We study mechanosensory signaling by the inner ear. We focus on the mouse utricle, where we have access to mechanosensitive receptor cells and primary afferent neurons. In this simple circuit we can address fundamental neurobiological questions, such as mechanotransduction, the nature of a simple sensory map, how transmission occurs across unique calyceal synapses, and how different kinds of information are encoded in the spike rate and timing of primary afferent neurons.
Caltech
Pasadena CA
PhD - Biology
McGill University
Montreal
B.Sc. - Honours Neurobiology
McGill University
Montreal
M.Sc. - Biology
MIT & Harvard
Cambridge, Boston
- Auditory Physiology
A novel membrane contact site in vestibular hair cells.
A novel membrane contact site in vestibular hair cells. bioRxiv. 2025 Mar 24.
PMID: 40196657
KV1.8 (Kcna10) potassium channels enhance fast, linear signaling in vestibular hair cells and facilitate vestibulomotor reflexes and balance.
KV1.8 (Kcna10) potassium channels enhance fast, linear signaling in vestibular hair cells and facilitate vestibulomotor reflexes and balance. bioRxiv. 2025 Jan 28.
PMID: 39975259
The potassium channel subunit KV1.8 (Kcna10) is essential for the distinctive outwardly rectifying conductances of type I and II vestibular hair cells.
The potassium channel subunit KV1.8 (Kcna10) is essential for the distinctive outwardly rectifying conductances of type I and II vestibular hair cells. Elife. 2024 Dec 03; 13.
PMID: 39625061
Effects of transient, persistent, and resurgent sodium currents on excitability and spike regularity in vestibular ganglion neurons.
Effects of transient, persistent, and resurgent sodium currents on excitability and spike regularity in vestibular ganglion neurons. Front Neurol. 2024; 15:1471118.
PMID: 39624672
Contributions of mirror-image hair cell orientation to mouse otolith organ and zebrafish neuromast function.
Contributions of mirror-image hair cell orientation to mouse otolith organ and zebrafish neuromast function. Elife. 2024 Nov 12; 13.
PMID: 39531034
Contributions of mirror-image hair cell orientation to mouse otolith organ and zebrafish neuromast function.
Contributions of mirror-image hair cell orientation to mouse otolith organ and zebrafish neuromast function. bioRxiv. 2024 Sep 06.
PMID: 39282410
The potassium channel subunit KV1.8 (Kcna10) is essential for the distinctive outwardly rectifying conductances of type I and II vestibular hair cells.
The potassium channel subunit KV1.8 (Kcna10) is essential for the distinctive outwardly rectifying conductances of type I and II vestibular hair cells. bioRxiv. 2024 Aug 18.
PMID: 38045305
Effects of transient, persistent, and resurgent sodium currents on excitability and spike regularity in vestibular ganglion neurons.
Effects of transient, persistent, and resurgent sodium currents on excitability and spike regularity in vestibular ganglion neurons. bioRxiv. 2024 Jul 27.
PMID: 38076890
Effects of transient, persistent, and resurgent sodium currents on excitability and spike regularity in vestibular ganglion neurons.
Effects of transient, persistent, and resurgent sodium currents on excitability and spike regularity in vestibular ganglion neurons. bioRxiv. 2023 Nov 29.
PMID: 38076890
The potassium channel subunit KV1.8 (Kcna10) is essential for the distinctive outwardly rectifying conductances of type I and II vestibular hair cells.
The potassium channel subunit KV1.8 (Kcna10) is essential for the distinctive outwardly rectifying conductances of type I and II vestibular hair cells. bioRxiv. 2023 Nov 21.
PMID: 38045305