
Structural analysis of the dynamic ribosome-translocon complex. Elife. 2024 Jun 18; 13.
PMID: 38896445
A unifying model for membrane protein biogenesis.
A unifying model for membrane protein biogenesis. Nat Struct Mol Biol. 2024 Jul; 31(7):1009-1017.
PMID: 38811793
Factors Associated with Self-reported COVID-19 Infection and Hospitalization among Patients Seeking Care at a Comprehensive Cancer Center.
Factors Associated with Self-reported COVID-19 Infection and Hospitalization among Patients Seeking Care at a Comprehensive Cancer Center. J Racial Ethn Health Disparities. 2025 Feb; 12(1):107-117.
PMID: 37917235
Examining disparities in large-scale patient-reported data capture using digital tools among cancer patients at clinical intake.
Examining disparities in large-scale patient-reported data capture using digital tools among cancer patients at clinical intake. Cancer Med. 2023 09; 12(18):19033-19046.
PMID: 37596773
Substrate-driven assembly of a translocon for multipass membrane proteins.
Substrate-driven assembly of a translocon for multipass membrane proteins. Nature. 2022 11; 611(7934):167-172.
PMID: 36261522
Mechanism of an intramembrane chaperone for multipass membrane proteins.
Mechanism of an intramembrane chaperone for multipass membrane proteins. Nature. 2022 11; 611(7934):161-166.
PMID: 36261528