Our Faculty

Yun Fang, PhD

My research foci are mechano-transduction mechanisms by which cells sense and convert environmental mechanical stimuli into biological signaling and novel nanomedicine approaches that target dysregulated mechano-sensing pathways. Cellular mechanotransduction is instrumental to embryogenesis and physiological control of tissue homeostasis; abnormal cell responses to mechanical forces promote pathologies associated with numerous human diseases. This is especially important in the vasculature, where environmental mechanical stimuli produce cellular responses in endothelial cells at arterial curvatures and bifurcations by locally disturbed blood flow to induce atherosclerosis. A similar cascade appears to be induced in acute lung injury where it is the increased cyclic stretch that is the trigger. My research program at the University of Chicago focuses on the molecular understanding of endothelial homeostasis governed by mechanical forces, with emphasis upon regulation of non-coding genome, transcription factors, G protein signaling, and genetic variance. Another major research goal is to develop innovative nanomedicine-based therapeutic strategies to treat dysregulated mechano-sensing mechanisms causing vascular diseases.



Key Words: microRNA, non-coding RNA, human genetics, enhancer biology, vascular biology, nanotechnology, nanomedicine, mechanotransduction, atherosclerosis, acute lung injury

University of Pennsylvania
USA
Postdoctoral Fellow - Medicine and Engineering
2012

University of Pennsylvania
USA
PhD - Bioengineering
2006

University of Pennsylvania
USA
MS - Biotechnology
2002

National Taiwan University
Taiwan
BS - Microbiology & Plant Pathology
1999

Targeted polyelectrolyte complex micelles treat vascular complications in vivo.
Zhou Z, Yeh CF, Mellas M, Oh MJ, Zhu J, Li J, Huang RT, Harrison DL, Shentu TP, Wu D, Lueckheide M, Carver L, Chung EJ, Leon L, Yang KC, Tirrell MV, Fang Y. Targeted polyelectrolyte complex micelles treat vascular complications in vivo. Proc Natl Acad Sci U S A. 2021 12 14; 118(50).
PMID: 34880134

Mechanical forces and metabolic changes cooperate to drive cellular memory and endothelial phenotypes.
Li J, Fang Y, Wu D. Mechanical forces and metabolic changes cooperate to drive cellular memory and endothelial phenotypes. Curr Top Membr. 2021; 87:199-253.
PMID: 34696886

Single-cell lactate production rate as a measure of glycolysis in endothelial cells.
Harrison D, Wu D, Huang J, Fang Y. Single-cell lactate production rate as a measure of glycolysis in endothelial cells. STAR Protoc. 2021 09 17; 2(3):100807.
PMID: 34527962

SARS-CoV-2 Infection Is Associated with Reduced Krüppel-like Factor 2 in Human Lung Autopsy.
Wu D, Lee TH, Huang RT, D Guzy R, Schoettler N, Adegunsoye A, Mueller J, Husain A, I Sperling A, Mutlu GM, Fang Y. SARS-CoV-2 Infection Is Associated with Reduced Krüppel-like Factor 2 in Human Lung Autopsy. Am J Respir Cell Mol Biol. 2021 08; 65(2):222-226.
PMID: 33971111

Intermittent Hypoxia-Induced Activation of Endothelial Cells Is Mediated via Sympathetic Activation-Dependent Catecholamine Release.
Cetin-Atalay R, Meliton AY, Wu D, Woods PS, Sun KA, Peng YJ, Nanduri J, Su X, Fang Y, Hamanaka RB, Prabhakar N, Mutlu GM. Intermittent Hypoxia-Induced Activation of Endothelial Cells Is Mediated via Sympathetic Activation-Dependent Catecholamine Release. Front Physiol. 2021; 12:701995.
PMID: 34322038

Endothelial Aryl Hydrocarbon Receptor Nuclear Translocator Mediates the Angiogenic Response to Peripheral Ischemia in Mice With Type 2 Diabetes Mellitus.
Nguyen T, Zheng M, Knapp M, Sladojevic N, Zhang Q, Ai L, Harrison D, Chen A, Sitikov A, Shen L, Gonzalez FJ, Zhao Q, Fang Y, Liao JJK, Wu R. Endothelial Aryl Hydrocarbon Receptor Nuclear Translocator Mediates the Angiogenic Response to Peripheral Ischemia in Mice With Type 2 Diabetes Mellitus. Front Cell Dev Biol. 2021; 9:691801.
PMID: 34179020

Single-cell metabolic imaging reveals a SLC2A3-dependent glycolytic burst in motile endothelial cells.
Wu D, Harrison DL, Szasz T, Yeh CF, Shentu TP, Meliton A, Huang RT, Zhou Z, Mutlu GM, Huang J, Fang Y. Single-cell metabolic imaging reveals a SLC2A3-dependent glycolytic burst in motile endothelial cells. Nat Metab. 2021 05; 3(5):714-727.
PMID: 34031595

Preface.
Fang Y. Preface. Curr Top Membr. 2021; 87:xiii-xv.
PMID: 34696891

Tracking Longitudinal Rotation of Silicon Nanowires for Biointerfaces.
Lee YV, Wu D, Fang Y, Peng Y, Tian B. Tracking Longitudinal Rotation of Silicon Nanowires for Biointerfaces. Nano Lett. 2020 05 13; 20(5):3852-3857.
PMID: 32208712

Tracking Longitudinal Rotation of Silicon Nanowires for Biointerfaces.
Lee YV, Wu D, Fang Y, Peng Y, Tian B. Tracking Longitudinal Rotation of Silicon Nanowires for Biointerfaces. . 2020 05 13; 20(5):3852-3857.
PMID: 32208712

View All Publications

NHLBI R35 award
National Institutes of Health
2022

B. Lowell Langille Vascular Biology Lectureship
University of Toronto
2020

Young Investigator Award (First Place)
CAAC-ATVB Symposium
2019

Leif B. Sorensen Faculty Research Award
University of Chicago
2018