Dr. Liu's research focuses on uncovering the genetic basis and biological mechanisms of disease through the integration of computational genomics, statistical genetics, and human genetics. Dr. Liu is particularly interested in interpreting disease-associated genetic variants using functional genomics, single-cell omics, and gene regulatory networks. The lab also has a broad interest in understanding the genetic architectures of diseases across diverse populations and in enhancing the portability and accuracy of genetic prediction models.
Harvard School of Public Health
Boston, USA
Postdoc - Statistical Genetics
2017
National University of Singapore
Singapore, Singapore
PHD - Population Genetics
2014
National University of Singapore
Singapore, Singapore
Bachelor of Science - Computational Biology
2010
Trans-regulatory gene mapping prioritizes disease drivers in asthma.
Trans-regulatory gene mapping prioritizes disease drivers in asthma. Cell. 2026 Aug 20; 189(17):5250-5265.e11.
PMID: 42580338
Protein-protein interactions shape trans-regulatory impact of genetic variation on protein expression and complex traits.
Protein-protein interactions shape trans-regulatory impact of genetic variation on protein expression and complex traits. Nat Genet. 2026 01; 58(1):77-87.
PMID: 41501544
Allele frequency impacts the cross-ancestry portability of gene expression prediction in lymphoblastoid cell lines.
Allele frequency impacts the cross-ancestry portability of gene expression prediction in lymphoblastoid cell lines. Am J Hum Genet. 2024 12 05; 111(12):2814-2825.
PMID: 39549695
Trans-eQTL mapping in gene sets identifies network effects of genetic variants.
Trans-eQTL mapping in gene sets identifies network effects of genetic variants. Cell Genom. 2024 04 10; 4(4):100538.
PMID: 38565144
GBAT: a gene-based association test for robust detection of trans-gene regulation.
GBAT: a gene-based association test for robust detection of trans-gene regulation. Genome Biol. 2020 08 24; 21(1):211.
PMID: 32831138
Trans Effects on Gene Expression Can Drive Omnigenic Inheritance.
Trans Effects on Gene Expression Can Drive Omnigenic Inheritance. Cell. 2019 05 02; 177(4):1022-1034.e6.
PMID: 31051098