Dr. Yu-Ying He leads a research program focused on understanding how normal cells respond to environmental carcinogens and transform into cancerous cells. Her laboratory investigates the roles of epitranscriptomics, epigenetics, and autophagy in maintaining genomic integrity and cellular homeostasis, and how disruptions in these processes contribute to cancer development and therapeutic resistance.
With a particular emphasis on skin cancers—especially squamous cell carcinoma and melanoma—Dr. He’s research aims to uncover the molecular mechanisms that drive tumor initiation, progression, and resistance to treatment. Her long-term goal is to identify previously unrecognized, therapeutically accessible regulatory networks that influence susceptibility to skin cancer. Through this work, Dr. He seeks to advance the prevention and treatment of skin malignancies by providing novel molecular targets and predictive markers for clinical intervention.
Chinese Academy of Sciences
China
PhD - Organic Chemistry
2000
IL11-mediated stromal cell activation may not be the master regulator of pro-fibrotic signaling downstream of TGFß.
IL11-mediated stromal cell activation may not be the master regulator of pro-fibrotic signaling downstream of TGFß. Front Immunol. 2024; 15:1293883.
PMID: 38455057
miR-100a-5p-enriched exosomes derived from mesenchymal stem cells enhance the anti-oxidant effect in a Parkinson's disease model via regulation of Nox4/ROS/Nrf2 signaling.
miR-100a-5p-enriched exosomes derived from mesenchymal stem cells enhance the anti-oxidant effect in a Parkinson's disease model via regulation of Nox4/ROS/Nrf2 signaling. J Transl Med. 2023 10 24; 21(1):747.
PMID: 37875930
Autophagy of the m6A mRNA demethylase FTO is impaired by low-level arsenic exposure to promote tumorigenesis.
Autophagy of the m6A mRNA demethylase FTO is impaired by low-level arsenic exposure to promote tumorigenesis. Nat Commun. 2021 04 12; 12(1):2183.
PMID: 33846348
Keratinocyte autophagy enables the activation of keratinocytes and fibroblastsand facilitates wound healing.
Keratinocyte autophagy enables the activation of keratinocytes and fibroblastsand facilitates wound healing. Autophagy. 2021 09; 17(9):2128-2143.
PMID: 32866426
m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade.
m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade. Nat Commun. 2019 06 25; 10(1):2782.
PMID: 31239444
Phosphorylation of xeroderma pigmentosum group C regulates ultraviolet-induced DNA damage repair.
Phosphorylation of xeroderma pigmentosum group C regulates ultraviolet-induced DNA damage repair. Nucleic Acids Res. 2018 06 01; 46(10):5050-5060.
PMID: 29660033
The Role of Dynamic m6 A RNA Methylation in Photobiology.
The Role of Dynamic m6 A RNA Methylation in Photobiology. Photochem Photobiol. 2019 01; 95(1):95-104.
PMID: 29729018
Knockdown delta-5-desaturase in breast cancer cells that overexpress COX-2 results in inhibition of growth, migration and invasion via a dihomo-?-linolenic acid peroxidation dependent mechanism.
Knockdown delta-5-desaturase in breast cancer cells that overexpress COX-2 results in inhibition of growth, migration and invasion via a dihomo-?-linolenic acid peroxidation dependent mechanism. BMC Cancer. 2018 03 27; 18(1):330.
PMID: 29587668
Regulation of XPC deubiquitination by USP11 in repair of UV-induced DNA damage.
Regulation of XPC deubiquitination by USP11 in repair of UV-induced DNA damage. Oncotarget. 2017 Nov 14; 8(57):96522-96535.
PMID: 29228550
Epidermal SIRT1 regulates inflammation, cell migration, and wound healing.
Epidermal SIRT1 regulates inflammation, cell migration, and wound healing. Sci Rep. 2017 10 26; 7(1):14110.
PMID: 29074993