Dr. Mutlu is Professor of Medicine and Chief of the Section of Pulmonary and Critical Care Medicine at the University of Chicago. He is also the principal investigator/director of the NIH T32 Research training in respiratory biology. Dr. Mutlu's research focuses on the mechanisms of acute lung injury, and pulmonary fibrosis. Specifically, his laboratory is interested in understanding the role of macrophage and fibroblast metabolism including mitochondria in the pathogenesis of acute lung injury and pulmonary fibrosis. Dr. Mutlu's laboratory has extensive expertise with in vitro cell based methods including bioenergetics and in vivo models of acute lung injury (influenza, LPS, bacterial pneumonia and particulate matter) and pulmonary fibrosis (bleomycin).
Geotrichum infection in an immunocompetent host with SARS-CoV-2 infection.
Geotrichum infection in an immunocompetent host with SARS-CoV-2 infection. Tuberk Toraks. 2021 Sep; 69(3):421-424.
PMID: 34581166
SARS-CoV-2 Infection Is Associated with Reduced Krüppel-like Factor 2 in Human Lung Autopsy.
SARS-CoV-2 Infection Is Associated with Reduced Krüppel-like Factor 2 in Human Lung Autopsy. Am J Respir Cell Mol Biol. 2021 08; 65(2):222-226.
PMID: 33971111
Intermittent Hypoxia-Induced Activation of Endothelial Cells Is Mediated via Sympathetic Activation-Dependent Catecholamine Release.
Intermittent Hypoxia-Induced Activation of Endothelial Cells Is Mediated via Sympathetic Activation-Dependent Catecholamine Release. Front Physiol. 2021; 12:701995.
PMID: 34322038
Single-cell metabolic imaging reveals a SLC2A3-dependent glycolytic burst in motile endothelial cells.
Single-cell metabolic imaging reveals a SLC2A3-dependent glycolytic burst in motile endothelial cells. Nat Metab. 2021 05; 3(5):714-727.
PMID: 34031595
The role of metabolic reprogramming and de novo amino acid synthesis in collagen protein production by myofibroblasts: implications for organ fibrosis and cancer.
The role of metabolic reprogramming and de novo amino acid synthesis in collagen protein production by myofibroblasts: implications for organ fibrosis and cancer. Amino Acids. 2021 Dec; 53(12):1851-1862.
PMID: 33963932
More to Explore: Further Definition of Risk Factors for COPD - Differential Gender Difference, Modest Elevation in PM2.5, and e-Cigarette Use.
More to Explore: Further Definition of Risk Factors for COPD - Differential Gender Difference, Modest Elevation in PM2.5, and e-Cigarette Use. Front Physiol. 2021; 12:669152.
PMID: 34025456
Update in Critical Care 2020.
Update in Critical Care 2020. Am J Respir Crit Care Med. 2021 05 01; 203(9):1088-1098.
PMID: 33734938
The lung microenvironment shapes a dysfunctional response of alveolar macrophages in aging.
The lung microenvironment shapes a dysfunctional response of alveolar macrophages in aging. J Clin Invest. 2021 02 15; 131(4).
PMID: 33586677
SARS-CoV-2 infection reduces Krüppel-Like Factor 2 in human lung autopsy.
SARS-CoV-2 infection reduces Krüppel-Like Factor 2 in human lung autopsy. bioRxiv. 2021 Jan 18.
PMID: 33469586
Metabolic requirements of pulmonary fibrosis: role of fibroblast metabolism.
Metabolic requirements of pulmonary fibrosis: role of fibroblast metabolism. FEBS J. 2021 11; 288(22):6331-6352.
PMID: 33393204