Our Faculty

David Pincus, PhD

David Pincus is an Assistant Professor in the Dept. of Molecular Genetics and Cell Biology. The Pincus lab is located in the Center for Physics of Evolving Systems on the 5th floor of GCIS.



The Pincus Lab studies cellular adaptation at three levels: cell biological mechanisms of adaptation to environmental stress, global principles of adaptation and resource allocation in complex environments, and the intersection of physiological stress response factors and evolutionary adaptation.



David is trained in approaches in biochemistry, biophysics, genetics, genomics, and molecular, cell, computational, systems and synthetic biology. The lab uses budding yeast and cultured human cells as experimental models.



Key project areas:

1) Quantitative cell biology of the heat shock response

2) Single-cell transcriptomics in complex stress environments

Whitehead Institute
Cambridge, MA

2018

UCSF
San Francisco, CA
PhD - Biochemistry
2012

UC Berkeley
Berkeley, CA
BA - Molecular & Cell Biology
2004

Transcriptional regulation of Sis1 promotes fitness but not feedback in the heat shock response.
Transcriptional regulation of Sis1 promotes fitness but not feedback in the heat shock response. Elife. 2023 05 09; 12.
PMID: 37158601

Inducible transcriptional condensates drive 3D genome reorganization in the heat shock response.
Inducible transcriptional condensates drive 3D genome reorganization in the heat shock response. Mol Cell. 2022 Nov 17; 82(22):4386-4399.e7.
PMID: 36327976

Primordial super-enhancers: heat shock-induced chromatin organization in yeast.
Primordial super-enhancers: heat shock-induced chromatin organization in yeast. Trends Cell Biol. 2021 10; 31(10):801-813.
PMID: 34001402

Subcellular localization of the J-protein Sis1 regulates the heat shock response.
Subcellular localization of the J-protein Sis1 regulates the heat shock response. J Cell Biol. 2021 01 04; 220(1).
PMID: 33326013

Persistent Activation of mRNA Translation by Transient Hsp90 Inhibition.
Persistent Activation of mRNA Translation by Transient Hsp90 Inhibition. Cell Rep. 2020 Sep 08; 32(10):108149.
PMID: 32905780

Persistent Activation of mRNA Translation by Transient Hsp90 Inhibition.
Persistent Activation of mRNA Translation by Transient Hsp90 Inhibition. Cell Rep. 2020 08 11; 32(6):108001.
PMID: 32783929

Multi-kinase control of environmental stress responsive transcription.
Multi-kinase control of environmental stress responsive transcription. PLoS One. 2020; 15(3):e0230246.
PMID: 32160258

Regulation of Hsf1 and the Heat Shock Response.
Regulation of Hsf1 and the Heat Shock Response. Adv Exp Med Biol. 2020; 1243:41-50.
PMID: 32297210

Strategies for Engineering and Rewiring Kinase Regulation.
Strategies for Engineering and Rewiring Kinase Regulation. Trends Biochem Sci. 2020 03; 45(3):259-271.
PMID: 31866305

m6A modification of a 3' UTR site reduces RME1 mRNA levels to promote meiosis.
m6A modification of a 3' UTR site reduces RME1 mRNA levels to promote meiosis. Nat Commun. 2019 07 30; 10(1):3414.
PMID: 31363087

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Stewart Trust Cancer Fellowship
Alexander and Margaret Stewart Trust
2013 - 2015

Early Independence Award (DP5)
NIH Office of the Director
2013 - 2018

Graduate Research Fellowship
NSF
2007 - 2010