Our Faculty

Yun Fang, PhD

My research foci are mechano-transduction mechanisms by which cells sense and convert environmental mechanical stimuli into biological signaling and novel nanomedicine approaches that target dysregulated mechano-sensing pathways. Cellular mechanotransduction is instrumental to embryogenesis and physiological control of tissue homeostasis; abnormal cell responses to mechanical forces promote pathologies associated with numerous human diseases. This is especially important in the vasculature, where environmental mechanical stimuli produce cellular responses in endothelial cells at arterial curvatures and bifurcations by locally disturbed blood flow to induce atherosclerosis. A similar cascade appears to be induced in acute lung injury where it is the increased cyclic stretch that is the trigger. My research program at the University of Chicago focuses on the molecular understanding of endothelial homeostasis governed by mechanical forces, with emphasis upon regulation of non-coding genome, transcription factors, G protein signaling, and genetic variance. Another major research goal is to develop innovative nanomedicine-based therapeutic strategies to treat dysregulated mechano-sensing mechanisms causing vascular diseases.



Key Words: microRNA, non-coding RNA, human genetics, enhancer biology, vascular biology, nanotechnology, nanomedicine, mechanotransduction, atherosclerosis, acute lung injury

University of Pennsylvania
USA
Postdoctoral Fellow - Medicine and Engineering
2012

University of Pennsylvania
USA
PhD - Bioengineering
2006

University of Pennsylvania
USA
MS - Biotechnology
2002

National Taiwan University
Taiwan
BS - Microbiology & Plant Pathology
1999

Single-cell metabolic imaging reveals a SLC2A3-dependent glycolytic burst in motile endothelial cells.
Wu D, Harrison DL, Szasz T, Yeh CF, Shentu TP, Meliton A, Huang RT, Zhou Z, Mutlu GM, Huang J, Fang Y. Single-cell metabolic imaging reveals a SLC2A3-dependent glycolytic burst in motile endothelial cells. Nat Metab. 2021 May; 3(5):714-727.
PMID: 34031595

SARS-CoV-2 Infection is Associated with Reduced Krüppel-Like Factor 2 in Human Lung Autopsy.
Wu D, Lee TH, Huang RT, Guzy R, Schoettler N, Adegunsoye A, Mueller J, Husain A, Sperling A, Mutlu GM, Fang Y. SARS-CoV-2 Infection is Associated with Reduced Krüppel-Like Factor 2 in Human Lung Autopsy. Am J Respir Cell Mol Biol. 2021 May 10.
PMID: 33971111

Tracking Longitudinal Rotation of Silicon Nanowires for Biointerfaces.
Lee YV, Wu D, Fang Y, Peng Y, Tian B. Tracking Longitudinal Rotation of Silicon Nanowires for Biointerfaces. Nano Lett. 2020 05 13; 20(5):3852-3857.
PMID: 32208712

Tracking Longitudinal Rotation of Silicon Nanowires for Biointerfaces.
Lee YV, Wu D, Fang Y, Peng Y, Tian B. Tracking Longitudinal Rotation of Silicon Nanowires for Biointerfaces. . 2020 05 13; 20(5):3852-3857.
PMID: 32208712

The guidance receptor plexin D1 is a mechanosensor in endothelial cells.
Mehta V, Pang KL, Rozbesky D, Nather K, Keen A, Lachowski D, Kong Y, Karia D, Ameismeier M, Huang J, Fang Y, Del Rio Hernandez A, Reader JS, Jones EY, Tzima E. The guidance receptor plexin D1 is a mechanosensor in endothelial cells. Nature. 2020 02; 578(7794):290-295.
PMID: 32025034

T-Cell Mechanobiology: Force Sensation, Potentiation, and Translation.
Harrison DL, Fang Y, Huang J. T-Cell Mechanobiology: Force Sensation, Potentiation, and Translation. Front Phys. 2019 Apr; 7.
PMID: 32601597

Mechanosensing and Mechanoregulation of Endothelial Cell Functions.
Fang Y, Wu D, Birukov KG. Mechanosensing and Mechanoregulation of Endothelial Cell Functions. Compr Physiol. 2019 03 15; 9(2):873-904.
PMID: 30873580

Genetic variant at coronary artery disease and ischemic stroke locus 1p32.2 regulates endothelial responses to hemodynamics.
Krause MD, Huang RT, Wu D, Shentu TP, Harrison DL, Whalen MB, Stolze LK, Di Rienzo A, Moskowitz IP, Civelek M, Romanoski CE, Fang Y. Genetic variant at coronary artery disease and ischemic stroke locus 1p32.2 regulates endothelial responses to hemodynamics. Proc Natl Acad Sci U S A. 2018 11 27; 115(48):E11349-E11358.
PMID: 30429326

Abnormalities of vascular histology and collagen fiber configuration in patients with advanced chronic kidney disease.
Allon M, Litovsky SH, Tey JCS, Sundberg CA, Zhang Y, Chen Z, Fang Y, Cheung AK, Shiu YT. Abnormalities of vascular histology and collagen fiber configuration in patients with advanced chronic kidney disease. J Vasc Access. 2019 Jan; 20(1):31-40.
PMID: 29742957

Endoplasmic Reticulum Protein TXNDC5 Augments Myocardial Fibrosis by Facilitating Extracellular Matrix Protein Folding and Redox-Sensitive Cardiac Fibroblast Activation.
Shih YC, Chen CL, Zhang Y, Mellor RL, Kanter EM, Fang Y, Wang HC, Hung CT, Nong JY, Chen HJ, Lee TH, Tseng YS, Chen CN, Wu CC, Lin SL, Yamada KA, Nerbonne JM, Yang KC. Endoplasmic Reticulum Protein TXNDC5 Augments Myocardial Fibrosis by Facilitating Extracellular Matrix Protein Folding and Redox-Sensitive Cardiac Fibroblast Activation. Circ Res. 2018 04 13; 122(8):1052-1068.
PMID: 29535165

View All Publications

B. Lowell Langille Vascular Biology Lectureship
University of Toronto
2020

Young Investigator Award (First Place)
CAAC-ATVB Symposium
2019

Leif B. Sorensen Faculty Research Award
University of Chicago
2018