Our Faculty

Yu-Ying He, PhD

  • Professor of Medicine
    Committee on Cancer Biology
  • Research and Scholarly Interests: Arsenic, Autophagy, DNA damage, DNA Methylation, Epigenetics, m6A, Melanoma, Nucleotide Excision Repair, Photobiology, RNA modification, Skin Cancer, Squamous Cell Carcinoma, Ultraviolet radiation, UV
  • Websites: He Group, He Lab, Research Network Profile
  • Contact: yyhe@uchicago.edu
  • Graduate Program: Cancer Biology

Our research addresses the fundamental questions: how normal cells respond to environmental carcinogens and evolve into cancerous cells. In particular, our group focuses on the role of epitranscriptomics, epigenetics, and autophagy in regulating genomic integrity and cellular homeostasis and to investigate their impact on cancer development and therapeutic resistance, with an emphasis on skin cancer including squamous cancer and melanoma. Our long-term goal is to identify previously unrecognized, therapeutically accessible molecular regulatory networks that predict susceptibility to skin cancer, and improve our ability to prevent and treat these cancers.

Chinese Academy of Sciences
China
PhD - Organic Chemistry
2000

Autophagy of the m6A mRNA demethylase FTO is impaired by low-level arsenic exposure to promote tumorigenesis.
Cui YH, Yang S, Wei J, Shea CR, Zhong W, Wang F, Shah P, Kibriya MG, Cui X, Ahsan H, He C, He YY. Autophagy of the m6A mRNA demethylase FTO is impaired by low-level arsenic exposure to promote tumorigenesis. Nat Commun. 2021 04 12; 12(1):2183.
PMID: 33846348

Keratinocyte autophagy enables the activation of keratinocytes and fibroblastsand facilitates wound healing.
Qiang L, Yang S, Cui YH, He YY. Keratinocyte autophagy enables the activation of keratinocytes and fibroblastsand facilitates wound healing. Autophagy. 2021 Sep; 17(9):2128-2143.
PMID: 32866426

m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade.
Yang S, Wei J, Cui YH, Park G, Shah P, Deng Y, Aplin AE, Lu Z, Hwang S, He C, He YY. m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade. Nat Commun. 2019 06 25; 10(1):2782.
PMID: 31239444

Phosphorylation of xeroderma pigmentosum group C regulates ultraviolet-induced DNA damage repair.
Shah P, Zhao B, Qiang L, He YY. Phosphorylation of xeroderma pigmentosum group C regulates ultraviolet-induced DNA damage repair. Nucleic Acids Res. 2018 06 01; 46(10):5050-5060.
PMID: 29660033

The Role of Dynamic m6 A RNA Methylation in Photobiology.
Robinson M, Shah P, Cui YH, He YY. The Role of Dynamic m6 A RNA Methylation in Photobiology. Photochem Photobiol. 2019 01; 95(1):95-104.
PMID: 29729018

Knockdown delta-5-desaturase in breast cancer cells that overexpress COX-2 results in inhibition of growth, migration and invasion via a dihomo-?-linolenic acid peroxidation dependent mechanism.
Xu Y, Yang X, Wang T, Yang L, He YY, Miskimins K, Qian SY. Knockdown delta-5-desaturase in breast cancer cells that overexpress COX-2 results in inhibition of growth, migration and invasion via a dihomo-?-linolenic acid peroxidation dependent mechanism. BMC Cancer. 2018 03 27; 18(1):330.
PMID: 29587668

Regulation of XPC deubiquitination by USP11 in repair of UV-induced DNA damage.
Shah P, Qiang L, Yang S, Soltani K, He YY. Regulation of XPC deubiquitination by USP11 in repair of UV-induced DNA damage. Oncotarget. 2017 Nov 14; 8(57):96522-96535.
PMID: 29228550

Epidermal SIRT1 regulates inflammation, cell migration, and wound healing.
Qiang L, Sample A, Liu H, Wu X, He YY. Epidermal SIRT1 regulates inflammation, cell migration, and wound healing. Sci Rep. 2017 10 26; 7(1):14110.
PMID: 29074993

The Autophagy Receptor Adaptor p62 is Up-regulated by UVA Radiation in Melanocytes and in Melanoma Cells.
Sample A, Zhao B, Wu C, Qian S, Shi X, Aplin A, He YY. The Autophagy Receptor Adaptor p62 is Up-regulated by UVA Radiation in Melanocytes and in Melanoma Cells. Photochem Photobiol. 2018 05; 94(3):432-437.
PMID: 28715145

IL-17A induces heterogeneous macrophages, and it does not alter the effects of lipopolysaccharides on macrophage activation in the skin of mice.
Nakai K, He YY, Nishiyama F, Naruse F, Haba R, Kushida Y, Katsuki N, Moriue T, Yoneda K, Kubota Y. IL-17A induces heterogeneous macrophages, and it does not alter the effects of lipopolysaccharides on macrophage activation in the skin of mice. Sci Rep. 2017 09 29; 7(1):12473.
PMID: 28963556

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